https://m2.mtmt.hu/ hun 2026-04-29 21:14 JournalArticle 2924262 ADMIN_APPROVED true Funding Agency and Grant Number: Hungarian Scientific Research FundsOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [NK78012]; European UnionEuropean Commission; European Social FundEuropean Social Fund (ESF) [TAMOP 4.2.1./B-09/KMR-2010-0003]; Gedeon Richter Centenary Fund Funding text: The authors would like to thank Andre C. Dennes, Julie A. Brill, Suzanne Eaton, Jean-Paul Vincent and Thomas P. Neufeld for Drosophila stocks (listed in Table S1) and Rita Sinka for anti-Golgin antibody. T. M. thanks Gabriella Pasti and Viktor Billes for critical reading of the manuscript and Viktor Kis for helpful discussions. We also thank the two anonymous referees for their useful comments. This work was supported by a grant from the Hungarian Scientific Research Funds (NK78012) provided to M. S. The European Union and the European Social Fund have provided financial support to this project under the Grant agreement no. TAMOP 4.2.1./B-09/KMR-2010-0003. T. M. was partly supported by a predoctoral scholarship provided by the Gedeon Richter Centenary Fund. The authors declare that there is no conflict of interest regarding the publication of this article. 0 2018-10-02T08:54:25.000+0000 false 2924262 2026-04-02T13:22:21.409+0000 2022-04-12T07:33:06.347+0000 2015-07-30T15:59:16.000+0000 true 10000590 Juhász Gábor /api/author/10000590 Author true 10000590 2026-02-09T11:41:40.746+0000 2022-04-12T07:33:06.359+0000 true 10071503 Szabó Regina /api/admin/10071503 Admin true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10080085 /api/admin/10080085 Fölkerné Csernyik Rita true true 2024-10-17T16:48:31.101+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Maruzs, Tamás Retromer ensures the degradation of autophagic cargo via maintaining lysosome function in Drosophila. true true /api/journal/31945 REVIEWED true false 31945 false 31945 true 1398-9219 1600-0854 Journal FOREIGN 16 10 1088 1107 1088 20 2015 The retromer is an evolutionarily conserved coat complex that consists of Vps26, Vps29, Vps35 and a heterodimer of sorting nexin (Snx) protein in yeast. Retromer mediates the recycling of transmembrane proteins from endosomes to the trans-Golgi network, including receptors that are essential for the delivery of hydrolytic enzymes to lysosomes. Besides its function in lysosomal enzyme receptor recycling, involvement of retromer has also been proposed in a variety of vesicular trafficking events, including early steps of autophagy and endocytosis. Here we show that the late stages of autophagy and endocytosis are impaired in Vps26 and Vps35 deficient Drosophila larval fat body cells, but formation of autophagosomes and endosomes is not compromised. Accumulation of aberrant autolysosomes and amphisomes in the absence of retromer function appears to be the consequence of decreased degradative capacity, as they contain undigested cytoplasmic material. Accordingly, we show that retromer is required for proper cathepsin L trafficking mainly independent of LERP, the Drosophila homolog of the cation-independent mannose 6-phosphate receptor. Finally, we find that Snx3 and Snx6 are also required for proper autolysosomal degradation in Drosophila larval fat body cells. 2015 707614 true true true false true false RESTRICTED 2026-04-02 false 52 0 48 43 4 47 49 46 43 46 46 41 41 46 6 0 52 46 48 43 0 10 10 Folyóiratcikk Journal Article 24 47 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 4 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2015 0 1 1 1 1 2016 0 3 2 3 2 2017 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https://www.scopus.com/inward/record.uri?eid=2-s2.0-84941600807&doi=10.1111%2Ftra.12309&partnerID=40&md5=c65d7b36fb7bf1add893597355558f2e https://www.scopus.com/inward/record.uri?eid=2-s2.0-84941600807&doi=10.1111%2Ftra.12309&partnerID=40&md5=c65d7b36fb7bf1add893597355558f2e false true Classification 10545 /api/classification/10545 true true SjrRating 11007564 /api/sjrrating/11007564 28 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1303 /api/classificationexternal/1303 true 1303 true D1 DIRECT true true /api/publication/2924262 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10020437"><a href="/gui2/?type=authors&mode=browse&sel=10020437" target="_blank">Maruzs Tamás ✉ (<span class="authorship-author-name">Maruzs Tamás</span> <span class="authorAux-mtmt"> genetika</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet; <span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Anatómiai, Sejt- és Fejlődésbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020615"><a href="/gui2/?type=authors&mode=browse&sel=10020615" target="_blank">Lőrincz Péter (<span class="authorship-author-name">Lőrincz Péter</span> <span class="authorAux-mtmt"> Sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Anatómiai, Sejt- és Fejlődésbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020058"><a href="/gui2/?type=authors&mode=browse&sel=10020058" target="_blank">Szatmari Z (<span class="authorship-author-name">Szatmári Zsuzsanna</span> <span class="authorAux-mtmt"> biológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Anatómiai, Sejt- és Fejlődésbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Széplaki Szilvia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sándor Zoltán </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10062663"><a href="/gui2/?type=authors&mode=browse&sel=10062663" target="_blank">Lakatos Zsolt (<span class="authorship-author-name">Lakatos Zsolt</span> <span class="authorAux-mtmt"> Sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Anatómiai, Sejt- és Fejlődésbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10050179"><a href="/gui2/?type=authors&mode=browse&sel=10050179" target="_blank">Puska G (<span class="authorship-author-name">Puska Gina</span> <span class="authorAux-mtmt"> Idegtudomány, sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Anatómiai, Sejt- és Fejlődésbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000590"><a href="/gui2/?type=authors&mode=browse&sel=10000590" target="_blank">Juhasz Gábor (<span class="authorship-author-name">Juhász Gábor</span> <span class="authorAux-mtmt"> Sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Szegedi Biológiai Kutatóközpont">MTA SZBK</span>/Genetikai Intézet; <span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Anatómiai, Sejt- és Fejlődésbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009420"><a href="/gui2/?type=authors&mode=browse&sel=10009420" target="_blank">Sass M (<span class="authorship-author-name">Sass Miklós</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Anatómiai, Sejt- és Fejlődésbiológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2924262" target="_blank">Retromer ensures the degradation of autophagic cargo via maintaining lysosome function in Drosophila.</a></div> <div> <span class="journal-title">TRAFFIC</span> <span class="journal-issn">(<a target="_blank" 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Rita (MTMT ellenőrzés admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Hungarian Scientific Research FundsOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [NK78012]; European UnionEuropean Commission; European Social FundEuropean Social Fund (ESF) [TAMOP 4.2.1./B-09/KMR-2010-0003]; Gedeon Richter Centenary Fund Funding text: The authors would like to thank Andre C. Dennes, Julie A. Brill, Suzanne Eaton, Jean-Paul Vince...</pre> </div></div>