https://m2.mtmt.hu/ eng 2026-06-25 13:27 JournalArticle 2946565 APPROVED true Institute of Genetics, Biological Research Centre, Hungarian Academy of Sciences, 62 Temesvári krt, Szeged, 6726, Hungary Stem Cell Biology Unit, National Blood Service, Budapest, Hungary Cited By :38 Export Date: 10 February 2021 CODEN: SCDTA Correspondence Address: Czibula, A.; Institute of Genetics, Biological Research Centre, Hungarian Academy of Sciences, 62 Temesvári krt, Hungary 0 2017-05-25T07:41:43.000+0000 false 2946565 2026-05-17T01:13:02.413+0000 2023-09-19T16:20:43.934+0000 2015-09-24T08:47:31.000+0000 true 10018677 Berkes Kata /api/admin/10018677 Admin true 10018677 2026-02-09T11:07:58.815+0000 2015-09-24T09:00:02.000+0000 true 10018677 Berkes Kata /api/admin/10018677 Admin true 10018677 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szabo, Eniko Licensing by Inflammatory Cytokines Abolishes Heterogeneity of Immunosuppressive Function of Mesenchymal Stem Cell Population true true /api/journal/10001383 REVIEWED true false 10001383 false 10001383 true 1547-3287 1557-8534 Journal FOREIGN 24 18 2171 2180 2171 10 2015 When mesenchymal stem cells (MSCs) are used for therapy of immunological pathologies, they get into an inflammatory environment, altering the effectiveness of the treatment. To establish the impact of environmental inflammatory factors on MSCs' immunofunction in the mirror of intrinsic heterogeneity of mouse MSC population, individual MSC clones were generated and characterized. Adipogenic but not osteogenic differentiation and pro-angiogenic activity of five independent MSC cell lines were similar. Regarding osteogenic differentiation, clones MSC3 and MSC6 exhibited poorer capacity than MSC2, MSC4, and MSC5. To study the immunosuppressive heterogeneity, in vitro and in vivo experiments have been carried out using T-cell proliferation assay and delayed-type hypersensitivity (DTH) response, respectively. A remarkable difference was found between the clones in their ability to inhibit T-cell proliferation in the following order: MSC2MSC5>MSC4>MSC3>>MSC6. Nevertheless, the differences between the immunosuppressive activities of the individual clones disappeared on pretreatment of the cells with pro-inflammatory cytokines, a procedure called licensing. Stimulation of all clones with IFN- and TNF- resulted in elevation of their inhibitory capability to a similar level. Nitric oxide (NO) and prostaglandin E2 (PGE2) were identified as major mediators of immunofunction of the MSC clones. The earlier findings were also supported by in vivo results. Without licensing, MSC2 inhibited DTH response, while MSC6 did not affect DTH response. In contrast, prestimulation of MSC6 with inflammatory cytokines resulted in strong suppression by this clone as well. Here, we have showed that MSC population is functionally heterogeneous in terms of immunosuppressive function; however, this variability is largely reduced under pro-inflammatory conditions. 2015 273599 true true true false true false GREEN GREEN 2026-05-17 true http://real.mtak.hu/28815 true 10025655 Vasas Lívia /api/admin/10025655 Admin true 10025655 84 0 84 80 3 84 84 82 69 84 84 80 80 80 4 0 84 80 84 80 0 4 4 Folyóiratcikk Journal Article 24 83 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2016 0 6 5 6 5 2017 0 7 6 7 6 2018 0 6 6 6 6 2019 0 7 7 7 7 2020 0 12 10 12 10 2021 0 8 8 8 8 2022 0 12 12 12 12 2023 0 8 8 8 8 2024 0 9 9 9 9 2025 0 7 7 7 7 2026 0 2 2 2 2 Q1 false 10000260,10013040 false false false 2015-09-24T09:00:02.000+0000 2015-09-24T08:53:46.000+0000 Genetikai Intézet (HRN SZBK) 10 42 1 10 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 6699470 /api/authorship/6699470 1 0.1 true false Author 10031607 /api/author/10031607 Szabó Enikő true 10031607 true Szabo Eniko true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22204966 true PersonAuthorship 6699471 /api/authorship/6699471 2 0.1 false false Author 10013040 /api/author/10013040 Fajka-Boja Roberta true 10013040 true Fajka-Boja Roberta true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22204965 true PersonAuthorship 6699472 /api/authorship/6699472 3 0.1 false false Author 10030596 /api/author/10030596 Kriston-Pál Éva true 10030596 true Kriston-Pal Eva true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22204964 true PersonAuthorship 6699473 /api/authorship/6699473 4 0.1 false false Author 10048320 /api/author/10048320 Hornung Ákos true 10048320 true Hornung