https://m2.mtmt.hu/ eng 2026-10-24 12:54 JournalArticle 2959484 VALIDATED true Laboratory of Molecular Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, H-1450, Hungary Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u. 43, Budapest, H-1083, Hungary Cited By :68 Export Date: 9 June 2023 CODEN: NEPHB Correspondence Address: Sperlágh, B.; Department of Pharmacology, Szigony u. 43, Hungary; email: sperlagh@koki.hu Chemicals/CAS: adenosine, 58-61-7; adenosine triphosphate, 15237-44-2, 56-65-5, 987-65-5; Adenosine; Adenosine Triphosphate; Inflammasomes; Inflammation Mediators; Receptors, Purinergic P1; Receptors, Purinergic P2 Funding details: KTIA_13_NAP-A-III/1 Funding details: NN107234 Funding details: European Research Council, ERC, 294313 -SERRACO Funding details: Hungarian Scientific Research Fund, OTKA, 107234 Funding details: Magyar Tudományos Akadémia, MTA, 1255/215/2015/KIF Funding text 1: This study was supported by research grants from the Hungarian Research and Development Fund (Grant NN107234 to B.S.), the European Research Council (Grant 294313 -SERRACO to B.S.), and the Hungarian Brain Research Program [ KTIA_13_NAP-A-III/1 to B.S.]. Ed Beamer is the recipient of the postdoctoral fellowship of the Hungarian Academy of Sciences ( 1255/215/2015/KIF ). 0 2018-07-02T22:20:06.000+0000 false 2959484 2026-10-17T09:24:20.670+0000 2023-02-02T13:43:12.312+0000 2015-10-22T06:51:42.000+0000 true 10008942 Sperlágh Beáta /api/author/10008942 Author true 10008942 2026-01-12T09:29:26.696+0000 2026-01-12T09:29:26.696+0000 2023-02-02T13:43:12.693+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 Admin 10066925 /api/admin/10066925 Nemec Évi true true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2024-10-17T16:20:19.023+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Beamer, E Purinergic mechanisms in neuroinflammation: An update from molecules to behavior true true /api/journal/3361 REVIEWED true false 3361 false 3361 true 0028-3908 1873-7064 Journal FOREIGN 104 SI 94 104 94 11 2016 The principle functions of neuroinflammation are to limit tissue damage and promote tissue repair in response to pathogens or injury. While neuroinflammation has utility, pathophysiological inflammatory responses, to some extent, underlie almost all neuropathology. Understanding the mechanisms that control the three stages of inflammation (initiation, propagation and resolution) is therefore of critical importance for developing treatments for diseases of the central nervous system. The purinergic signaling system, involving adenosine, ATP and other purines, plus a host of P1 and P2 receptor subtypes, controls inflammatory responses in complex ways. Activation of the inflammasome, leading to release of pro-inflammatory cytokines, activation and migration of microglia and altered astroglial function are key regulators of the neuroinflammatory response. Here, we review the role of P1 and P2 receptors in mediating these processes and examine their contribution to disorders of the nervous system. Firstly, we give an overview of the concept of neuroinflammation. We then discuss the contribution of P2X, P2Y and P1 receptors to the underlying processes, including a discussion of cross-talk between these different pathways. Finally, we give an overview of the current understanding of purinergic contributions to neuroinflammation in the context of specific disorders of the central nervous system, with special emphasis on neuropsychiatric disorders, characterized by chronic low grade inflammation or maternal inflammation. An understanding of the important purinergic contribution to neuroinflammation underlying neuropathology is likely to be a necessary step towards the development of effective interventions. true true 2015 696233 true true true false true false GREEN GREEN 2026-10-17 true https://real.mtak.hu/33700 93 0 93 82 9 93 92 84 90 93 93 82 82 82 11 0 93 82 93 82 0 6 6 Folyóiratcikk Journal Article 24 89 Könyvrészlet Chapter in Book 25 4 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2016 0 4 2 4 2 2017 0 12 11 12 11 2018 0 10 9 10 9 2019 0 13 9 13 9 2020 0 8 7 8 7 2021 0 13 12 13 12 2022 0 7 6 7 6 2023 0 11 11 11 11 2024 0 6 6 6 6 2025 0 2 2 2 2 2026 0 7 7 7 7 D1 false false false false 2016-01-20T07:54:02.000+0000 2015-10-22T06:54:02.000+0000 Molekuláris Farmakológia Kutatócsoport (KOKI / GYO) 6 26 1 7 0 true 10066925 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 6725670 /api/authorship/6725670 1 0.14285715 true false Beamer E true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22254292 true PersonAuthorship 6725671 /api/authorship/6725671 2 0.14285715 false false Author 10052098 /api/author/10052098 Gölöncsér Flóra true 10052098 true Goloncser F true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22254291 true PersonAuthorship 6725672 /api/authorship/6725672 3 0.14285715 false false Author 10048592 /api/author/10048592 Horváth Gergely true 10048592 true Horvath G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22254290 true PersonAuthorship 6725673 /api/authorship/6725673 4 0.14285715 false false Author 10060086 /api/author/10060086 Bekő Katinka true 10060086 true Beko K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22254289 true PersonAuthorship 6725674 /api/authorship/6725674 5 0.14285715 false false Author 10055678 /api/author/10055678 Bereczkiné Otrokocsi Lilla true 10055678 true Otrokocsi L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22254288 true PersonAuthorship 6725675 /api/authorship/6725675 6 0.14285715 false false Author 10057984 /api/author/10057984 Koványi Bence true 