https://m2.mtmt.hu/ eng 2026-10-24 05:09 JournalArticle 2877847 APPROVED true Systems Neurobiology, Department II of Biology, Ludwig-Maximilians-Universität München, Martinsried, 82152, Germany Neurophysiology, Institute of Zoology, Universität Regensburg, Regensburg, 93040, Germany Computational Neuroscience, Department II of Biology, Ludwig-Maximilians-Universität München, Martinsried, 82152, Germany Two-Photon Imaging Center, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, 1039, Hungary Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, 1083, Hungary Cited By :38 Export Date: 30 January 2024 CODEN: NERNE Correspondence Address: Egger, V.; Neurophysiology, Germany; email: veronica.egger@ur.de Chemicals/CAS: Voltage-Gated Sodium Channel Agonists; Voltage-Gated Sodium Channels Funding details: Bundesministerium für Bildung und Forschung, BMBF, 01GQ1104, 01GQ1410A, DFG-SFB 870, DFG-SPP 1392, FP7-ICT-2011-C 323945 Funding details: Hungarian Scientific Research Fund, OTKA, K105997 Funding text 1: We thank V. Scheuss for advice on uncaging, H. Jacobi for technical assistance, B. Grothe for hosting the V.E. laboratory in Munich, and A. Schaefer and A. Roth for comments on the manuscript. This work was funded by the German Federal Ministry for Education and Research (BMBF, 01GQ1104, V.E.; 01GQ1410A, A.V.M.H.), DFG-SPP 1392 (Integrative Analysis of Olfaction; W.G.B., V.E.), with additional equipment funding by LMU-GSN and DFG-SFB 870. The development of DNI-Glu was supported by FP7-ICT-2011-C 323945 (3x3D imaging) and OTKA K105997 (B.R.). There are competing financial interests: B.R. is a founder of Femtonics Kft and a member of its scientific advisory board. 0 2018-02-23T09:21:56.000+0000 false 2877847 2026-10-17T02:35:25.068+0000 2024-05-02T08:52:53.900+0000 2015-04-09T12:20:02.000+0000 true 10012926 Rózsa J. Balázs /api/author/10012926 Author true 10012926 2025-03-22T18:51:28.006+0000 2025-03-22T18:51:28.006+0000 2015-09-29T10:10:55.000+0000 true 10019567 Sifter Viktória /api/admin/10019567 Admin true 10019567 2019-05-22T08:57:12.138+0000 true 10063747 Szepesi Dóra Anna /api/admin/10063747 Admin true 10063747 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Bywalez, WG Local postsynaptic voltage-gated sodium channel activation in dendritic spines of olfactory bulb granule cells. true true /api/journal/3357 REVIEWED true false 3357 false 3357 true 0896-6273 1097-4199 Journal FOREIGN 85 3 590 601 590 12 2015 Neuronal dendritic spines have been speculated to function as independent computational units, yet evidence for active electrical computation in spines is scarce. Here we show that strictly local voltage-gated sodium channel (Nav) activation can occur during excitatory postsynaptic potentials in the spines of olfactory bulb granule cells, which we mimic and detect via combined two-photon uncaging of glutamate and calcium imaging in conjunction with whole-cell recordings. We find that local Nav activation boosts calcium entry into spines through high-voltage-activated calcium channels and accelerates postsynaptic somatic depolarization, without affecting NMDA receptor-mediated signaling. Hence, Nav-mediated boosting promotes rapid output from the reciprocal granule cell spine onto the lateral mitral cell dendrite and thus can speed up recurrent inhibition. This striking example of electrical compartmentalization both adds to the understanding of olfactory network processing and broadens the general view of spine function. 2015 803490 true true true false true false NONE 2026-10-17 false true 10030885 Bálint Eszter /api/admin/10030885 Admin true 10030885 44 0 44 30 2 44 44 42 44 44 44 30 30 30 14 0 44 30 44 30 0 8 8 Folyóiratcikk Journal Article 24 44 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2015 0 4 3 4 3 2016 0 7 5 7 5 2017 0 7 6 7 6 2018 0 4 2 4 2 2019 0 3 1 3 1 2020 0 7 3 7 3 2021 0 2 1 2 1 2022 0 3 2 3 2 2023 0 2 2 2 2 2024 0 4 4 4 4 2025 0 1 1 1 1 D1 false false false false 2015-09-29T10:10:55.000+0000 2015-04-09T12:21:24.000+0000 Információs Technológiai és Bionikai Kar (PPKE); Két-foton Képalkotó Központ (KOKI / GYO); Multidiszciplináris Műszaki és Természettudomán... (PPKE / ITK) 2 16 3 8 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 6227877 /api/authorship/6227877 1 0.125 true false Bywalez WG true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 21469724 true PersonAuthorship 6227878 /api/authorship/6227878 2 0.125 false false Patirniche D true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 21469723 true PersonAuthorship 6227879 /api/authorship/6227879 3 0.125 false false Rupprecht V true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 21469722 true PersonAuthorship 6227880 /api/authorship/6227880 4 0.125 false false Stemmler M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 21469721 true PersonAuthorship 6227881 /api/authorship/6227881 5 0.125 false false Herz AV true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 