https://m2.mtmt.hu/ eng 2026-10-24 17:44 JournalArticle 3011836 VALIDATED true 0 2017-03-01T12:36:28.000+0000 false 3011836 2026-10-17T13:22:57.657+0000 2025-01-02T15:11:02.223+0000 2016-02-02T09:40:55.000+0000 true 10020826 Aliczki Manó /api/author/10020826 Author true 10020826 2026-01-12T09:29:32.738+0000 2026-01-12T09:29:32.738+0000 2025-01-02T15:11:02.417+0000 true 10003132 Balázs András /api/admin/10003132 Admin true 10003132 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10003132 /api/admin/10003132 Balázs András true 10003132 true 2024-10-17T16:47:09.541+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Aliczki, M The effects anandamide signaling in the prelimbic cortex and basolateral amygdala on coping with environmental stimuli in rats true true /api/journal/3816 REVIEWED true false 3816 false 3816 true 0033-3158 1432-2072 Journal FOREIGN 233 10 1889 1899 1889 11 2016 RATIONALE: Several lines of recent evidence suggest that endocannabinoids affect behavior by influencing the general patterns of challenge responding. OBJECTIVES: Here, we investigated the brain mechanisms underlying this phenomenon in rats. METHODS: The anandamide hydrolysis inhibitor URB597 was condensed into the tip of stainless steel cannulae, which were chronically implanted slightly above the prelimbic cortex (PRL) or the basolateral amygdala (BLA), two important regions of coping and endocannabinoid action. Thereafter, we investigated behavioral responsiveness to ambient light level in the elevated plus-maze and conditioned fear tests. RESULTS: URB597 concentration was ~30 mug/mg protein in target areas; local brain anandamide levels increased threefold, without significant changes in 2-arachidonoylglycerol. High levels of illumination halved the time spent by controls in the open arms of the plus-maze. No similar decrease was observed in rats with URB597 implants in the PRL. High light decreased conditioned fear by 30 % in controls, but not in rats with prelimbic URB597 implants. Unresponsiveness to environmental challenges was not attributable to the anxiolytic effects of anandamide enhancement, as implants induced paradoxical anxiogenic-like effects under low light, which could be explained by effects on stimulus responsiveness rather than by effects on anxiety. URB597 implants targeting the BLA did not affect stimulus responsiveness. CONCLUSIONS: Our findings show that elevated prelimbic anandamide signaling leads to less environment-dependent (more autonomous) behavioral responses to challenges, which is an attribute of active coping styles. These findings are discussed in light of two emerging concepts of endocannabinoid roles, particularly "emotional homeostasis" and "active coping." true true 2016 658610 true true true false true false GREEN GREEN 2026-10-17 true https://real.mtak.hu/35165 true 10039736 xRadó Nikolett /api/admin/10039736 Admin true 10039736 10 0 10 10 1 10 10 9 9 10 10 10 10 10 0 0 10 10 10 10 0 5 5 Folyóiratcikk Journal Article 24 9 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2016 0 1 1 1 1 2017 0 1 1 1 1 2018 0 3 3 3 3 2019 0 1 1 1 1 2020 0 1 1 1 1 2021 0 1 1 1 1 2022 0 0 0 0 0 2023 0 0 0 0 0 2024 0 1 1 1 1 2025 0 1 1 1 1 Q1 false false false false 2017-03-01T12:36:28.000+0000 2016-05-04T11:23:39.000+0000 Magatartásélettan és Stressz Kutatócsoport (KOKI / MO); Molekuláris Farmakológia Kutatócsoport (KOKI / GYO) 5 29 2 7 0 true 10003132 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 7447426 /api/authorship/7447426 1 0.14285715 true false Author 10020826 /api/author/10020826 Aliczki Manó true 10020826 true Aliczki M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 23447834 true PersonAuthorship 7447427 /api/authorship/7447427 2 0.143 true false Author 58 /api/author/58 Barna István true 58 true Barna I true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 23447833 true PersonAuthorship 7447428 /api/authorship/7447428 3 0.14285715 false false Till I true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 23447832 true PersonAuthorship 7447429 /api/authorship/7447429 4 0.14285715 false false Author 91 /api/author/91 Baranyi Mária true 91 true Baranyi M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 23447831 true PersonAuthorship 7447430 /api/authorship/7447430 5 0.143 false false Author 10008942 /api/author/10008942 Sperlágh Beáta true 10008942 true Sperlagh B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 23447830 true PersonAuthorship 7447431 /api/authorship/7447431 6 0.14285715 false false Goldberg SR true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 23447829 true PersonAuthorship 7447432 /api/authorship/7447432 7 0.143 false true true Author 10011498 /api/author/10011498 Haller József true 10011498 true Haller J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 23447828 true PublicationIdentifier 1064649 /api/publicationidentifier/1064649 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1007/s00213-016-4219-8 https://doi.org/10.1007/s00213-016-4219-8 false 1301097 true PublicationIdentifier 1064651 /api/publicationidentifier/1064651 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GREEN true NO 35165 https://real.mtak.hu/35165 false 1357396 true PublicationIdentifier 1064647 /api/publicationidentifier/1064647 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000374977400013 https://www.webofscience.com/wos/woscc/full-record/000374977400013 false 1555170 true PublicationIdentifier 1064648 /api/publicationidentifier/1064648 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84955244448 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84955244448 false 1402519 true PublicationIdentifier 1064650 /api/publicationidentifier/1064650 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false NO 26809457 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26809457&dopt=Abstract false 1301098 true Classification 12125 /api/classification/12125 true true Classification 12215 /api/classification/12215 true true SjrRating 10955213 /api/sjrrating/10955213 43 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3004 /api/classificationexternal/3004 true 3004 true Q1 DIRECT true true /api/publication/3011836 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10020826"><a href="/gui2/?type=authors&mode=browse&sel=10020826" target="_blank">Aliczki M (<span class="authorship-author-name">Aliczki Manó</span> <span class="authorAux-mtmt"> Magatartásélettan</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Deparment of Behavioural Neurobiology">DBN</span>/Laboratory of Behavioural and Stress Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="58"><a href="/gui2/?type=authors&mode=browse&sel=58" target="_blank">Barna I<sup>*</sup> (<span class="authorship-author-name">Barna István</span> <span class="authorAux-mtmt"> Magatartásélettan</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Deparment of Behavioural Neurobiology">DBN</span>/Laboratory of Behavioural and Stress Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Till I </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="91"><a href="/gui2/?type=authors&mode=browse&sel=91" target="_blank">Baranyi M (<span class="authorship-author-name">Baranyi Mária</span> <span class="authorAux-mtmt"> Molekuláris farmakológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Molecular Pharmacology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008942"><a href="/gui2/?type=authors&mode=browse&sel=10008942" target="_blank">Sperlagh B (<span class="authorship-author-name">Sperlágh Beáta</span> <span class="authorAux-mtmt"> Neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Molecular Pharmacology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Goldberg SR </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011498"><a href="/gui2/?type=authors&mode=browse&sel=10011498" target="_blank">Haller J ✉ (<span class="authorship-author-name">Haller József</span> <span class="authorAux-mtmt"> Magatartás neurobiológiája, Kriminálpszichológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Deparment of Behavioural Neurobiology">DBN</span>/Laboratory of Behavioural and Stress Studies</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3011836" target="_blank">The effects anandamide signaling in the prelimbic cortex and basolateral amygdala on coping with environmental stimuli in rats</a></div> <div> <span class="journal-title">PSYCHOPHARMACOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0033-3158">0033-3158</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1432-2072">1432-2072</a>)</span>: <span class="journal-volume">233</span> <span class="journal-issue">10</span> <span class="page"> pp 1889-1899 </span> <span class="year">(2016)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s00213-016-4219-8" target="_blank" href="https://doi.org/10.1007/s00213-016-4219-8"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="35165" target="_blank" href="https://real.mtak.hu/35165"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000374977400013" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000374977400013"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84955244448" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84955244448"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="26809457" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26809457&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 10</span> | Independent citation: 10 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 9 | Number of citations in Scopus:&nbsp;9 | WoS/Scopus assigned:&nbsp;10 | Number of citations with DOI:&nbsp;10 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3011836&sort=publishedYear,desc&sort=title"> Number of cited publications: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 3011836</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 3011836</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2025.01.02. 16:11 András Balázs (MTMT Központ, admin) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:47 Gusztáv Ladányi (MTMT API user, admin) András Balázs (MTMT Központ, admin) </div> </div></div>