https://m2.mtmt.hu/ eng 2026-10-22 22:02 JournalArticle 2937967 VALIDATED true Laboratories of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 43 Szigony St., Budapest, HU-1083, Hungary Laboratories of Integrative Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Department of Neurosciences, Faculty of Information Technology, Pázmány Péter Catholic University, Budapest, Hungary Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Tupper Research Institute, Tufts Medical Center, Boston, MA, United States Export Date: 17 August 2026; Cited By: 12; CODEN: NUNDA 0 2017-07-26T07:39:29.000+0000 false 2937967 2026-10-17T07:16:54.141+0000 2026-08-17T11:32:57.409+0000 2015-09-09T08:50:58.000+0000 true 10002755 Liposits Zsolt /api/author/10002755 Author true 10002755 2026-08-18T07:14:02.622+0000 2026-08-18T07:14:02.622+0000 2024-12-06T17:39:19.071+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Molnar, CS Altered Gene Expression Profile of the Hypothalamic Arcuate Nucleus of Male Mice Suggests Profound Developmental Changes in Peptidergic Signaling. true true /api/journal/3350 REVIEWED true false 3350 false 3350 true 0028-3835 1423-0194 Journal FOREIGN 103 3-4 369 382 369 14 2016 Neuropeptides of the hypothalamic arcuate nucleus (ARC) regulate important homeostatic and endocrine functions and also play critical roles in pubertal development. Altered peptidergic and amino acidergic neurotransmission accompanying pubertal maturation of the ARC are not fully understood. Here we studied the developmental shift in the gene expression profile of the ARC of male mice. RNA samples for quantitative RT-PCR studies were isolated from the ARC of day-14 infantile and day-60 adult male mice with laser-capture microdissection. The expression of 18 neuropeptide-, 15 neuropeptide receptor-, 4 sex steroid receptor and 6 classic neurotransmitter marker mRNAs were compared between the two timepoints. Adult animals showed increased mRNA levels encoding cocaine- and amphetamine-regulated transcript, galanin-like peptide, dynorphin, kisspeptin, proopiomelanocortin, proenkephalin and galanin and reduced expression of mRNAs for pituitary adenylate cyclase activating peptide, calcitonin gene-related peptide, neuropeptide Y, substance P, agouti-related protein, neurotensin and growth hormone-releasing hormone. From the neuropeptide receptors tested, melanocortin receptor-4 showed the most striking (5-fold) increase. Melanocortin receptor-3 and the Y1 and Y5 neuropeptide Y receptors increased 1.5-1.8-fold, whereas delta-opioid receptor and neurotensin receptor-1 transcripts were reduced by 27 and 21%, respectively. Androgen-, progesterone- and alpha-estrogen receptor transcripts increased by 54-72%. The mRNAs of glutamic acid decarboxylase 65, and 67, vesicular GABA transporter and choline acetyltransferase remained unchanged. Tyrosine hydroxylase mRNA increased by 44%, whereas type-2 vesicular glutamate transporter mRNA decreased by 43% by adulthood. Many of the developmental changes we revealed in this study suggest reduced inhibitory and/or enhanced excitatory neuropeptidergic drive on fertility in adult animals. (c) 2015 S. Karger AG, Basel. true true 2015 967435 true true true false true false GOLD 2026-10-17 true https://doi.org/10.1159/000439430 12 0 12 12 0 12 12 12 12 12 12 12 12 12 0 0 12 12 12 12 0 15 15 Folyóiratcikk Journal Article 24 12 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2017 0 1 1 1 1 2018 0 3 3 3 3 2019 0 0 0 0 0 2020 0 2 2 2 2 2021 0 2 2 2 2 2022 0 2 2 2 2 2023 0 0 0 0 0 2024 0 0 0 0 0 2025 0 1 1 1 1 2026 0 1 1 1 1 Q2 false false false false 2015-12-23T07:25:08.000+0000 2015-09-24T06:25:08.000+0000 Endokrin Neurobiológiai Kutatócsoport (KOKI / ENO); Információs Technológiai és Bionikai Kar (PPKE); Integratív Neuroendokrinológiai Kutatócsoport (HRN KOKI) 6 26 3 7 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 6672919 /api/authorship/6672919 1 0.14285715 true false Author 10019581 /api/author/10019581 Molnár Csilla true 10019581 true Molnar CS true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22161297 true PersonAuthorship 6672920 /api/authorship/6672920 2 0.14285715 false false Author 10014210 /api/author/10014210 Sárvári Miklós true 10014210 true Sarvari M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22161296 true PersonAuthorship 6672921 /api/authorship/6672921 3 0.14285715 false false Author 182 /api/author/182 Vastagh Csaba true 182 true Vastagh C true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22161295 true PersonAuthorship 6672922 /api/authorship/6672922 4 0.14285715 false false Maurnyi C true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22161294 true PersonAuthorship 6672923 /api/authorship/6672923 5 0.14285715 false false Author 10012354 /api/author/10012354 Fekete Csaba true 10012354 true Fekete C true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22161293 true PersonAuthorship 6672924 /api/authorship/6672924 6 0.143 false false Author 10002755 /api/author/10002755 Liposits Zsolt true 10002755 true Liposits Z true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22161292 true PersonAuthorship 6672925 /api/authorship/6672925 7 0.143 false true true Author 10011472 /api/author/10011472 Hrabovszky Erik true 10011472 true Hrabovszky E true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 22161291 true PublicationIdentifier 1012280 /api/publicationidentifier/1012280 