https://m2.mtmt.hu/ hun 2026-03-07 19:04 JournalArticle 30309775 VALIDATED true 0 false 2025-12-27T16:13:30.121+0000 2025-05-09T15:50:53.039+0000 2018-11-06T13:13:18.353+0000 true 10037665 Bilicsi Erika /api/admin/10037665 Admin true 10037665 2026-02-20T11:07:10.435+0000 2026-02-20T11:07:10.435+0000 2025-05-09T15:50:53.044+0000 true 10067876 Ladányi Gusztáv /api/admin/10067876 Admin true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2025-05-09T15:50:52.537+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Ferrarese, L. Dendrite-Specific Amplification of Weak Synaptic Input during Network Activity In Vivo true true /api/journal/10022692 REVIEWED true false 10022692 false 10022692 true 2639-1856 2211-1247 Journal FOREIGN 24 13 3455 3465.e5 3455 2018 Excitatory synaptic input reaches the soma of a cortical excitatory pyramidal neuron via anatomically segregated apical and basal dendrites. In vivo, dendritic inputs are integrated during depolarized network activity, but how network activity affects apical and basal inputs is not understood. Using subcellular two-photon stimulation of Channelrhodopsin2-expressing layer 2/3 pyramidal neurons in somatosensory cortex, nucleus-specific thalamic optogenetic stimulation, and paired recordings, we show that slow, depolarized network activity amplifies small-amplitude synaptic inputs targeted to basal dendrites but reduces the amplitude of all inputs from apical dendrites and the cell soma. Intracellular pharmacology and mathematical modeling suggests that the amplification of weak basal inputs is mediated by postsynaptic voltage-gated channels. Thus, network activity dynamically reconfigures the relative somatic contribution of apical and basal inputs and could act to enhance the detectability of weak synaptic inputs. Ferrarese et al. investigate the impact of network activity on synaptic integration in cortical L2/3 pyramidal neurons in vivo. They report a reduction of apical dendritic inputs but an amplification of small-amplitude basal inputs during depolarized phases of slow network activity. The amplification is dependent on postsynaptic voltage-gated channels. © 2018 The Authors 2018 true true true false true false GOLD 2025-12-27 true https://doi.org/10.1016/j.celrep.2018.08.088 16 0 15 13 0 15 15 15 15 15 15 13 13 14 2 0 16 14 15 13 0 0 0 Folyóiratcikk Journal Article 24 15 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 1 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2019 0 3 2 3 2 2020 0 2 2 2 2 2021 0 3 3 3 3 2022 0 3 3 3 3 2023 0 2 1 2 1 2024 0 3 3 3 3 D1 false false false false 2018-11-05T14:42:08.998+0000 2018-11-06T14:42:08.997+0000 Információs Technológiai és Bionikai Kar (PPKE); MTA-PPKE ITK-NAP B Kétfoton méréstechnikai kuta... (PPKE / ITK); Neuronhálózat és Dendritikus Aktivitás Kutatócs... 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Balázs true 10012926 true Rózsa B. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 84237394 /api/authorship/84237394 7 0.125 false false Schreiber S. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 84237395 /api/authorship/84237395 8 0.125 false true Poulet J.F.A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 14595845 /api/publicationidentifier/14595845 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1016/j.celrep.2018.08.088 https://doi.org/10.1016/j.celrep.2018.08.088 false true PublicationIdentifier 15191300 /api/publicationidentifier/15191300 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true 000445524700010 https://www.webofscience.com/wos/woscc/full-record/000445524700010 true true PublicationIdentifier 14595844 /api/publicationidentifier/14595844 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true 85053671433 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85053671433 false true PublicationIdentifier 25767012 /api/publicationidentifier/25767012 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 30257207 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30257207&dopt=Abstract true true Keyword 56 /api/keyword/56 true 56 true Keyword 62 /api/keyword/62 true 62 true Keyword 1699 /api/keyword/1699 true 1699 true Keyword 2084 /api/keyword/2084 true 2084 true Keyword 4600 /api/keyword/4600 true 4600 true Keyword 4608 /api/keyword/4608 true 4608 true Keyword 5079 /api/keyword/5079 true 5079 true Keyword 5085 /api/keyword/5085 true 5085 true Keyword 5087 /api/keyword/5087 true 5087 true Keyword 5088 /api/keyword/5088 true 5088 true Keyword 5933 /api/keyword/5933 true 5933 true Keyword 6668 /api/keyword/6668 true 6668 true Keyword 6835 /api/keyword/6835 true 6835 true Keyword 6854 /api/keyword/6854 true 6854 true Keyword 6918 /api/keyword/6918 true 6918 true Keyword 11578 /api/keyword/11578 true 11578 true Keyword 14998 /api/keyword/14998 true 14998 true Keyword 1010083 /api/keyword/1010083 true 1010083 true Keyword 1012913 /api/keyword/1012913 true 1012913 true Keyword 1042508 /api/keyword/1042508 true 1042508 true Keyword 1210559 /api/keyword/1210559 true 1210559 true Keyword 1497508 /api/keyword/1497508 true true SjrRating 10751783 /api/sjrrating/10751783 8 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1301 /api/classificationexternal/1301 true 1301 true D1 DIRECT true true /api/publication/30309775 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" >Ferrarese L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jouhanneau J.-S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Remme M.W.H. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kremkow J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="191"><a href="/gui2/?type=authors&mode=browse&sel=191" target="_blank">Katona G. 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Balázs</span> <span class="authorAux-mtmt"> Idegtudomány, fizika</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Katolikus Egyetem">PPKE</span>/Információs Technológiai és Bionikai Kar; <span title="MTA Kísérleti Orvostudományi Kutatóintézet">MTAKOKI</span>/<span title="Gyógyszerkutatási Osztály">GYO</span>/Neuronhálózat és Dendritikus Aktivitás Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schreiber S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Poulet J.F.A. </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;30309775" target="_blank">Dendrite-Specific Amplification of Weak Synaptic Input during Network Activity In Vivo</a></div> <div> <span class="journal-title">CELL REPORTS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2639-1856">2639-1856</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2211-1247">2211-1247</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">13</span> <span class="page"> pp 3455-3465.e5 </span> <span class="year">(2018)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1016/j.celrep.2018.08.088" target="_blank" href="https://doi.org/10.1016/j.celrep.2018.08.088"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="000445524700010" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000445524700010"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="85053671433" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85053671433"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="30257207" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30257207&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 16</span> | Független: 14 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 15 | Scopus jelölt:&nbsp;15 | WoS/Scopus jelölt:&nbsp;15 | DOI jelölt:&nbsp;15 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 30309775</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus (scopus (6).ris, 2018-11-06)</span> </div> <div class="lastModified">Utolsó módosítás: 2025.05.09. 17:50 Ladányi Gusztáv (MTMT API user, admin) </div> <div class="lockedBy">Központi kezelésű 2025.05.09. 17:50 Ladányi Gusztáv (MTMT API user, admin) </div> </div></div>