https://m2.mtmt.hu/ eng 2026-10-25 20:07 JournalArticle 2877855 APPROVED true Funding Agency and Grant Number: French Agence Nationale pour la Recherche (ANR); Fondation pour la Recherche Medicale (FRM) Funding text: This work was supported by the French Agence Nationale pour la Recherche (ANR). A.K. received a grant from the Fondation pour la Recherche Medicale (FRM). 0 2016-04-29T14:19:43.000+0000 false 2877855 2026-10-17T02:34:59.600+0000 2026-02-20T11:15:16.595+0000 2015-04-09T12:24:19.000+0000 true 10012926 Rózsa J. Balázs /api/author/10012926 Author true 10012926 2026-10-15T14:38:17.878+0000 2026-10-15T14:38:17.878+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Bouhadfane, M Sensitization of neonatal rat lumbar motoneuron by the inflammatory pain mediator bradykinin. true true /api/journal/10031024 REVIEWED true false 10031024 false 10031024 true 2050-084X Journal FOREIGN 4 e06195 e06195 51 2015 Bradykinin is a potent inflammatory mediator that causes hyperalgesia. The action of bradykinin on the sensory system is well documented but its effects on motoneurons, the final pathway of the motor system, are unknown. By a combination of patch-clamp recordings and two-photon calcium imaging, we found that bradykinin strongly sensitizes spinal motoneurons. Sensitization was characterized by an increased ability to generate self-sustained spiking in response to excitatory inputs. Our pharmacological study described a dual ionic mechanism to sensitize motoneurons, including inhibition of a barium-sensitive resting K+ conductance and activation of a nonselective cationic conductance primarily mediated by Na+. Examination of the upstream signaling pathways provided evidence for postsynaptic activation of B2 receptors, G protein activation of phospholipase C, InsP3 synthesis and calmodulin activation. This study questions the influence of motoneurons in the assessment of hyperalgesia since the withdrawal motor reflex is commonly used as a surrogate pain model. 2015 699456 true true true false true false GOLD 2026-10-17 true https://doi.org/10.7554/eLife.06195 14 0 12 9 0 11 11 8 8 9 9 6 6 10 4 0 14 10 12 9 0 2 2 Folyóiratcikk Journal Article 24 10 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 1 Egyéb Miscellaneous 29 1 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2016 0 2 2 2 2 2017 0 3 3 3 3 2018 0 1 1 1 1 2019 0 1 0 1 0 2020 0 4 2 4 2 2021 0 2 1 2 1 2022 0 1 1 1 1 D1 false false false false 2016-02-16T11:57:18.000+0000 2015-04-09T12:25:39.000+0000 Információs Technológiai és Bionikai Kar (PPKE); Két-foton Képalkotó Központ (KOKI / GYO) 2 25 2 6 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 6227891 /api/authorship/6227891 1 0.16666667 true false Bouhadfane M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 21469752 true PersonAuthorship 6227892 /api/authorship/6227892 2 0.16666667 false false Author 227 /api/author/227 Kaszás Attila true 227 true Kaszas A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 21469751 true PersonAuthorship 6227893 /api/authorship/6227893 3 0.16666667 false false Author 10012926 /api/author/10012926 Rózsa J. Balázs true 10012926 true Rozsa B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 21469750 true PersonAuthorship 6227894 /api/authorship/6227894 4 0.16666667 false false Harris-Warrick RM true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 21469749 true PersonAuthorship 6227895 /api/authorship/6227895 5 0.16666667 false false Vinay L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 21469748 true PersonAuthorship 6227896 /api/authorship/6227896 6 0.16666667 false true Brocard F true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 21469747 true PublicationIdentifier 969670 /api/publicationidentifier/969670 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.7554/eLife.06195 https://doi.org/10.7554/eLife.06195 false 1120297 true PublicationIdentifier 969668 /api/publicationidentifier/969668 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000351865600005 https://www.webofscience.com/wos/woscc/full-record/000351865600005 false 1166711 true PublicationIdentifier 969669 /api/publicationidentifier/969669 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84924973086 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84924973086 false 1219313 true PublicationIdentifier 969671 /api/publicationidentifier/969671 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 25781633 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25781633&dopt=Abstract false 1120298 true Classification 12125 /api/classification/12125 true true Classification 10545 /api/classification/10545 true true Classification 12548 /api/classification/12548 true true Classification 12215 /api/classification/12215 true true SjrRating 11037566 /api/sjrrating/11037566 20 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true D1 DIRECT true true /api/publication/2877855 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Bouhadfane M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="227"><a href="/gui2/?type=authors&mode=browse&sel=227" target="_blank">Kaszas A (<span class="authorship-author-name">Kaszás Attila</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012926"><a href="/gui2/?type=authors&mode=browse&sel=10012926" target="_blank">Rozsa B (<span class="authorship-author-name">Rózsa J. Balázs</span> <span class="authorAux-mtmt"> Idegtudomány, fizika</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Two-photon Imaging Center; <span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Harris-Warrick RM </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Vinay L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Brocard F </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2877855" target="_blank">Sensitization of neonatal rat lumbar motoneuron by the inflammatory pain mediator bradykinin.</a></div> <div> <span class="journal-title">ELIFE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2050-084X">2050-084X</a>)</span>: <span class="journal-volume">4</span> <span class="page"> Paper e06195. 51 p. </span> <span class="year">(2015)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.7554/eLife.06195" target="_blank" href="https://doi.org/10.7554/eLife.06195"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000351865600005" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000351865600005"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84924973086" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84924973086"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="25781633" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25781633&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Immunology and Microbiology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 14</span> | Independent citation: 10 | Self citation: 4 | Unknown citation: 0 | Number of citations in WoS: 8 | Number of citations in Scopus:&nbsp;8 | WoS/Scopus assigned:&nbsp;9 | Number of citations with DOI:&nbsp;11 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2877855&sort=publishedYear,desc&sort=title"> Number of cited publications: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2877855</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 2877855</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2026.02.20. 12:15 Attila Kaszás (Farmakológia) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: French Agence Nationale pour la Recherche (ANR); Fondation pour la Recherche Medicale (FRM) Funding text: This work was supported by the French Agence Nationale pour la Recherche (ANR). A.K. received a grant from the Fondation pour la Recherche Medicale (FRM).</pre> </div></div>