21469720 true PersonAuthorship 6227882 /api/authorship/6227882 6 0.125 false false Author 10034709 /api/author/10034709 Pálfi Dénes true 10034709 true Palfi D true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 21469719 true PersonAuthorship 6227883 /api/authorship/6227883 7 0.125 false false Author 10012926 /api/author/10012926 Rózsa J. Balázs true 10012926 true Rozsa B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 21469718 true PersonAuthorship 6227884 /api/authorship/6227884 8 0.125 false true Egger V true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 21469717 true PublicationIdentifier 969662 /api/publicationidentifier/969662 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1016/j.neuron.2014.12.051 https://doi.org/10.1016/j.neuron.2014.12.051 false 1120287 true PublicationIdentifier 969660 /api/publicationidentifier/969660 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000349959700016 https://www.webofscience.com/wos/woscc/full-record/000349959700016 false 1166713 true PublicationIdentifier 969661 /api/publicationidentifier/969661 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84922122761 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84922122761 false 1727944 true PublicationIdentifier 969663 /api/publicationidentifier/969663 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 25619656 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25619656&dopt=Abstract false 1120288 true Classification 12125 /api/classification/12125 true true SjrRating 11042885 /api/sjrrating/11042885 4 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2801 /api/classificationexternal/2801 true 2801 true D1 DIRECT true true /api/publication/2877847 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Bywalez WG </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Patirniche D </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rupprecht V </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Stemmler M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Herz AV </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034709"><a href="/gui2/?type=authors&mode=browse&sel=10034709" target="_blank">Palfi D (<span class="authorship-author-name">Pálfi Dénes</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Catholic University">PPCU</span>/<span title="Információs Technológiai és Bionikai Kar">ITK</span>/Multidiszciplináris Műszaki és Természettudományi Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012926"><a href="/gui2/?type=authors&mode=browse&sel=10012926" target="_blank">Rozsa B (<span class="authorship-author-name">Rózsa J. Balázs</span> <span class="authorAux-mtmt"> Idegtudomány, fizika</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Two-photon Imaging Center; <span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Egger V </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2877847" target="_blank">Local postsynaptic voltage-gated sodium channel activation in dendritic spines of olfactory bulb granule cells.</a></div> <div> <span class="journal-title">NEURON</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0896-6273">0896-6273</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1097-4199">1097-4199</a>)</span>: <span class="journal-volume">85</span> <span class="journal-issue">3</span> <span class="page"> pp 590-601 </span> <span class="year">(2015)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.neuron.2014.12.051" target="_blank" href="https://doi.org/10.1016/j.neuron.2014.12.051"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000349959700016" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000349959700016"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84922122761" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84922122761"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="25619656" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25619656&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 44</span> | Independent citation: 30 | Self citation: 14 | Unknown citation: 0 | Number of citations in WoS: 42 | Number of citations in Scopus:&nbsp;44 | WoS/Scopus assigned:&nbsp;44 | Number of citations with DOI:&nbsp;44 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2877847&sort=publishedYear,desc&sort=title"> Number of cited publications: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2877847</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 2877847</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2024.05.02. 10:52 Viktória Sifter (PPKE ITK admin 5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Systems Neurobiology, Department II of Biology, Ludwig-Maximilians-Universität München, Martinsried, 82152, Germany Neurophysiology, Institute of Zoology, Universität Regensburg, Regensburg, 93040, Germany Computational Neuroscience, Department II of Biology, Ludwig-Maximilians-Universität München, Martinsried, 82152, Germany ...</pre> </div></div>