https://m2.mtmt.hu/ hun 2026-05-02 02:07 JournalArticle 2941590 VALIDATED true 0 2015-11-09T20:27:54.000+0000 false 2941590 2026-01-26T06:47:47.163+0000 2020-12-22T17:04:23.030+0000 2015-09-16T08:15:44.000+0000 true 10051003 Soltesz Ivan /api/author/10051003 Author Soltesz Ivan (Neurobiologia) true 10051003 2018-10-10T17:18:52.507+0000 2018-10-10T17:35:19.117+0000 2015-11-09T20:27:54.000+0000 true 10035645 Balazsa Tamás /api/admin/10035645 Admin Balazsa Tamás (MTMT külsős admin (2-3) - INAKTÍV) true 10035645 2015-11-09T20:27:54.000+0000 true 10035645 Balazsa Tamás /api/admin/10035645 Admin Balazsa Tamás (MTMT külsős admin (2-3) - INAKTÍV) true 10035645 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 LERESCHE, N true true /api/journal/1000011 REVIEWED JOURNAL OF PHYSIOLOGY-LONDON 0022-3751 1469-7793 true false 1000011 false 1000011 true 0022-3751 1469-7793 Journal FOREIGN 441 155 174 155 20 1991 1. Low-frequency membrane potential oscillations recorded intracellularly from thalamocortical (TC) cells of the rat and cat dorsal lateral geniculate nucleus (dLGN) and of the rat ventrobasal nucleus (VB) maintained in vitro were investigated. On the basis of their electrophysiological and pharmacological properties, four types of activity were distinguished and named: the pacemaker oscillations, the spindle-like oscillations, the 'very slow' oscillations and the 'N-methyl-D-aspartate' (NMDA) oscillations. 2. The pacemaker oscillations (95 out of 173 cells) consisted of rhythmic, large-amplitude (10-30 mV) depolarizations which occurred at a frequency of 1.8 +/- 0.3 Hz (range, 0.5-2.9 Hz) and could often give rise to single or a burst of action potentials. Pacemaker oscillations were observed when the membrane potential was moved negative to -55 and positive to -80 mV, but in a given cell the upper and lower limits of this voltage range were separated by only 13.1 +/- 0.5 mV. Above -45 mV tonic firing consisting of single action potentials was seen in the cells showing this or the other types of low-frequency oscillations. 3. The spindle-like oscillations were observed in thirty-nine (out of 173) TC cells and consisted of rhythmic (2.1 +/- 0.3 Hz), large-amplitude depolarizations (and often associated burst firing) similar to the pacemaker oscillations but occurring in discrete periods every 5-25 s and lasting for 1.5-28 s. The spindle-like oscillations were observed when the membrane potential was moved negative to -55 and positive to -80 mV and in two cells they were transformed into continuous pacemaker oscillations by depolarization of the membrane potential to -60 mV. 4. Pacemaker and spindle-like oscillations were unaffected by tetrodotoxin (TTX) or by selective blockade of NMDA, non-NMDA, GABA(A), GABA(B), nicotinic, muscarinic, alpha- and beta-noradrenergic receptors. 5. The 'very slow' oscillations consisted of a TTX-insensitive, slow hyperpolarization-depolarization sequence (5-15 mV in amplitude) which lasted up to 90 s and was observed in nine dLGN cells and in two VB cells. The pacemaker and the spindle-like oscillations were recorded in one cell each which also showed the 'very slow' oscillations. 6. The 'NMDA' oscillations were observed only in a 'Mg2+-free' medium (0 mM-Mg2+, 2-4 mM-Ca2+; 64 out of 72 cells) and consisted of large-amplitude (10-25 mV) depolarizations that did not occur at regular intervals and were intermixed with smaller depolarizations present on the baseline and on the failing phase of the larger ones. The 'NMDA' oscillations were voltage dependent (observed in the range from -60 to -85 mV), insensitive to TTX and had a frequency of 1-4 Hz. Application of selective NMDA receptor antagonists reversibly transformed the NMDA into the pacemaker or the spindle-like oscillations while blockade of non-NMDA receptors as well as the other receptors mentioned above (paragraph 4) had no effect on the 'NMDA' oscillations. 7. The pacemaker, the spindle-like and the 'very slow' oscillations were never observed in electrophysiologically identified rat and cat dLGN interneurones (n = 12). Similarly, in a 'Mg2+-free' medium, interneurones in the dLGN and cells in the ventral lateral geniculate nucleus did not show the 'NMDA' oscillations but only slow, small-amplitude (< 4 mV) depolarizations that were reversibly abolished by DL-2-amino-5-phosphono-valeric acid (25-mu-M). 8. These results indicate that (i) single TC cells in different thalamic nuclei of different species are capable of four types of low-frequency oscillatory activity that do not require the evoked rhythmic recruitment of other neurones and (ii) activation of the NMDA receptors by spontaneously released excitatory amino acid brings about the transformation of the pacemaker and the spindle-like oscillations into the 'NMDA' oscillations. 2015 (Bálint Eszter (MTMT 2-3); 2015.09.16. 