Shmuel Cabilly presents in Combinatorial Peptide Library Protocols a collection of
new and unique techniques for the construction and use of peptide libraries. These
powerful methods-often detailed here by their pioneers-include protocols for the chemical
synthesis of peptide libraries, for constructing peptide libraries that are displayed
on the surface of filamentous phage or bacteria, and for the rapid screening of these
libraries for molecules with biospecific properties. Additional methods permit identifying
specific enzyme substrates, investigating the recognition spectra of various binding
proteins, epitope mapping, and identifying mimotopes.
Combinatorial Peptide Library Protocols offers novice and experienced investigators
alike the ability to select molecules from a randomized pool having specific biological
activities. Its state-of-the-art techniques, combined with clear step-by-step instructions,
make this book an essential tool in the selection of peptides suitable for drug development.
