https://m2.mtmt.hu/ hun 2026-04-30 01:48 JournalArticle 2941631 ADMIN_APPROVED true 0 2017-07-27T08:51:36.000+0000 false 2941631 2025-12-24T08:49:35.983+0000 2024-06-07T08:11:00.662+0000 2015-09-16T08:27:38.000+0000 true 10021517 xVégh Judit /api/admin/10021517 Admin true 10021517 2024-06-07T08:08:48.053+0000 2024-06-07T08:08:48.053+0000 2024-06-07T08:11:00.932+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kis, Viktor Specialized Cortex Glial Cells Accumulate Lipid Droplets in Drosophila melanogaster true true /api/journal/10007440 REVIEWED true false 10007440 false 10007440 true 1932-6203 Journal FOREIGN 10 7 e0131250 e0131250 19 2015 Lipid droplets (LDs) are common organelles of the majority of eukaryotic cell types. Their biological significance has been extensively studied in mammalian liver cells and white adipose tissue. Although the central nervous system contains the highest relative amount and the largest number of different lipid species, neither the spatial nor the temporal distribution of LDs has been described. In this study, we used the brain of the fruitfly, Drosophila melanogaster, to investigate the neuroanatomy of LDs. We demonstrated that LDs are exclusively localised in glial cells but not in neurons in the larval nervous system. We showed that the brain's LD pool, rather than being constant, changes dynamically during development and reaches its highest value at the beginning of metamorphosis. LDs are particularly enriched in cortex glial cells located close to the brain surface. These specialized superficial cortex glial cells contain the highest amount of LDs among glial cell types and encapsulate neuroblasts and their daughter cells. Superficial cortex glial cells, combined with subperineurial glial cells, express the Drosophila fatty acid binding protein (Dfabp), as we have demonstrated through light-and electron microscopic immunocytochemistry. To the best of our best knowledge this is the first study that describes LD neuroanatomy in the Drosophila larval brain. true true 2015 (Végh Judit (ELTE TTK BIO Adm); 2015.09.16. 10:13:38) true true true false false GOLD 2025-12-24 true https://doi.org/10.1371/journal.pone.0131250 true 10019782 Csámer Iván /api/admin/10019782 Admin true 10019782 55 0 55 55 2 55 55 52 50 54 54 54 54 55 0 0 55 55 55 55 0 1 1 Folyóiratcikk Journal Article 24 55 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció 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src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10020459"><a href="/gui2/?type=authors&mode=browse&sel=10020459" target="_blank">Kis Viktor ✉ (<span class="authorship-author-name">Kis Viktor</span> <span class="authorAux-mtmt"> Sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Anatómiai, Sejt- és Fejlődésbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053132"><a href="/gui2/?type=authors&mode=browse&sel=10053132" target="_blank">Barti Benjámin (<span class="authorship-author-name">Barti Benjámin</span> <span class="authorAux-mtmt"> idegtudomány</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011058"><a href="/gui2/?type=authors&mode=browse&sel=10011058" target="_blank">Lippai Mónika (<span 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Droplets in Drosophila melanogaster</a></div> <div> <span class="journal-title">PLOS ONE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1932-6203">1932-6203</a>)</span>: <span class="journal-volume">10</span> <span class="journal-issue">7</span> <span class="page"> Paper e0131250. 19 p. </span> <span class="year">(2015)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1371/journal.pone.0131250" target="_blank" href="https://doi.org/10.1371/journal.pone.0131250"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000358157600074" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000358157600074"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" 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