https://m2.mtmt.hu/ eng 2026-08-24 10:25 JournalArticle 2990683 VALIDATED true 0 2018-10-02T08:54:25.000+0000 false 2990683 2026-07-17T01:00:31.106+0000 2020-12-05T15:21:20.566+0000 2016-01-05T07:51:16.000+0000 true 10028817 Csontné Kiricsi Mónika /api/author/10028817 Author true 10028817 2025-08-21T08:27:00.236+0000 2025-08-21T08:27:00.236+0000 2017-01-09T15:31:07.000+0000 true 10017714 Vándor Andrea /api/admin/10017714 Admin true 10017714 2020-04-22T13:45:29.821+0000 true 10068469 Márton Réka /api/admin/10068469 Admin true Admin 10097588 /api/admin/10097588 Szatmári Erika true true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2024-10-17T16:36:32.894+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kovács, Dávid Silver nanoparticles modulate ABC transporter activity and enhance chemotherapy in multidrug resistant cancer true true /api/journal/10011738 REVIEWED true false 10011738 false 10011738 true 1549-9634 1549-9642 Journal FOREIGN 12 3 601 610 601 10 2016 Abstract The emergence of multidrug resistant (MDR) cancer phenotypes dramatically attenuates the efficiency of antineoplastic drug treatments often leading to the failure of chemotherapy. Therefore there is an urgent need to engineer new therapeutically useful agents and propose innovative approaches able to defeat resistant cancer cells. Although the remarkable anti-cancer features of silver nanoparticles (AgNPs) have already been delineated their impact on MDR cancer has never been investigated. Herein, we report that AgNPs have a notable anti-proliferative effect and induce apoptosis mediated cell death both in drug sensitive and in MDR cancer cells. Furthermore we show evidence that AgNPs exert an inhibitory action on the efflux activity of MDR cancer cells which feature could be exploited to enhance drug accumulation. We verified synergistic interactions of AgNPs with six different antineoplastic agents on drug resistant cells which emphasizes the excellent potential of AgNPs as combinational partners in the chemotherapy of MDR cancer. 2016 (Kónya Zoltán (Nanotechnológia); 2016.01.05. 08:50:35) true true true false true false RESTRICTED 2026-07-17 false true 10029205 Kresák Réka /api/admin/10029205 Admin true 10029205 81 0 81 74 7 81 81 69 72 74 74 67 67 74 7 0 81 74 81 74 0 4 4 Folyóiratcikk Journal Article 24 73 Könyvrészlet Chapter in Book 25 8 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2016 0 2 1 2 1 2017 0 6 6 6 6 2018 0 12 11 12 11 2019 0 7 6 7 6 2020 0 5 5 5 5 2021 0 10 10 10 10 2022 0 7 5 7 5 2023 0 11 10 11 10 2024 0 9 9 9 9 2025 0 9 8 9 8 2026 0 3 3 3 3 D1 false 10023650,10005827,10028817 false false false 2017-01-09T15:31:07.000+0000 2016-01-05T07:52:07.000+0000 Alkalmazott és Környezeti Kémiai Tanszék (SZTE / TTIK / KI); Biokémiai Intézet (HRN SZBK); Biokémiai és Molekuláris Biológiai Tanszék (SZTE / TTIK / BI); MTA-SZTE Reakciókinetikai és Felületkémiai Kuta... (SZTE / TTIK / KI); Orvosi Mikrobiológiai és Immunbiológiai Intézet (SZTE / ÁOK); Pathologiai Intézet (SZTE / SZAOK) 9 45 6 11 0 true 10067876 10097588 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 6952543 /api/authorship/6952543 1 0.091 true false Author 10048382 /api/author/10048382 Kovács Dávid true 10048382 true Kovács Dávid true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22892974 true PersonAuthorship 6952544 /api/authorship/6952544 2 0.09090909 false false Szőke Krisztina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22892973 true PersonAuthorship 6952545 /api/authorship/6952545 3 0.091 false false Author 10054252 /api/author/10054252 Igaz Nóra true 10054252 true Igaz Nóra true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22892972 true PersonAuthorship 6952546 /api/authorship/6952546 4 0.09090909 false false Author 10012633 /api/author/10012633 Spengler Gabriella true 10012633 true Spengler Gabriella true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22892971 true PersonAuthorship 6952547 /api/authorship/6952547 5 0.09090909 false false Author 10005827 /api/author/10005827 Molnár József true 10005827 true Molnár József true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22892970 true PersonAuthorship 6952548 /api/authorship/6952548 6 0.09090909 false false Tóth Tímea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22892969 true PersonAuthorship 6952549 /api/authorship/6952549 7 0.091 false false Author 10037937 /api/author/10037937 Madarász Dániel true 10037937 true Madarász Dániel true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22892968 true PersonAuthorship 6952550 /api/authorship/6952550 8 0.09090909 false false Author 10023650 /api/author/10023650 Rázga Zsolt true 10023650 true Rázga Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22892967 true PersonAuthorship 6952551 /api/authorship/6952551 9 0.091 false false Author 10000005 /api/author/10000005 Kónya Zoltán true 10000005 true Kónya Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22892966 true PersonAuthorship 6952552 /api/authorship/6952552 10 0.091 false false Author 10000502 /api/author/10000502 Boros Imre Miklós true 10000502 true Boros Imre M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22892965 true PersonAuthorship 6952553 /api/authorship/6952553 11 0.091 false true true Author 10028817 /api/author/10028817 Csontné Kiricsi Mónika true 10028817 true Kiricsi Mónika true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22892964 true PublicationIdentifier 1049597 /api/publicationidentifier/1049597 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI 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http://publicatio.bibl.u-szeged.hu/7723 false 1387926 true Classification 12125 /api/classification/12125 true true Classification 11027 /api/classification/11027 true true Classification 12548 /api/classification/12548 true true Classification 10799 /api/classification/10799 true true Classification 12215 /api/classification/12215 