10057984 true Kovanyi B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22254287 true PersonAuthorship 6725676 /api/authorship/6725676 7 0.143 false true true Author 10008942 /api/author/10008942 Sperlágh Beáta true 10008942 true Sperlagh B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22254286 true PublicationIdentifier 1026987 /api/publicationidentifier/1026987 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1016/j.neuropharm.2015.09.019 https://doi.org/10.1016/j.neuropharm.2015.09.019 false 1231530 true PublicationIdentifier 1026989 /api/publicationidentifier/1026989 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GREEN true NO 33700 https://real.mtak.hu/33700 false 1312432 true PublicationIdentifier 1026985 /api/publicationidentifier/1026985 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000377320300009 https://www.webofscience.com/wos/woscc/full-record/000377320300009 false 1750769 true PublicationIdentifier 1026986 /api/publicationidentifier/1026986 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84968877202 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84968877202 false 1402526 true PublicationIdentifier 1026988 /api/publicationidentifier/1026988 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 26384652 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26384652&dopt=Abstract false 1231531 true Classification 12125 /api/classification/12125 true true SjrRating 10955187 /api/sjrrating/10955187 19 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3004 /api/classificationexternal/3004 true 3004 true D1 DIRECT true true /api/publication/2959484 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Beamer E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052098"><a href="/gui2/?type=authors&mode=browse&sel=10052098" target="_blank">Goloncser F (<span class="authorship-author-name">Gölöncsér Flóra</span> <span class="authorAux-mtmt"> idegtudományok</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Molecular Pharmacology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048592"><a href="/gui2/?type=authors&mode=browse&sel=10048592" target="_blank">Horvath G (<span class="authorship-author-name">Horváth Gergely</span> <span class="authorAux-mtmt"> biológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Molecular Pharmacology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060086"><a href="/gui2/?type=authors&mode=browse&sel=10060086" target="_blank">Beko K (<span class="authorship-author-name">Bekő Katinka</span> <span class="authorAux-mtmt"> állatorvosi mikrobiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055678"><a href="/gui2/?type=authors&mode=browse&sel=10055678" target="_blank">Otrokocsi L (<span class="authorship-author-name">Bereczkiné Otrokocsi Lilla</span> <span class="authorAux-mtmt"> élettudomány</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Molecular Pharmacology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057984"><a href="/gui2/?type=authors&mode=browse&sel=10057984" target="_blank">Kovanyi B (<span class="authorship-author-name">Koványi Bence</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008942"><a href="/gui2/?type=authors&mode=browse&sel=10008942" target="_blank">Sperlagh B ✉ (<span class="authorship-author-name">Sperlágh Beáta</span> <span class="authorAux-mtmt"> Neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Molecular Pharmacology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2959484" target="_blank">Purinergic mechanisms in neuroinflammation: An update from molecules to behavior</a></div> <div> <span class="journal-title">NEUROPHARMACOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-3908">0028-3908</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1873-7064">1873-7064</a>)</span>: <span class="journal-volume">104</span> <span class="journal-issue">SI</span> <span class="page"> pp 94-104 </span> <span class="year">(2016)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.neuropharm.2015.09.019" target="_blank" href="https://doi.org/10.1016/j.neuropharm.2015.09.019"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="33700" target="_blank" href="https://real.mtak.hu/33700"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000377320300009" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000377320300009"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84968877202" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84968877202"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="26384652" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26384652&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 93</span> | Independent citation: 82 | Self citation: 11 | Unknown citation: 0 | Number of citations in WoS: 84 | Number of citations in Scopus:&nbsp;90 | WoS/Scopus assigned:&nbsp;93 | Number of citations with DOI:&nbsp;92 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2959484&sort=publishedYear,desc&sort=title"> Number of cited publications: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2959484</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 2959484</span> | Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2023.02.02. 14:43 Rita Tichy (SE_KK_Admin5_TR, admin) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:20 Évi Nemec (MTMT Központi 3, admin) Gusztáv Ladányi (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Laboratory of Molecular Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, H-1450, Hungary Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u. 43, Budapest, H-1083, Hungary Cited By :68 Export Date: 9 June 2023 ...</pre> </div></div>