Akos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22204963 true PersonAuthorship 6699474 /api/authorship/6699474 5 0.1 false false Author 10051196 /api/author/10051196 Makra Ildikó true 10051196 true Makra Ildiko true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22204962 true PersonAuthorship 6699475 /api/authorship/6699475 6 0.1 false false Author 10043361 /api/author/10043361 Kudlik Gyöngyi true 10043361 true Kudlik Gyoengyi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22204961 true PersonAuthorship 6699476 /api/authorship/6699476 7 0.1 false false Author 10004551 /api/author/10004551 Uher Ferenc true 10004551 true Uher Ferenc true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22204960 true PersonAuthorship 6699477 /api/authorship/6699477 8 0.1 false false Author 10000260 /api/author/10000260 Katona Róbert László true 10000260 true Katona Robert Laszlo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22204959 true PersonAuthorship 6699478 /api/authorship/6699478 9 0.1 false false Author 10008944 /api/author/10008944 Monostori Éva true 10008944 true Monostori Eva true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22204958 true PersonAuthorship 6699479 /api/authorship/6699479 10 0.1 false true true Author 10018848 /api/author/10018848 Czibula Ágnes true 10018848 true Czibula Agnes true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22204957 true PublicationIdentifier 1019404 /api/publicationidentifier/1019404 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1089/scd.2014.0581 https://doi.org/10.1089/scd.2014.0581 false 1215113 true PublicationIdentifier 1019406 /api/publicationidentifier/1019406 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL http://real.mtak.hu/@@@ true true 36 true GREEN false NO 28815 http://real.mtak.hu/28815 false 1217416 true PublicationIdentifier 1019402 /api/publicationidentifier/1019402 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000360662900009 https://www.webofscience.com/wos/woscc/full-record/000360662900009 false 1215112 true PublicationIdentifier 1019403 /api/publicationidentifier/1019403 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84940908106 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84940908106 false 1591715 true PublicationIdentifier 1019405 /api/publicationidentifier/1019405 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 26153898 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26153898&dopt=Abstract false 1215111 true PublicationIdentifier 1019407 /api/publicationidentifier/1019407 SwordSource 90 /api/publicationsource/90 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true SZTE Publicatio SZTE Publicatio http://publicatio.bibl.u-szeged.hu/@@@ true true 90 true RESTRICTED false IDENTICAL 8846 http://publicatio.bibl.u-szeged.hu/8846 false 1392411 true Classification 12125 /api/classification/12125 true true Classification 10545 /api/classification/10545 true true Classification 12215 /api/classification/12215 true true Classification 11047 /api/classification/11047 true true SjrRating 11027810 /api/sjrrating/11027810 22 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2720 /api/classificationexternal/2720 true 2720 true Q1 DIRECT true true /api/publication/2946565 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10031607"><a href="/gui2/?type=authors&mode=browse&sel=10031607" target="_blank">Szabo Eniko (<span class="authorship-author-name">Szabó Enikő</span> <span class="authorAux-mtmt"> genetika</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Központ">MTA SZBK</span>/Institute of Genetics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013040"><a href="/gui2/?type=authors&mode=browse&sel=10013040" target="_blank">Fajka-Boja Roberta (<span class="authorship-author-name">Fajka-Boja Roberta</span> <span class="authorAux-mtmt"> Molekuláris és sejtbiológia, immunológia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Központ">MTA SZBK</span>/Institute of Genetics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10030596"><a href="/gui2/?type=authors&mode=browse&sel=10030596" target="_blank">Kriston-Pal Eva (<span class="authorship-author-name">Kriston-Pál Éva</span> <span class="authorAux-mtmt"> tumorbiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Központ">MTA SZBK</span>/Institute of Genetics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048320"><a href="/gui2/?type=authors&mode=browse&sel=10048320" target="_blank">Hornung Akos (<span class="authorship-author-name">Hornung