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1159/000439430 https://doi.org/10.1159/000439430 false 1201150 true PublicationIdentifier 1012278 /api/publicationidentifier/1012278 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000375766500018 https://www.webofscience.com/wos/woscc/full-record/000375766500018 false 1547404 true PublicationIdentifier 16523801 /api/publicationidentifier/16523801 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true CLOSED 105459 https://real.mtak.hu/105459 false true PublicationIdentifier 1012279 /api/publicationidentifier/1012279 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84940751356 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84940751356 false 1323071 true PublicationIdentifier 1012281 /api/publicationidentifier/1012281 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 26338351 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26338351&dopt=Abstract false 1201151 true Classification 12125 /api/classification/12125 true true Classification 10545 /api/classification/10545 true true Classification 12215 /api/classification/12215 true true SjrRating 10931045 /api/sjrrating/10931045 9 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2807 /api/classificationexternal/2807 true 2807 true Q2 DIRECT true true /api/publication/2937967 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10019581"><a href="/gui2/?type=authors&mode=browse&sel=10019581" target="_blank">Molnar CS (<span class="authorship-author-name">Molnár Csilla</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Endocrine Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014210"><a href="/gui2/?type=authors&mode=browse&sel=10014210" target="_blank">Sarvari M (<span class="authorship-author-name">Sárvári Miklós</span> <span class="authorAux-mtmt"> Endokrin neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Endocrine Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="182"><a href="/gui2/?type=authors&mode=browse&sel=182" target="_blank">Vastagh C (<span class="authorship-author-name">Vastagh Csaba</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Endocrine Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Maurnyi C </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012354"><a href="/gui2/?type=authors&mode=browse&sel=10012354" target="_blank">Fekete C (<span class="authorship-author-name">Fekete Csaba</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Integratív Neuroendokrinológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002755"><a href="/gui2/?type=authors&mode=browse&sel=10002755" target="_blank">Liposits Z (<span class="authorship-author-name">Liposits Zsolt</span> <span class="authorAux-mtmt"> Neurobiológia, neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Endocrine Neurobiology; <span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011472"><a href="/gui2/?type=authors&mode=browse&sel=10011472" target="_blank">Hrabovszky E ✉ (<span class="authorship-author-name">Hrabovszky Erik</span> <span class="authorAux-mtmt"> Reproduktív endokrinológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Endocrine Neurobiology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2937967" target="_blank">Altered Gene Expression Profile of the Hypothalamic Arcuate Nucleus of Male Mice Suggests Profound Developmental Changes in Peptidergic Signaling.</a></div> <div> <span class="journal-title">NEUROENDOCRINOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-3835">0028-3835</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1423-0194">1423-0194</a>)</span>: <span class="journal-volume">103</span> <span class="journal-issue">3-4</span> <span class="page"> pp 369-382 </span> <span class="year">(2016)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1159/000439430" target="_blank" href="https://doi.org/10.1159/000439430"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000375766500018" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000375766500018"> WoS </a> </span> <span class="id identifier oa_CLOSED" title=" Closed "> <a style="color:black" title="105459" target="_blank" href="https://real.mtak.hu/105459"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84940751356" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84940751356"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="26338351" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26338351&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Endocrine and Autonomic Systems&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 12</span> | Independent citation: 12 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 12 | Number of citations in Scopus:&nbsp;12 | WoS/Scopus assigned:&nbsp;12 | Number of citations with DOI:&nbsp;12 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2937967&sort=publishedYear,desc&sort=title"> Number of cited publications: 15 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2937967</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 2937967</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2026.08.17. 13:32 Zsolt Heronyányi (PTE ÁOK admin 5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Laboratories of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 43 Szigony St., Budapest, HU-1083, Hungary Laboratories of Integrative Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Department of Neurosciences, Faculty of Information Technology, Pázmány ...</pre> </div></div>