https://m2.mtmt.hu/ hun 2026-07-27 17:47 JournalArticle 2979507 VALIDATED true 0 2015-12-04T17:13:35.000+0000 false 2979507 2026-07-19T08:51:11.850+0000 2024-12-06T17:40:04.727+0000 2015-12-04T11:33:32.000+0000 true 10006399 Nagy Judit /api/author/10006399 Author true 10006399 2024-01-27T17:08:47.778+0000 2024-12-06T17:40:04.736+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Lewis, EJ Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. true true /api/journal/1394667 REVIEWED true false 1394667 false 1394667 true 0028-4793 1533-4406 Journal FOREIGN 345 12 851 860 851 10 2001 BACKGROUND: It is unknown whether either the angiotensin-II-receptor blocker irbesartan or the calcium-channel blocker amlodipine slows the progression of nephropathy in patients with type 2 diabetes independently of its capacity to lower the systemic blood pressure. METHODS: We randomly assigned 1715 hypertensive patients with nephropathy due to type 2 diabetes to treatment with irbesartan (300 mg daily), amlodipine (10 mg daily), or placebo. The target blood pressure was 135/85 mm Hg or less in all groups. We compared the groups with regard to the time to the primary composite end point of a doubling of the base-line serum creatinine concentration, the development of end-stage renal disease, or death from any cause. We also compared them with regard to the time to a secondary, cardiovascular composite end point. RESULTS: The mean duration of follow-up was 2.6 years. Treatment with irbesartan was associated with a risk of the primary composite end point that was 20 percent lower than that in the placebo group (P=0.02) and 23 percent lower than that in the amlodipine group (P=0.006). The risk of a doubling of the serum creatinine concentration was 33 percent lower in the irbesartan group than in the placebo group (P=0.003) and 37 percent lower in the irbesartan group than in the amlodipine group (P<0.001). Treatment with irbesartan was associated with a relative risk of end-stage renal disease that was 23 percent lower than that in both other groups (P=0.07 for both comparisons). These differences were not explained by differences in the blood pressures that were achieved. The serum creatinine concentration increased 24 percent more slowly in the irbesartan group than in the placebo group (P=0.008) and 21 percent more slowly than in the amlodipine group (P=0.02). There were no significant differences in the rates of death from any cause or in the cardiovascular composite end point. CONCLUSIONS: The angiotensin-II-receptor blocker irbesartan is effective in protecting against the progression of nephropathy due to type 2 diabetes. This protection is independent of the reduction in blood pressure it causes. 2015 636808 true true true false false NONE 2026-07-19 false true 10022754 Milánkovics Róbert /api/admin/10022754 Admin true 10022754 5291 0 5291 4849 20 5231 4334 4363 5076 5291 5291 4849 4849 4849 442 0 5291 4849 5291 4849 0 0 0 Folyóiratcikk Journal Article 24 5133 Könyvrészlet Chapter in Book 25 152 Könyv Book 23 6 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2001 0 34 29 34 29 2002 0 297 263 297 263 2003 0 385 343 385 343 2004 0 367 322 367 322 2005 0 408 361 408 361 2006 0 345 309 345 309 2007 0 313 274 313 274 2008 0 285 257 285 257 2009 0 294 264 294 264 2010 0 256 218 256 218 2011 0 243 222 243 222 2012 0 232 213 232 213 2013 0 175 155 175 155 2014 0 164 146 164 146 2015 0 138 129 138 129 2016 0 143 142 143 142 2017 0 126 124 126 124 2018 0 144 144 144 144 2019 0 113 112 113 112 2020 0 120 120 120 120 2021 0 137 137 137 137 2022 0 134 132 134 132 2023 0 140 138 140 138 2024 0 131 128 131 128 2025 0 125 125 125 125 2026 0 42 42 42 42 D1 true false false false 2015-12-04T17:13:35.000+0000 2015-12-04T11:39:16.000+0000 1 5 0 10 1 true Language 10002 /api/language/10002 Angol English true 2 true OrgAuthorship 93710697 /api/authorship/93710697 1 0.0 false false false true false false AuthorshipType 30 /api/authorshiptype/30 -29 true -29 true false true PersonAuthorship 6863305 /api/authorship/6863305 1 0.091 true false true Lewis EJ true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22527794 true PersonAuthorship 6863306 /api/authorship/6863306 2 0.09090909 false false Hunsicker LG true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22527793 true PersonAuthorship 6863307 /api/authorship/6863307 3 0.09090909 false false Clarke WR true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22527792 true PersonAuthorship 6863308 /api/authorship/6863308 4 0.09090909 false false Berl T true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22527791 true PersonAuthorship 6863309 /api/authorship/6863309 5 0.09090909 false false Pohl MA true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22527790 true PersonAuthorship 6863310 /api/authorship/6863310 6 0.09090909 false false Lewis JB true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22527789 true PersonAuthorship 6863311 /api/authorship/6863311 7 0.09090909 false false Ritz E true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22527788 true PersonAuthorship 6863312 /api/authorship/6863312 8 0.09090909 false false Atkins RC true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22527787 true PersonAuthorship 6863313 /api/authorship/6863313 9 0.09090909 false false Rohde R true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22527786 true PersonAuthorship 6863314 /api/authorship/6863314 10 0.09090909 false true Raz I true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22527785 true PersonAuthorship 93710696 /api/authorship/93710696 11 1.0 false false Author 10006399 /api/author/10006399 Nagy Judit true 10006399 true Nagy J false false true AuthorshipType 12 /api/authorshiptype/12 -11 true -11 true false true PublicationIdentifier 1042017 /api/publicationidentifier/1042017 PlainSource 6 /api/publicationsource/6 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true Keyword 1004288 /api/keyword/1004288 true 1004288 true Keyword 1045045 /api/keyword/1045045 true 1045045 true Keyword 1045047 /api/keyword/1045047 true 1045047 true Keyword 1056375 /api/keyword/1056375 true 1056375 true Keyword 1061121 /api/keyword/1061121 true 1061121 true Keyword 1081694 /api/keyword/1081694 true 1081694 true Keyword 1095424 /api/keyword/1095424 true 1095424 true Keyword 1110907 /api/keyword/1110907 true 1110907 true Keyword 1386344 /api/keyword/1386344 true 1386344 true SjrRating 6111470 /api/sjrrating/6111470 7 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true D1 DIRECT true 6111470 true /api/publication/2979507 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" >Lewis EJ ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hunsicker LG </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Clarke WR </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Berl T </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pohl MA </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lewis JB </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ritz E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Atkins RC </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rohde R </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Raz I<sup>**</sup> </span> </div> <div class="autype autype-11"> Kollaborációs közreműködő: <span class="author-name" mtid="10006399"><a href="/gui2/?type=authors&mode=browse&sel=10006399" target="_blank">Nagy J (<span class="authorship-author-name">Nagy Judit</span> <span class="authorAux-mtmt"> Nephrológia</span>) </a> </span> </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">Collaborative Study Group</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2979507" target="_blank">Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes.</a></div> <div> <span class="journal-title">NEW ENGLAND JOURNAL OF MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-4793">0028-4793</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1533-4406">1533-4406</a>)</span>: <span class="journal-volume">345</span> <span class="journal-issue">12</span> <span class="page"> pp 851-860 </span> <span class="year">(2001)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1056/NEJMoa011303" target="_blank" href="https://doi.org/10.1056/NEJMoa011303"> DOI </a> 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