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From \nthat collection two promising compounds (2 and 3) exhibiting \nhighest 5-HT2C receptor affinity strongly inhibited the 5-HT2C \nreceptor agonist 1-(3-chlorophenyl)piperazine (mCPP) induced \nhypomotility in mice. In further pursuance of that objective (2-\naminoethyl)(benzyl)sulfamoyl diphenylureas and \ndiphenylpiperazines have also been elaborated. Herein we report \nthe synthesis of potent multiple-acting compounds from this new \nclass. However, when two optimized representatives (6 and 14) \npossessing the desired in vitro profile were tested neither \nreduced the motor activity of mCPP treated animals. 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