https://m2.mtmt.hu/ eng 2026-05-26 00:03 JournalArticle 30317318 VALIDATED true 0 false 2026-05-25T07:19:38.470+0000 2026-05-21T05:40:57.535+0000 2018-11-13T07:15:13.797+0000 true 10037665 Bilicsi Erika /api/admin/10037665 Admin true 10037665 2026-05-21T05:40:57.884+0000 2026-05-21T05:40:57.884+0000 2024-08-21T12:57:24.369+0000 true 10075667 Szabó Emese /api/admin/10075667 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Ujfalussy, B.B. Global and Multiplexed Dendritic Computations under In Vivo-like Conditions true true /api/journal/3357 REVIEWED true false 3357 false 3357 true 0896-6273 1097-4199 Journal FOREIGN 100 3 579 592 579 14 2018 Dendrites integrate inputs nonlinearly, but it is unclear how these nonlinearities contribute to the overall input-output transformation of single neurons. We developed statistically principled methods using a hierarchical cascade of linear-nonlinear subunits (hLN) to model the dynamically evolving somatic response of neurons receiving complex, in vivo-like spatiotemporal synaptic input patterns. We used the hLN to predict the somatic membrane potential of an in vivo-validated detailed biophysical model of a L2/3 pyramidal cell. Linear input integration with a single global dendritic nonlinearity achieved above 90% prediction accuracy. A novel hLN motif, input multiplexing into parallel processing channels, could improve predictions as much as conventionally used additional layers of local nonlinearities. We obtained similar results in two other cell types. This approach provides a data-driven characterization of a key component of cortical circuit computations: the input-output transformation of neurons during in vivo-like conditions. The input-output transformation of neurons under in vivo conditions is unknown. Ujfalussy et al. use a model-based approach to show that linear integration with a single global dendritic nonlinearity can accurately predict the response of neurons to naturalistic synaptic input patterns. © 2018 The Authors Funding 1973074 /api/funding/1973074 false true Funding 1973075 /api/funding/1973075 false true Funding 1973076 /api/funding/1973076 false true Funding 1973077 /api/funding/1973077 false true Funding 1973078 /api/funding/1973078 false true true true 2018 true true true false true false GOLD 2026-05-25 true https://doi.org/10.1016/j.neuron.2018.08.032 74 0 74 71 3 71 72 69 72 74 74 71 71 71 3 0 74 71 74 71 0 7 7 Folyóiratcikk Journal Article 24 67 Könyvrészlet Chapter in Book 25 5 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 2 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2019 0 9 9 9 9 2020 0 7 6 7 6 2021 0 10 10 10 10 2022 0 18 18 18 18 2023 0 8 7 8 7 2024 0 13 12 13 12 2025 0 6 6 6 6 2026 0 3 3 3 3 D1 false 10017153 false false false 2018-11-12T07:21:11.177+0000 2018-11-13T07:21:06.395+0000 Elméleti idegtudomány és komplex rendszerek kut... (RMI / KTO); Lendület Idegi Jelátvitel Kutatócsoport (KOKI / CHO) 2 23 2 4 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 84278684 /api/authorship/84278684 1 0.25 true false true Author 10017153 /api/author/10017153 Ujfalussy Balázs Benedek true 10017153 true Ujfalussy B.B. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 84278685 /api/authorship/84278685 2 0.25 false false Author 146 /api/author/146 Makara Judit true 146 true Makara J.K. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 84278686 /api/authorship/84278686 3 0.25 false false Lengyel M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 84278687 /api/authorship/84278687 4 0.25 false true Branco T. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 14609429 /api/publicationidentifier/14609429 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Keyword 1502797 /api/keyword/1502797 true true Keyword 1502798 /api/keyword/1502798 true true SjrRating 10862642 /api/sjrrating/10862642 4 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2801 /api/classificationexternal/2801 true 2801 true D1 DIRECT true true /api/publication/30317318 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10017153"><a href="/gui2/?type=authors&mode=browse&sel=10017153" target="_blank">Ujfalussy B.B. ✉ (<span class="authorship-author-name">Ujfalussy Balázs Benedek</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Neuronal Signaling; <span title="MTA Wigner Research Centre for Physics">MTA Wigner FK</span>/<span title="Institute for Particle and Nuclear Physics">RMI</span>/<span title="Komputációs Tudományok Osztálya">KTO</span>/Theoretical neoroscience and complex system research group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="146"><a href="/gui2/?type=authors&mode=browse&sel=146" target="_blank">Makara J.K. (<span class="authorship-author-name">Makara Judit</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Neuronal Signaling</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lengyel M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Branco T. </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30317318" target="_blank">Global and Multiplexed Dendritic Computations under In Vivo-like Conditions</a></div> <div> <span class="journal-title">NEURON</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0896-6273">0896-6273</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1097-4199">1097-4199</a>)</span>: <span class="journal-volume">100</span> <span class="journal-issue">3</span> <span class="page"> pp 579-592 </span> <span class="year">(2018)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1016/j.neuron.2018.08.032" target="_blank" href="https://doi.org/10.1016/j.neuron.2018.08.032"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000449564600012" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000449564600012"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85055908808" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85055908808"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="30408443" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30408443&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="1908215544906120277" target="_blank" href="http://scholar.Google.com/scholar?hl=en&lr=&cluster=1908215544906120277"> Google scholar </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 74</span> | Independent citation: 71 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 69 | Number of citations in Scopus:&nbsp;72 | WoS/Scopus assigned:&nbsp;74 | Number of citations with DOI:&nbsp;72 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;30317318&sort=publishedYear,desc&sort=title"> Number of cited publications: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 30317318</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus (scopus (10).ris, 2018-11-13)</span> </div> <div class="funder"> Wellcome Trust International Senior Research Fellowship(090915/Z/09/Z), International Research Scholar Program of the Howard Hughes Medical Institute(55008740), Wellcome Trust/Royal Society Henry Dale Fellowship(098400/Z/12/Z), Medical Research Council (MRC)(MC-UP-1201/1), Wellcome Trust New Investigator Award(095621/Z/11/Z) </div> <div class="lastModified">Last Modified: 2026.05.21. 07:40 Adrienn Tomcsik (Wigner admin5) </div> </div></div>