https://m2.mtmt.hu/ hun 2026-06-24 03:11 JournalArticle 3004710 VALIDATED true 0 2017-07-31T21:04:35.000+0000 false 3004710 2026-06-22T08:42:44.467+0000 2025-05-21T06:22:03.249+0000 2016-01-23T13:57:18.000+0000 true 146 Makara Judit /api/author/146 Author true 146 2025-04-10T09:31:45.329+0000 2025-04-10T09:31:45.329+0000 2025-05-21T06:22:03.675+0000 true 10079265 Tomcsik Adrienn /api/admin/10079265 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Ujfalussy, BB Dendritic nonlinearities are tuned for efficient spike-based computations in cortical circuits. true true /api/journal/10031024 REVIEWED true false 10031024 false 10031024 true 2050-084X Journal FOREIGN 4 e10056 e10056 51 2015 Cortical neurons integrate thousands of synaptic inputs in their dendrites in highly nonlinear ways. It is unknown how these dendritic nonlinearities in individual cells contribute to computations at the level of neural circuits. Here we show that dendritic nonlinearities are critical for the efficient integration of synaptic inputs in circuits performing analog computations with spiking neurons. We developed a theory that formalises how a neuron's dendritic nonlinearity that is optimal for integrating synaptic inputs depends on the statistics of its presynaptic activity patterns. Based on their in vivo preynaptic population statistics (firing rates, membrane potential fluctuations, and correlations due to ensemble dynamics), our theory accurately predicted the responses of two different types of cortical pyramidal cells to patterned stimulation by two-photon glutamate uncaging. These results reveal a new computational principle underlying dendritic integration in cortical neurons by suggesting a functional link between cellular and systems-level properties of cortical circuits. Funding 1965938 /api/funding/1965938 false 1965938 true true true 2016 803172 true true true false true false GOLD 2026-06-22 true https://doi.org/10.7554/eLife.10056 true 10039656 Kmety Andrea /api/admin/10039656 Admin true 10039656 33 0 32 26 4 32 32 28 32 32 32 26 26 27 6 0 33 27 32 26 0 20 20 Folyóiratcikk Journal Article 24 30 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 1 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2016 0 1 0 1 0 2017 0 2 2 2 2 2018 0 5 3 5 3 2019 0 3 2 3 2 2020 0 5 4 5 4 2021 0 6 6 6 6 2022 0 3 2 3 2 2023 0 2 2 2 2 2024 0 3 3 3 3 2025 0 2 2 2 2 2026 0 1 1 1 1 D1 true 10017153 false false false 2017-02-25T11:47:11.000+0000 2016-01-23T13:59:37.000+0000 Elméleti idegtudomány és komplex rendszerek kut... (RMI / KTO); Lendület Idegi Jelátvitel Kutatócsoport (KOKI / CHO) 2 23 2 4 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 7322042 /api/authorship/7322042 1 0.25 true false true Author 10017153 /api/author/10017153 Ujfalussy Balázs Benedek true 10017153 true Ujfalussy BB true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 23336074 true PersonAuthorship 7322043 /api/authorship/7322043 2 0.25 false false Author 146 /api/author/146 Makara Judit true 146 true Makara JK true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 23336073 true PersonAuthorship 7322044 /api/authorship/7322044 3 0.25 false false Branco T true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 23336072 true PersonAuthorship 7322045 /api/authorship/7322045 4 0.25 false true Lengyel M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 23336071 true PublicationIdentifier 1059118 /api/publicationidentifier/1059118 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.7554/eLife.10056 https://doi.org/10.7554/eLife.10056 false 1292275 true PublicationIdentifier 16819256 /api/publicationidentifier/16819256 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 000373816100001 https://www.webofscience.com/wos/woscc/full-record/000373816100001 true true PublicationIdentifier 1059117 /api/publicationidentifier/1059117 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84988674598 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84988674598 false 1695366 true PublicationIdentifier 1059120 /api/publicationidentifier/1059120 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 26705334 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26705334&dopt=Abstract false 1292276 true PublicationIdentifier 1059119 /api/publicationidentifier/1059119 PlainSource 12 /api/publicationsource/12 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Google scholar http://scholar.Google.com/scholar?hl=en&lr=&cluster=@@@ true true 12 true false IDENTICAL 8381172103739485941 http://scholar.Google.com/scholar?hl=en&lr=&cluster=8381172103739485941 false 1695365 true Classification 12125 /api/classification/12125 true true Classification 10545 /api/classification/10545 true true Classification 12548 /api/classification/12548 true true Classification 12215 /api/classification/12215 true true SjrRating 11037566 /api/sjrrating/11037566 20 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true D1 DIRECT true true /api/publication/3004710 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10017153"><a href="/gui2/?type=authors&mode=browse&sel=10017153" target="_blank">Ujfalussy BB ✉ (<span class="authorship-author-name">Ujfalussy Balázs Benedek</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">MTAKOKI</span>/<span title="Celluláris és Hálózat-neurobiológiai Osztály">CHO</span>/Lendület Idegi Jelátvitel Kutatócsoport; <span title="MTA Wigner Fizikai Kutatóközpont">MTA Wigner</span>/<span title="Részecske- és Magfizikai Intézet">RMI</span>/<span title="Elméleti Fizikai Osztály">ELMO</span>/Elméleti idegtudomány és komplex rendszerek kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="146"><a href="/gui2/?type=authors&mode=browse&sel=146" target="_blank">Makara JK (<span class="authorship-author-name">Makara Judit</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">MTAKOKI</span>/<span title="Celluláris és Hálózat-neurobiológiai Osztály">CHO</span>/Lendület Idegi Jelátvitel Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Branco T </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lengyel M </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3004710" target="_blank">Dendritic nonlinearities are tuned for efficient spike-based computations in cortical circuits.</a></div> <div> <span class="journal-title">ELIFE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2050-084X">2050-084X</a>)</span>: <span class="journal-volume">4</span> <span class="page"> Paper e10056. 51 p. </span> <span class="year">(2015)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.7554/eLife.10056" target="_blank" href="https://doi.org/10.7554/eLife.10056"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000373816100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000373816100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84988674598" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84988674598"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="26705334" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26705334&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="8381172103739485941" target="_blank" href="http://scholar.Google.com/scholar?hl=en&lr=&cluster=8381172103739485941"> Google scholar </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology and Microbiology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 33</span> | Független: 27 | Függő: 6 | Nem jelölt: 0 | WoS jelölt: 28 | Scopus jelölt:&nbsp;32 | WoS/Scopus jelölt:&nbsp;32 | DOI jelölt:&nbsp;32 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3004710&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 20 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3004710</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 3004710</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="funder"> Támogató: MTA Lendület </div> <div class="lastModified">Utolsó módosítás: 2025.05.21. 08:22 Tomcsik Adrienn (Wigner admin5) </div> </div></div>