Ákos</span> <span class="authorAux-mtmt"> immunológia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Központ">MTA SZBK</span>/Institute of Genetics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10051196"><a href="/gui2/?type=authors&mode=browse&sel=10051196" target="_blank">Makra Ildiko (<span class="authorship-author-name">Makra Ildikó</span> <span class="authorAux-mtmt"> biológia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Központ">MTA SZBK</span>/Institute of Genetics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043361"><a href="/gui2/?type=authors&mode=browse&sel=10043361" target="_blank">Kudlik Gyoengyi (<span class="authorship-author-name">Kudlik Gyöngyi</span> <span class="authorAux-mtmt"> molekuláris sejtbiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10004551"><a href="/gui2/?type=authors&mode=browse&sel=10004551" target="_blank">Uher Ferenc (<span class="authorship-author-name">Uher Ferenc</span> <span class="authorAux-mtmt"> Őssejtbiológia, immunológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000260"><a href="/gui2/?type=authors&mode=browse&sel=10000260" target="_blank">Katona Robert Laszlo (<span class="authorship-author-name">Katona Róbert László</span> <span class="authorAux-mtmt"> Molekuláris és sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Központ">MTA SZBK</span>/Institute of Genetics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008944"><a href="/gui2/?type=authors&mode=browse&sel=10008944" target="_blank">Monostori Eva (<span class="authorship-author-name">Monostori Éva</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Központ">MTA SZBK</span>/Institute of Genetics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018848"><a href="/gui2/?type=authors&mode=browse&sel=10018848" target="_blank">Czibula Agnes ✉ (<span class="authorship-author-name">Czibula Ágnes</span> <span class="authorAux-mtmt"> Molekuláris genetika</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Központ">MTA SZBK</span>/Institute of Genetics</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2946565" target="_blank">Licensing by Inflammatory Cytokines Abolishes Heterogeneity of Immunosuppressive Function of Mesenchymal Stem Cell Population</a></div> <div> <span class="journal-title">STEM CELLS AND DEVELOPMENT</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1547-3287">1547-3287</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1557-8534">1557-8534</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">18</span> <span class="page"> pp 2171-2180 </span> <span class="year">(2015)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1089/scd.2014.0581" target="_blank" href="https://doi.org/10.1089/scd.2014.0581"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="28815" target="_blank" href="http://real.mtak.hu/28815"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000360662900009" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000360662900009"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84940908106" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84940908106"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="26153898" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26153898&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_RESTRICTED" title=" Restricted "> <a style="color:blue" title="8846" target="_blank" href="http://publicatio.bibl.u-szeged.hu/8846"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Hematology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Developmental Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 84</span> | Independent citation: 80 | Self citation: 4 | Unknown citation: 0 | Number of citations in WoS: 82 | Number of citations in Scopus:&nbsp;69 | WoS/Scopus assigned:&nbsp;84 | Number of citations with DOI:&nbsp;84 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2946565&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2946565</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 2946565</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="lastModified">Last Modified: 2023.09.19. 18:20 Gusztáv Ladányi (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Institute of Genetics, Biological Research Centre, Hungarian Academy of Sciences, 62 Temesvári krt, Szeged, 6726, Hungary Stem Cell Biology Unit, National Blood Service, Budapest, Hungary Cited By :38 Export Date: 10 February 2021 CODEN: SCDTA Correspondence Address: Czibula, ...</pre> </div></div>