09:33:17) true true true false false NONE 2026-01-26 false true 10035645 Balazsa Tamás /api/admin/10035645 Admin Balazsa Tamás (MTMT külsős admin (2-3) - INAKTÍV) true 10035645 189 0 189 151 3 189 136 188 75 189 189 151 151 151 38 0 189 151 189 151 0 6 6 Folyóiratcikk Journal Article 24 189 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 1991 0 1 0 1 0 1992 0 14 10 14 10 1993 0 13 13 13 13 1994 0 15 13 15 13 1995 0 8 7 8 7 1996 0 14 11 14 11 1997 0 15 10 15 10 1998 0 17 13 17 13 1999 0 9 8 9 8 2000 0 7 6 7 6 2001 0 5 5 5 5 2002 0 3 2 3 2 2003 0 3 3 3 3 2004 0 7 7 7 7 2005 0 1 0 1 0 2006 0 4 2 4 2 2007 0 1 1 1 1 2008 0 4 2 4 2 2009 0 4 3 4 3 2010 0 0 0 0 0 2011 0 2 1 2 1 2012 0 6 5 6 5 2013 0 2 2 2 2 2014 0 8 5 8 5 2015 0 5 5 5 5 2016 0 1 0 1 0 2017 0 0 0 0 0 2018 0 3 2 3 2 2019 0 3 3 3 3 2020 0 4 4 4 4 2021 0 1 1 1 1 2022 0 3 3 3 3 2023 0 2 1 2 1 2024 0 2 1 2 1 2025 0 2 2 2 2 false false false false 2015-11-09T20:27:54.000+0000 2015-09-16T08:55:00.000+0000 1 1 0 5 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 6687109 /api/authorship/6687109 LERESCHE, N 1 0.2 true false LERESCHE N true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 22183562 true PersonAuthorship 6687110 /api/authorship/6687110 LIGHTOWLER, S 2 0.2 false false LIGHTOWLER S true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 22183561 true PersonAuthorship 6687111 /api/authorship/6687111 SOLTESZ, I [Soltesz, Ivan (Neurobiologia), szerző] 3 0.2 false false Author 10051003 /api/author/10051003 Soltesz Ivan (Neurobiologia) Soltesz Ivan true 10051003 true SOLTESZ I true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 22183560 true PersonAuthorship 6687112 /api/authorship/6687112 JASSIKGERSCHENFELD, D 4 0.2 false false JASSIKGERSCHENFELD D true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 22183559 true PersonAuthorship 6687113 /api/authorship/6687113 CRUNELLI, V 5 0.2 false true CRUNELLI V true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false 22183558 true PublicationIdentifier 1015033 /api/publicationidentifier/1015033 WoS: A1991GE46100010 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL A1991GE46100010 https://www.webofscience.com/wos/woscc/full-record/A1991GE46100010 false 1206768 true PublicationIdentifier 1015034 /api/publicationidentifier/1015034 PubMed: 1840071 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 1840071 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1840071&dopt=Abstract false 1206769 true Classification 12125 /api/classification/12125 Általános orvostudomány true true Classification 10545 /api/classification/10545 Biológiai tudományok true true Classification 12347 /api/classification/12347 Egészségtudományok true true Keyword 257 /api/keyword/257 GUINEA-PIG true 257 true Keyword 720 /api/keyword/720 LATERAL GENICULATE-NUCLEUS true 720 true Keyword 821 /api/keyword/821 NMDA RECEPTORS true 821 true Keyword 982 /api/keyword/982 CENTRAL NERVOUS-SYSTEM true 982 true Keyword 1054466 /api/keyword/1054466 ELECTROPHYSIOLOGICAL PROPERTIES true 1054466 true Keyword 1207414 /api/keyword/1207414 RELAY NEURONS true 1207414 true Keyword 1298753 /api/keyword/1298753 POSTSYNAPTIC POTENTIALS true 1298753 true Keyword 1378296 /api/keyword/1378296 BURST DISCHARGES true 1378296 true Keyword 1378297 /api/keyword/1378297 PARKINSONIAN TREMOR true 1378297 true Keyword 1378299 /api/keyword/1378299 PIG THALAMIC NEURONS true 1378299 true Reference 2028537 /api/reference/2028537 1. 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LOW-FREQUENCY OSCILLATORY ACTIVITIES INTRINSIC TO RAT AND CAT THALAMOCORTICAL CELLS. (1991) JOURNAL OF PHYSIOLOGY-LONDON 0022-3751 1469-7793 441 155-174<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >LERESCHE N </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >LIGHTOWLER S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10051003"><a href="/gui2/?type=authors&mode=browse&sel=10051003" target="_blank">SOLTESZ I (<span class="authorship-author-name">Soltesz Ivan</span> <span class="authorAux-mtmt"> Neurobiologia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >JASSIKGERSCHENFELD D </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >CRUNELLI V </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2941590" target="_blank">LOW-FREQUENCY OSCILLATORY ACTIVITIES INTRINSIC TO RAT AND CAT THALAMOCORTICAL CELLS</a></div> <div> <span class="journal-title">JOURNAL OF PHYSIOLOGY-LONDON</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0022-3751">0022-3751</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1469-7793">1469-7793</a>)</span>: <span class="journal-volume">441</span> <span class="page"> pp 155-174 </span> <span class="year">(1991)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="A1991GE46100010" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/A1991GE46100010"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="1840071" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1840071&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 189</span> | Független: 151 | Függő: 38 | Nem jelölt: 0 | WoS jelölt: 188 | Scopus jelölt:&nbsp;75 | WoS/Scopus jelölt:&nbsp;189 | DOI jelölt:&nbsp;136 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2941590&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 2941590</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 2941590</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="lastModified">Utolsó módosítás: 2020.12.22. 18:04 Szuper Admin (admin) </div> </div></div>