https://m2.mtmt.hu/ eng 2026-10-25 09:00 JournalArticle 3020519 APPROVED true Magyar Tudomanyos Akademia, Department of Endocrine Neurobiology, Budapest, Hungary Semmelweis Egyetem, János Szentágothai PhD School of Neurosciences, Budapest, Hungary KU Leuven, Department of Biology, Leuven, Belgium Tufts Medical Center, Department of Medicine, Boston, United States Export Date: 11 November 2025; Cited By: 5; CODEN: ENDOA 0 2017-07-26T07:38:44.000+0000 false 3020519 2026-10-17T14:04:29.011+0000 2025-11-11T09:11:48.423+0000 2016-02-17T10:50:20.000+0000 true 10012354 Fekete Csaba /api/author/10012354 Author Csaba Fekete (Neuroendokrinológia) true 10012354 2025-11-12T08:39:47.439+0000 2025-11-12T08:39:47.439+0000 2020-12-17T11:58:42.955+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin Márta Molnár-Taga (SE 4-es admin) true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Mohacsik, P true true /api/journal/1410 REVIEWED ENDOCRINOLOGY 0013-7227 1945-7170 true false 1410 false 1410 true 0013-7227 1945-7170 Journal FOREIGN 157 3 1211 1221 1211 11 2016 The hypothalamic-pituitary-thyroid (HPT) axis is governed by hypophysiotropic thyrotropin-releasing hormone (TRH)-synthesizing neurons located in the hypothalamic paraventricular nucleus (PVN) under control of the negative feedback of thyroid hormones. The mechanisms underlying the ontogeny of this phenomenon are poorly understood. We aimed to determine the onset of thyroid hormone-mediated hypothalamic negative feedback and studied how local hypothalamic metabolism of thyroid hormones could contribute to this process in developing chicken. In situ hybridization revealed that whereas exogenous T4 did not induce a statistically significant inhibition of TRH expression in the PVN at embryonic day (E)19, T4 treatment was effective at two days after hatching (P2). In contrast, TRH expression responded to T3 treatment in both age groups. TSHbeta mRNA expression in the pituitary responded to T4 in a similar age dependent manner. Type 2 deiodinase (D2) was expressed from E13 in tanycytes of the mediobasal hypothalamus (MBH) and its activity increased between E15 to P2 both in the MBH and in tanycyte-lacking hypothalamic regions. Nkx2.1 was coexpressed with D2 in E13 and P2 tanycytes and transcription of the cdio2 gene responded to Nkx2.1 in U87 glioma cells indicating its potential role in developmental regulation of D2 activity. The T3-degrading D3 enzyme was also detected in tanycytes but its level was not markedly changed before and after the period of negative feedback acquisition. The findings suggest that increasing D2-mediated T3 generation during E18-P2 could provide the sufficient local T3 concentration required for the onset of T3-dependent negative feedback in the developing chicken hypothalamus. Funding 1993422 /api/funding/1993422 National Science Foundation of Hungary Grants OTKA(K109710) false true Funding 1993423 /api/funding/1993423 National Science Foundation of Hungary Grants OTKA(K109415) false true true true 2016 876860 true true true false true false GOLD 2026-10-17 true https://doi.org/10.1210/en.2015-1496 true 10039736 xRadó Nikolett /api/admin/10039736 Admin Nikolett xRadó (KOKI admin 4 INAKTÍV) true 10039736 6 0 6 4 0 5 6 5 6 6 6 4 4 4 2 0 6 4 6 4 0 16 16 Folyóiratcikk Journal Article 24 4 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2016 0 1 1 1 1 2017 0 1 0 1 0 2018 0 0 0 0 0 2019 0 1 1 1 1 2020 0 1 1 1 1 2021 0 1 0 1 0 2022 0 0 0 0 0 2023 0 0 0 0 0 2024 0 0 0 0 0 2025 0 1 1 1 1 Q1 true false false false 2016-05-19T06:18:38.000+0000 2016-02-19T07:18:38.000+0000 Doktori Iskola (SE); Integratív Neuroendokrinológiai Kutatócsoport (HRN KOKI); Molekuláris Sejt Metabolizmus Kutatócsoport (HRN KOKI) 6 31 3 9 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 85004303 /api/authorship/85004303 Mohacsik, P [Mohácsik, Petra (Neuroendokrinológia), author] School of Ph. 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Studies (SU); Laboratory of Molecular Cell Metabolism 1 0.111 true false Author 10023404 /api/author/10023404 Petra Mohácsik (Neuroendokrinológia) Mohácsik Petra true 10023404 true Mohacsik P true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 85004304 /api/authorship/85004304 Fuzesi, T [Füzesi, Tamás (Endokrin neurobio...), author] 2 0.11111111 false false Author 188 /api/author/188 Tamás Füzesi (Endokrin neurobiológia) Füzesi Tamás true 188 true Fuzesi T true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 7522714 /api/authorship/7522714 Doleschall, M [Doleschall, Márton (Genetika), author] 3 0.11111111 false false Author 10002979 /api/author/10002979 Márton Doleschall (Genetika) Doleschall Márton true 10002979 true Doleschall M true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 23497340 true PersonAuthorship 7522715 /api/authorship/7522715 Szilvasy-Szabó, A [Stiftné Szilvásy-Szabó, Anett (Neuroendokrinológia), author] School of Ph. 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Studies (SU); Integratív Neuroendokrinológiai Kutatócsoport 4 0.111 false false Author 10055055 /api/author/10055055 Anett Stiftné Szilvásy-Szabó (Neuroendokrinológia) Stiftné Szilvásy-Szabó Anett true 10055055 true Szilvasy-Szabó A true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 23497339 true PersonAuthorship 7522716 /api/authorship/7522716 Vancamp, P 5 0.11111111 false false Vancamp P true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 23497338 true PersonAuthorship 7522717 /api/authorship/7522717 Hadadi, E 6 0.11111111 false false Hadadi E true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 23497337 true PersonAuthorship 7522718 /api/authorship/7522718 Darras, VM 7 0.11111111 false false Darras VM true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false 23497336 true PersonAuthorship 85004305 /api/authorship/85004305 Fekete, C [Fekete, Csaba (Neuroendokrinológia), author] Integratív Neuroendokrinológiai Kutatócsoport 8 0.11111111 false false Author 10012354 /api/author/10012354 Csaba Fekete (Neuroendokrinológia) Fekete Csaba true 10012354 true Fekete C true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 