https://m2.mtmt.hu/ eng 2026-03-05 17:48 JournalArticle 2959502 ADMIN_APPROVED true 0 2018-02-23T17:12:27.000+0000 false 2959502 2026-01-26T06:47:27.903+0000 2024-09-09T09:51:47.703+0000 2015-10-22T07:19:57.000+0000 true 220 Hangya Balázs /api/author/220 Author true 220 2024-09-09T09:51:04.530+0000 2024-09-09T09:51:04.530+0000 2024-09-09T09:51:48.009+0000 true 10003133 Boros Annamária /api/admin/10003133 Admin true 10003133 Admin 10003133 /api/admin/10003133 Boros Annamária true 10003133 true 2024-09-13T11:56:08.998+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Hangya, B Central Cholinergic Neurons Are Rapidly Recruited by Reinforcement Feedback. true true /api/journal/934 REVIEWED true false 934 false 934 true 0092-8674 1097-4172 Journal FOREIGN 162 5 1155 1168 1155 14 2015 Basal forebrain cholinergic neurons constitute a major neuromodulatory system implicated in normal cognition and neurodegenerative dementias. Cholinergic projections densely innervate neocortex, releasing acetylcholine to regulate arousal, attention, and learning. However, their precise behavioral function is poorly understood because identified cholinergic neurons have never been recorded during behavior. To determine which aspects of cognition their activity might support, we recorded cholinergic neurons using optogenetic identification in mice performing an auditory detection task requiring sustained attention. We found that a non-cholinergic basal forebrain population-but not cholinergic neurons-were correlated with trial-to-trial measures of attention. Surprisingly, cholinergic neurons responded to reward and punishment with unusual speed and precision (18 +/- 3 ms). Cholinergic responses were scaled by the unexpectedness of reinforcement and were highly similar across neurons and two nuclei innervating distinct cortical areas. These results reveal that the cholinergic system broadcasts a rapid and precisely timed reinforcement signal, supporting fast cortical activation and plasticity. 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0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2015 0 2 1 2 1 2016 0 24 24 24 24 2017 0 22 20 22 20 2018 0 31 27 31 27 2019 0 42 41 42 41 2020 0 26 20 26 20 2021 0 44 42 44 42 2022 0 31 29 31 29 2023 0 24 22 24 22 2024 0 32 31 32 31 2025 0 19 19 19 19 D1 false false false false 2016-01-20T08:21:13.000+0000 2015-10-22T07:21:13.000+0000 Lendület Rendszer-Neurobiológia Kutatócsoport (KOKI) 1 12 1 4 0 true 10003133 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 6725717 /api/authorship/6725717 1 0.25 true false true Author 220 /api/author/220 Hangya Balázs true 220 true Hangya B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22254350 true PersonAuthorship 6725718 /api/authorship/6725718 2 0.25 false false Ranade SP true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22254349 true PersonAuthorship 6725719 /api/authorship/6725719 3 0.25 false false Lorenc M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22254348 true PersonAuthorship 6725720 /api/authorship/6725720 4 0.25 false true Kepecs A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22254347 true PublicationIdentifier 1027014 /api/publicationidentifier/1027014 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1016/j.cell.2015.07.057 https://doi.org/10.1016/j.cell.2015.07.057 false 1231560 true PublicationIdentifier 1027016 /api/publicationidentifier/1027016 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL http://real.mtak.hu/@@@ true true 36 true GREEN true NO 33424 http://real.mtak.hu/33424 false 1310353 true PublicationIdentifier 1027012 /api/publicationidentifier/1027012 PlainSource 1 /api/publicationsource/1 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NO 26317475 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26317475&dopt=Abstract false 1231561 true Classification 12125 /api/classification/12125 true true Classification 10545 /api/classification/10545 true true Classification 12347 /api/classification/12347 true true SjrRating 11007979 /api/sjrrating/11007979 1 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1301 /api/classificationexternal/1301 true 1301 true D1 DIRECT true true /api/publication/2959502 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="220"><a href="/gui2/?type=authors&mode=browse&sel=220" target="_blank">Hangya B ✉ (<span class="authorship-author-name">Hangya Balázs</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Lendület Laboratory of System-Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ranade SP </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lorenc M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kepecs A </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2959502" target="_blank">Central Cholinergic Neurons Are Rapidly Recruited by Reinforcement Feedback.</a></div> <div> <span class="journal-title">CELL</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0092-8674">0092-8674</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1097-4172">1097-4172</a>)</span>: <span class="journal-volume">162</span> <span class="journal-issue">5</span> <span class="page"> pp 1155-1168 </span> <span class="year">(2015)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.cell.2015.07.057" target="_blank" href="https://doi.org/10.1016/j.cell.2015.07.057"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="33424" target="_blank" href="http://real.mtak.hu/33424"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000360589900023" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000360589900023"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84940382102" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84940382102"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="26317475" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26317475&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 297</span> | Independent citation: 276 | Self citation: 21 | Unknown citation: 0 | Number of citations in WoS: 287 | Number of citations in Scopus:&nbsp;280 | WoS/Scopus assigned:&nbsp;297 | Number of citations with DOI:&nbsp;297 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2959502&sort=publishedYear,desc&sort=title"> Number of cited publications: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2959502</span> | <span class="status-data status-ADMIN_APPROVED"> Admin approved </span> <span class="oldId">Old id: 2959502</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="funder"> National Institute of Neurological Disorders and Stroke(R01NS075531), Seventh Framework Programme(FP7), National Institute of Neurological Disorders and Stroke(NINDS, R01NS075531) </div> <div class="lastModified">Last Modified: 2024.09.09. 11:51 Annamária Boros (MTMT Központi admin) </div> <div class="lockedBy">Centrally managed 2024.09.13. 13:56 Annamária Boros (MTMT Központi admin) </div> </div></div>