https://m2.mtmt.hu/ hun 2026-10-25 13:46 JournalArticle 2931297 APPROVED true Institute of Genetics, Biological Research Centre HAS, Szeged, H-6726, Hungary Hungarian Academy of Sciences, Office for Subsidized Research Units, Budapest, H-1051, Hungary Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, 10461, NY, United States Export Date: 25 March 2025; Cited By: 42; Correspondence Address: J. Mihály; Institute of Genetics, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Temesvári krt 62, H-6726, Hungary; email: mihaly.jozsef@brc.mta.hu; CODEN: JNRSD 0 2016-04-29T14:19:31.000+0000 false 2931297 2026-10-17T06:09:22.376+0000 2025-04-02T18:18:00.505+0000 2015-08-24T08:48:37.000+0000 true 10045852 Patkósné Hanesz Andrea /api/admin/10045852 Admin true 10045852 2026-09-07T12:32:33.179+0000 2015-08-24T09:05:37.000+0000 true 10045852 Patkósné Hanesz Andrea /api/admin/10045852 Admin true 10045852 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Gombos, R The Formin DAAM Functions as Molecular Effector of the Planar Cell Polarity Pathway during Axonal Development in Drosophila true true /api/journal/2707 REVIEWED true false 2707 false 2707 true 0270-6474 1529-2401 Journal FOREIGN 35 28 10154 10167 10154 14 2015 Recent studies established that the planar cell polarity (PCP) pathway is critical for various aspects of nervous system development and function, including axonal guidance. Although it seems clear that PCP signaling regulates actin dynamics, the mechanisms through which this occurs remain elusive. Here, we establish a functional link between the PCP system and one specific actin regulator, the formin DAAM, which has previously been shown to be required for embryonic axonal morphogenesis and filopodia formation in the growth cone. We show that dDAAM also plays a pivotal role during axonal growth and guidance in the adult Drosophila mushroom body, a brain center for learning and memory. By using a combination of genetic and biochemical assays, we demonstrate that Wnt5 and the PCP signaling proteins Frizzled, Strabismus, and Dishevelled act in concert with the small GTPase Rac1 to activate the actin assembly functions of dDAAM essential for correct targeting of mushroom body axons. Collectively, these data suggest that dDAAM is used as a major molecular effector of the PCP guidance pathway. By uncovering a signaling system from the Wnt5 guidance cue to an actin assembly factor, we propose that the Wnt5/PCP navigation system is linked by dDAAM to the regulation of the growth cone actin cytoskeleton, and thereby growth cone behavior, in a direct way. 2015 808116 true true true false true false GREEN GREEN 2026-10-17 true https://real.mtak.hu/29683 46 0 45 35 7 44 45 44 39 45 45 35 35 36 10 0 46 36 45 35 0 8 8 Folyóiratcikk Journal Article 24 44 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 1 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2016 0 2 1 2 1 2017 0 4 2 4 2 2018 0 4 3 4 3 2019 0 3 3 3 3 2020 0 10 7 10 7 2021 0 6 6 6 6 2022 0 6 4 6 4 2023 0 3 2 3 2 2024 0 4 4 4 4 2025 0 3 3 3 3 2026 0 1 1 1 1 D1 false false false false 2015-08-24T09:05:37.000+0000 2015-08-24T09:05:36.000+0000 Genetikai Intézet (HRN SZBK); MTA-SZBK-NAP B Axon növekedés és regeneráció ku... 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/api/reference/2011020 56 10.1016/S0092-8674(04)00210-7 false true Reference 2011021 /api/reference/2011021 57 10.1016/j.conb.2013.09.002 false true /api/publication/2931297 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10024995"><a href="/gui2/?type=authors&mode=browse&sel=10024995" target="_blank">Gombos R (<span class="authorship-author-name">Gombos Rita I</span> <span class="authorAux-mtmt"> Genetika</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040911"><a href="/gui2/?type=authors&mode=browse&sel=10040911" target="_blank">Migh E (<span class="authorship-author-name">Migh Ede</span> <span class="authorAux-mtmt"> genetika</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10047278"><a href="/gui2/?type=authors&mode=browse&sel=10047278" target="_blank">Antal O (<span class="authorship-author-name">Antal Otilia Tamara</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mukherjee A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jenny A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010519"><a href="/gui2/?type=authors&mode=browse&sel=10010519" target="_blank">Mihaly J ✉ (<span class="authorship-author-name">Mihály József</span> <span class="authorAux-mtmt"> genetika</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/<span title="Genetikai Intézet">GI</span>/MTA-SZBK-NAP B Axon növekedés és regeneráció kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2931297" target="_blank">The Formin DAAM Functions as Molecular Effector of the Planar Cell Polarity Pathway during Axonal Development in Drosophila</a></div> <div> <span class="journal-title">JOURNAL OF NEUROSCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0270-6474">0270-6474</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1529-2401">1529-2401</a>)</span>: <span class="journal-volume">35</span> <span class="journal-issue">28</span> <span class="page"> pp 10154-10167 </span> <span class="year">(2015)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span 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href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26180192&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 46</span> | Független: 36 | Függő: 10 | Nem jelölt: 0 | WoS jelölt: 44 | Scopus jelölt:&nbsp;39 | WoS/Scopus jelölt:&nbsp;45 | DOI jelölt:&nbsp;45 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2931297&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 2931297</span> | <span class="status-data status-APPROVED"> Nyilvános </span> <span class="oldId">Régi azonosító: 2931297</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="lastModified">Utolsó módosítás: 2025.04.02. 20:18 Pécsi Éva (MTMT Közp 2,3, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Institute of Genetics, Biological Research Centre HAS, Szeged, H-6726, Hungary Hungarian Academy of Sciences, Office for Subsidized Research Units, Budapest, H-1051, Hungary Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, 10461, NY, United States Export Date: 25 March 2025; Cit...</pre> </div></div>