https://m2.mtmt.hu/ hun 2026-05-30 14:33 JournalArticle 2946565 APPROVED true Institute of Genetics, Biological Research Centre, Hungarian Academy of Sciences, 62 Temesvári krt, Szeged, 6726, Hungary Stem Cell Biology Unit, National Blood Service, Budapest, Hungary Cited By :38 Export Date: 10 February 2021 CODEN: SCDTA Correspondence Address: Czibula, A.; Institute of Genetics, Biological Research Centre, Hungarian Academy of Sciences, 62 Temesvári krt, Hungary 0 2017-05-25T07:41:43.000+0000 false 2946565 2026-05-17T01:13:02.413+0000 2023-09-19T16:20:43.934+0000 2015-09-24T08:47:31.000+0000 true 10018677 Berkes Kata /api/admin/10018677 Admin true 10018677 2026-02-09T11:07:58.815+0000 2015-09-24T09:00:02.000+0000 true 10018677 Berkes Kata /api/admin/10018677 Admin true 10018677 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szabo, Eniko Licensing by Inflammatory Cytokines Abolishes Heterogeneity of Immunosuppressive Function of Mesenchymal Stem Cell Population true true /api/journal/10001383 REVIEWED true false 10001383 false 10001383 true 1547-3287 1557-8534 Journal FOREIGN 24 18 2171 2180 2171 10 2015 When mesenchymal stem cells (MSCs) are used for therapy of immunological pathologies, they get into an inflammatory environment, altering the effectiveness of the treatment. To establish the impact of environmental inflammatory factors on MSCs' immunofunction in the mirror of intrinsic heterogeneity of mouse MSC population, individual MSC clones were generated and characterized. Adipogenic but not osteogenic differentiation and pro-angiogenic activity of five independent MSC cell lines were similar. Regarding osteogenic differentiation, clones MSC3 and MSC6 exhibited poorer capacity than MSC2, MSC4, and MSC5. To study the immunosuppressive heterogeneity, in vitro and in vivo experiments have been carried out using T-cell proliferation assay and delayed-type hypersensitivity (DTH) response, respectively. A remarkable difference was found between the clones in their ability to inhibit T-cell proliferation in the following order: MSC2MSC5>MSC4>MSC3>>MSC6. Nevertheless, the differences between the immunosuppressive activities of the individual clones disappeared on pretreatment of the cells with pro-inflammatory cytokines, a procedure called licensing. Stimulation of all clones with IFN- and TNF- resulted in elevation of their inhibitory capability to a similar level. Nitric oxide (NO) and prostaglandin E2 (PGE2) were identified as major mediators of immunofunction of the MSC clones. The earlier findings were also supported by in vivo results. Without licensing, MSC2 inhibited DTH response, while MSC6 did not affect DTH response. In contrast, prestimulation of MSC6 with inflammatory cytokines resulted in strong suppression by this clone as well. 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autype0"> <span class="author-name" mtid="10031607"><a href="/gui2/?type=authors&mode=browse&sel=10031607" target="_blank">Szabo Eniko (<span class="authorship-author-name">Szabó Enikő</span> <span class="authorAux-mtmt"> genetika</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013040"><a href="/gui2/?type=authors&mode=browse&sel=10013040" target="_blank">Fajka-Boja Roberta (<span class="authorship-author-name">Fajka-Boja Roberta</span> <span class="authorAux-mtmt"> Molekuláris és sejtbiológia, immunológia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10030596"><a href="/gui2/?type=authors&mode=browse&sel=10030596" target="_blank">Kriston-Pal Eva (<span class="authorship-author-name">Kriston-Pál Éva</span> <span class="authorAux-mtmt"> tumorbiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048320"><a href="/gui2/?type=authors&mode=browse&sel=10048320" target="_blank">Hornung Akos (<span class="authorship-author-name">Hornung Ákos</span> <span class="authorAux-mtmt"> immunológia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10051196"><a href="/gui2/?type=authors&mode=browse&sel=10051196" target="_blank">Makra Ildiko (<span class="authorship-author-name">Makra Ildikó</span> <span class="authorAux-mtmt"> biológia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043361"><a href="/gui2/?type=authors&mode=browse&sel=10043361" target="_blank">Kudlik Gyoengyi (<span class="authorship-author-name">Kudlik Gyöngyi</span> <span class="authorAux-mtmt"> molekuláris sejtbiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10004551"><a href="/gui2/?type=authors&mode=browse&sel=10004551" target="_blank">Uher Ferenc (<span class="authorship-author-name">Uher Ferenc</span> <span class="authorAux-mtmt"> Őssejtbiológia, immunológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000260"><a href="/gui2/?type=authors&mode=browse&sel=10000260" target="_blank">Katona Robert Laszlo (<span class="authorship-author-name">Katona Róbert László</span> <span class="authorAux-mtmt"> Molekuláris és sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008944"><a href="/gui2/?type=authors&mode=browse&sel=10008944" target="_blank">Monostori Eva (<span class="authorship-author-name">Monostori Éva</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018848"><a href="/gui2/?type=authors&mode=browse&sel=10018848" target="_blank">Czibula Agnes ✉ (<span class="authorship-author-name">Czibula Ágnes</span> <span class="authorAux-mtmt"> Molekuláris genetika</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2946565" target="_blank">Licensing by Inflammatory Cytokines Abolishes Heterogeneity of Immunosuppressive Function of Mesenchymal Stem Cell Population</a></div> <div> <span class="journal-title">STEM CELLS AND DEVELOPMENT</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1547-3287">1547-3287</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1557-8534">1557-8534</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">18</span> <span class="page"> pp 2171-2180 </span> <span class="year">(2015)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1089/scd.2014.0581" target="_blank" href="https://doi.org/10.1089/scd.2014.0581"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="28815" target="_blank" href="http://real.mtak.hu/28815"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" 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Scopus - Cell Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Developmental Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 84</span> | Független: 80 | Függő: 4 | Nem jelölt: 0 | WoS jelölt: 82 | Scopus jelölt:&nbsp;69 | WoS/Scopus jelölt:&nbsp;84 | DOI jelölt:&nbsp;84 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2946565&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 2946565</span> | <span class="status-data status-APPROVED"> Nyilvános </span> <span class="oldId">Régi azonosító: 2946565</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="lastModified">Utolsó módosítás: 2023.09.19. 18:20 Ladányi Gusztáv (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Institute of Genetics, Biological Research Centre, Hungarian Academy of Sciences, 62 Temesvári krt, Szeged, 6726, Hungary Stem Cell Biology Unit, National Blood Service, Budapest, Hungary Cited By :38 Export Date: 10 February 2021 CODEN: SCDTA Correspondence Address: Czibula, ...</pre> </div></div>