true true Keyword 18454 /api/keyword/18454 true 18454 true Keyword 1092476 /api/keyword/1092476 true 1092476 true Keyword 1387676 /api/keyword/1387676 true 1387676 true SjrRating 10917442 /api/sjrrating/10917442 21 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2204 /api/classificationexternal/2204 true 2204 true D1 DIRECT true true /api/publication/2990683 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10048382"><a href="/gui2/?type=authors&mode=browse&sel=10048382" target="_blank">Kovács Dávid (<span class="authorship-author-name">Kovács Dávid</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Biológia Intézet">BI</span>/Department of Biochemistry and Molecular Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szőke Krisztina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054252"><a href="/gui2/?type=authors&mode=browse&sel=10054252" target="_blank">Igaz Nóra (<span class="authorship-author-name">Igaz Nóra</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Biológia Intézet">BI</span>/Department of Biochemistry and Molecular Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012633"><a href="/gui2/?type=authors&mode=browse&sel=10012633" target="_blank">Spengler Gabriella (<span class="authorship-author-name">Spengler Gabriella</span> <span class="authorAux-mtmt"> Orvosi mikrobiológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Medicine">ÁOK</span>/Department of Medical Microbiology and Immunobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10005827"><a href="/gui2/?type=authors&mode=browse&sel=10005827" target="_blank">Molnár József (<span class="authorship-author-name">Molnár József</span> <span class="authorAux-mtmt"> Mikrobiológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Medicine">ÁOK</span>/Department of Medical Microbiology and Immunobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tóth Tímea </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10037937"><a href="/gui2/?type=authors&mode=browse&sel=10037937" target="_blank">Madarász Dániel (<span class="authorship-author-name">Madarász Dániel</span> <span class="authorAux-mtmt"> kémia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Kémiai Intézet">KI</span>/Department of Applied and Environmental Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023650"><a href="/gui2/?type=authors&mode=browse&sel=10023650" target="_blank">Rázga Zsolt (<span class="authorship-author-name">Rázga Zsolt</span> <span class="authorAux-mtmt"> Farmakológia, funkcionális morfológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Medicine">ÁOK</span>/Department of Pathology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000005"><a href="/gui2/?type=authors&mode=browse&sel=10000005" target="_blank">Kónya Zoltán (<span class="authorship-author-name">Kónya Zoltán</span> <span class="authorAux-mtmt"> Nanotechnológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Kémiai Intézet">KI</span>/Department of Applied and Environmental Chemistry; <span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Kémiai Intézet">KI</span>/MTA-SZTE Reakciókinetikai és Felületkémiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000502"><a href="/gui2/?type=authors&mode=browse&sel=10000502" target="_blank">Boros Imre M (<span class="authorship-author-name">Boros Imre Miklós</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Központ">MTA SZBK</span>/Institute of Biochemistry; <span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Biológia Intézet">BI</span>/Department of Biochemistry and Molecular Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028817"><a href="/gui2/?type=authors&mode=browse&sel=10028817" target="_blank">Kiricsi Mónika ✉ (<span class="authorship-author-name">Csontné Kiricsi Mónika</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Biológia Intézet">BI</span>/Department of Biochemistry and Molecular Biology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2990683" target="_blank">Silver nanoparticles modulate ABC transporter activity and enhance chemotherapy in multidrug resistant cancer</a></div> <div> <span class="journal-title">NANOMEDICINE: NANOTECHNOLOGY BIOLOGY AND MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1549-9634">1549-9634</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1549-9642">1549-9642</a>)</span>: <span class="journal-volume">12</span> <span class="journal-issue">3</span> <span class="page"> pp 601-610 </span> <span class="year">(2016)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Pay "> <a style="color:blue" title="10.1016/j.nano.2015.10.015" target="_blank" href="https://doi.org/10.1016/j.nano.2015.10.015"> DOI </a> </span> <span class="id 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<OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biomedical Engineering&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Materials Science (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Pharmaceutical Science&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Bioengineering&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Molecular Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Nanoscience and Nanotechnology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 81</span> | Independent citation: 74 | Self citation: 7 | Unknown citation: 0 | Number of citations in WoS: 69 | Number of citations in Scopus:&nbsp;72 | WoS/Scopus assigned:&nbsp;74 | Number of citations with DOI:&nbsp;81 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2990683&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2990683</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 2990683</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="lastModified">Last Modified: 2020.12.05. 16:21 import WoS (admin) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:36 Erika Szatmári (MTMT ellenőrzés, admin) Gusztáv Ladányi (MTMT API user, admin) </div> </div></div>