85004306 /api/authorship/85004306 Gereben, B ✉ [Gereben, Balázs (Pajzsmirigy endok...), author] Laboratory of Molecular Cell Metabolism 9 0.111 false true true Author 10011473 /api/author/10011473 Balázs Gereben (Pajzsmirigy endokrinológia) Gereben Balázs true 10011473 true Gereben B true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 1070734 /api/publicationidentifier/1070734 DOI: 10.1210/en.2015-1496 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1210/en.2015-1496 https://doi.org/10.1210/en.2015-1496 false 1312444 true PublicationIdentifier 1070732 /api/publicationidentifier/1070732 WoS: 000374579000022 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000374579000022 https://www.webofscience.com/wos/woscc/full-record/000374579000022 false 1418133 true PublicationIdentifier 1070733 /api/publicationidentifier/1070733 Scopus: 84960532508 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84960532508 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84960532508 false 1415262 true PublicationIdentifier 1070735 /api/publicationidentifier/1070735 PubMed: 26779746 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false NO 26779746 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26779746&dopt=Abstract false 1312445 true Classification 10545 /api/classification/10545 Biological sciences true true Classification 12215 /api/classification/12215 Clinical medicine true true SjrRating 10931074 /api/sjrrating/10931074 sjr:Q1 (2016) Scopus - Endocrinology ENDOCRINOLOGY 0013-7227 1945-7170 14 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1310 /api/classificationexternal/1310 Scopus - Endocrinology true 1310 true Q1 DIRECT true true Reference 2076973 /api/reference/2076973 1. 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(2016) ENDOCRINOLOGY 0013-7227 1945-7170 157 3 1211-1221<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10023404"><a href="/gui2/?type=authors&mode=browse&sel=10023404" target="_blank">Mohacsik P (<span class="authorship-author-name">Mohácsik Petra</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of Ph. D. Studies; <span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Molecular Cell Metabolism</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="188"><a href="/gui2/?type=authors&mode=browse&sel=188" target="_blank">Fuzesi T (<span class="authorship-author-name">Füzesi Tamás</span> <span class="authorAux-mtmt"> Endokrin neurobiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002979"><a href="/gui2/?type=authors&mode=browse&sel=10002979" target="_blank">Doleschall M (<span class="authorship-author-name">Doleschall Márton</span> <span class="authorAux-mtmt"> Genetika</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055055"><a href="/gui2/?type=authors&mode=browse&sel=10055055" target="_blank">Szilvasy-Szabó A (<span class="authorship-author-name">Stiftné Szilvásy-Szabó Anett</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of Ph. D. Studies; <span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Integratív Neuroendokrinológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Vancamp P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hadadi E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Darras VM </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012354"><a href="/gui2/?type=authors&mode=browse&sel=10012354" target="_blank">Fekete C (<span class="authorship-author-name">Fekete Csaba</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Integratív Neuroendokrinológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011473"><a href="/gui2/?type=authors&mode=browse&sel=10011473" target="_blank">Gereben B ✉ (<span class="authorship-author-name">Gereben Balázs</span> <span class="authorAux-mtmt"> Pajzsmirigy endokrinológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Molecular Cell Metabolism</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3020519" target="_blank">IIncreased Thyroid Hormone Activation Accompanies the Formation of Thyroid Hormone-Dependent Negative Feedback in Developing Chicken Hypothalamus</a></div> <div> <span class="journal-title">ENDOCRINOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0013-7227">0013-7227</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1945-7170">1945-7170</a>)</span>: <span class="journal-volume">157</span> <span class="journal-issue">3</span> <span class="page"> pp 1211-1221 </span> <span class="year">(2016)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1210/en.2015-1496" target="_blank" href="https://doi.org/10.1210/en.2015-1496"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000374579000022" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000374579000022"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84960532508" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84960532508"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="26779746" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26779746&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 6</span> | Independent citation: 4 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 5 | Number of citations in Scopus:&nbsp;6 | WoS/Scopus assigned:&nbsp;6 | Number of citations with DOI:&nbsp;6 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3020519&sort=publishedYear,desc&sort=title"> Number of cited publications: 16 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 3020519</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 3020519</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="funder"> National Science Foundation of Hungary Grants OTKA(K109710), National Science Foundation of Hungary Grants OTKA(K109415) </div> <div class="lastModified">Last Modified: 2025.11.11. 10:11 Márta Turek (KOKI admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Magyar Tudomanyos Akademia, Department of Endocrine Neurobiology, Budapest, Hungary Semmelweis Egyetem, János Szentágothai PhD School of Neurosciences, Budapest, Hungary KU Leuven, Department of Biology, Leuven, Belgium Tufts Medical Center, Department of Medicine, Boston, United States Export Date: ...</pre> </div></div>