The deeper understanding of protein structure now emerging from cutting-edge research
is not only illuminating evolutionary and biochemical mechanisms, but also promises
enormous ramifications for molecular medicine, as well as for biotechnology, biophysics,
biology, genetics, and other molecular sciences. In Protein Structure Prediction:
Methods and Protocols, world-class investigators detail their most successful methods-and
the theory behind them-for delineating the shape, form, and function of proteins.
The protocols range from basic to advanced and include sequence alignment, the prediction
of transmembrane protein structure, and the development of suitable folding potentials.
There are also techniques for receptor site prediction, the identification of motifs
and domains, the comparative modeling of proteins, the docking of peptides and ligands,
and ab initio approaches to protein loop and side-chain prediction. To ensure robust
and successful experimental results, each protocol contains step-by-step instructions,
as well as tips on pitfalls to avoid and how procedures may be optimized for different
systems.
Comprehensive, accessible, and highly practical, Protein Structure Prediction: Methods
and Protocols offers protein researchers, structural biologists, and other investigators
a critical synthesis of the latest research results, as well as the vital guidance
needed to understand the structure and interaction of proteins and peptides.
