https://m2.mtmt.hu/ hun 2026-04-15 17:17 JournalArticle 2851040 VALIDATED true Department of Oto-Rhino-Laryngology, Jahn Ferenc South-Pest Hospital, 1st Köves Street, Budapest, 1204, Hungary Department of Oto-Rhino-Laryngology, Head-Neck Surgery, Semmelweis University, Budapest, Hungary MTA-SE Pathobiochemistry Research Group, Budapest, Hungary 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary MTA-SE Tumor Progression Research Group, Budapest, Hungary Cited By :23 Export Date: 2 June 2021 CODEN: POREF Correspondence Address: Szentkúti, G.; Department of Oto-Rhino-Laryngology, 1st Köves Street, Hungary Chemicals/CAS: epidermal growth factor receptor, 79079-06-4; Autoantigens; Biomarkers, Tumor; collagen type XVII; Cyclin-Dependent Kinase Inhibitor p16; EGFR protein, human; Ki-67 Antigen; Non-Fibrillar Collagens; Receptor, Epidermal Growth Factor; TP53 protein, human; Tumor Suppressor Protein p53 0 2018-10-02T08:54:25.000+0000 false 2851040 2025-12-23T23:31:59.242+0000 2021-08-25T09:11:58.925+0000 2015-01-05T22:39:25.000+0000 true 10010129 Tamás László /api/author/10010129 Author true 10010129 2025-03-04T11:43:08.414+0000 2016-02-04T13:02:27.000+0000 true 10030236 Molnár-Taga Márta /api/admin/10030236 Admin true 10030236 2021-03-30T13:58:09.715+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szentkuti, G Correlations Between Prognosis and Regional Biomarker Profiles in Head and Neck Squamous Cell Carcinomas true true /api/journal/1035680 REVIEWED true false 1035680 false 1035680 true 1219-4956 1532-2807 Journal FOREIGN_AND_HUNGARIAN 21 3 643 650 643 8 2015 Head and neck squamous cell carcinomas (HNSCC) show diverse clinicopathological features and are mostly linked with poor outcome. In this study, we tested if the expression of tumor growth, cell cycle and basement membrane anchorage related biomarkers allow prognostic and clinicopathological stratification of HNSCC. Archived HNSCC samples from 226 patients included into tissue microarrays (TMA) were tested using immunohistochemistry. Histopathological evaluation and the analysis of immunostaining for EGFR, Ki67, p53, p16ink4 and Collagen XVII proteins were carried out in digital whole slides. Statistical evaluation was carried out using Pearson's Chi-square test and Kaplan-Meier survival analysis. In the tested cohort, hypopharyngeal cancers had the least favorable, and glottic cancers had the most favorable prognosis. High Ki67 positive tumor cell fractions were associated with significantly worse prognosis and elevated rate of lymph node metastasis. Both Ki67 and EGFR expression correlated significantly with the tumor localization. Ki67 index was the highest in the hypopharyngeal region and it proved to be the lowest in the glottic region. EGFR expression was the highest in the oral cavity and the lowest in the glottic region. The survival rate of patients with p16ink4-negative cancer was significantly lower than of those with p16ink4-positive disease. A significant inverse correlation was found between histological grade and the prognosis of HNSCC. Our data support that elevated Ki67 positive proliferating cell fractions contribute to the unfavorable prognosis of hypopharyngeal cancers, while glottic cancers have the most favorable prognosis because of the lowest Ki67 expression rate. 2015 795899 true true true false true false CLOSED 2025-12-24 false 37 0 35 30 6 33 34 32 32 35 35 30 30 32 5 0 37 32 35 30 0 7 7 Folyóiratcikk Journal Article 24 34 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 2 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2015 0 4 4 4 4 2016 0 5 4 5 4 2017 0 8 8 8 8 2018 0 2 2 2 2 2019 0 5 5 5 5 2020 0 2 2 2 2 2021 0 2 2 2 2 2022 0 3 3 3 3 2023 0 3 1 3 1 2024 0 1 0 1 0 2025 0 2 1 2 1 Q2 false 10038518 false false false 2016-02-04T13:02:27.000+0000 2015-02-27T08:48:26.000+0000 Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika (SE / AOK / K); I. Sz. Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I); MTA-SE Molekuláris Onkológia Kutatócsoport (SE / AOK / I / IISZPI); MTA-SE Patobiokémiai Kutatócsoport (SE / AOK / I / BMBI / MBT) 7 22 4 8 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 6150896 /api/authorship/6150896 1 0.125 true false true Szentkuti G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 21331024 true PersonAuthorship 6150897 /api/authorship/6150897 2 0.125 false false Author 10038518 /api/author/10038518 Dános Kornél true 10038518 true Danos K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 21331023 true PersonAuthorship 6150898 /api/authorship/6150898 3 0.125 false false Author 10036137 /api/author/10036137 Brauswetter Diána true 10036137 true Brauswetter D true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 21331022 true PersonAuthorship 6150899 /api/authorship/6150899 4 0.125 false false Author 10032339 /api/author/10032339 Kiszner Gergő true 10032339 true Kiszner G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 21331021 true PersonAuthorship 6150900 /api/authorship/6150900 5 0.125 false false Author 10007878 /api/author/10007878 Krenács Tibor true 10007878 true Krenacs T true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 21331020 true PersonAuthorship 6150901 /api/authorship/6150901 6 0.125 false false Author 10054919 /api/author/10054919 Csákó László true 10054919 true Csako L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 21331019 true PersonAuthorship 6150902 /api/authorship/6150902 7 0.125 false false Author 10007417 /api/author/10007417 Répássy Gábor true 10007417 true Repassy G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 21331018 true PersonAuthorship 6150903 /api/authorship/6150903 8 0.125 false true Author 10010129 /api/author/10010129 Tamás László true 10010129 true Tamas L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 21331017 true PublicationIdentifier 957710 /api/publicationidentifier/957710 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1007/s12253-014-9869-4 https://doi.org/10.1007/s12253-014-9869-4 false 1081982 true PublicationIdentifier 957712 /api/publicationidentifier/957712 SwordSource 84 /api/publicationsource/84 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true SE Repozitórium SE Repozitórium https://repo.lib.semmelweis.hu/handle/123456789/@@@ true true 84 true CLOSED false IDENTICAL 2364 https://repo.lib.semmelweis.hu/handle/123456789/2364 false 1250498 true PublicationIdentifier 957708 /api/publicationidentifier/957708 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000355624700017 https://www.webofscience.com/wos/woscc/full-record/000355624700017 false 1180570 true PublicationIdentifier 957709 /api/publicationidentifier/957709 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84939416453 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84939416453 false 1226508 true PublicationIdentifier 957711 /api/publicationidentifier/957711 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 25547827 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25547827&dopt=Abstract false 1081983 true Classification 12125 /api/classification/12125 true true Classification 10545 /api/classification/10545 true true Classification 12548 /api/classification/12548 true true Classification 12215 /api/classification/12215 true true SjrRating 11038423 /api/sjrrating/11038423 823 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true Q2 DIRECT true true /api/publication/2851040 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Szentkuti G ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038518"><a href="/gui2/?type=authors&mode=browse&sel=10038518" target="_blank">Danos K (<span class="authorship-author-name">Dános Kornél</span> <span class="authorAux-mtmt"> Fül-Orr-Gégészet; Fej-Nyaksebészet, Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10036137"><a href="/gui2/?type=authors&mode=browse&sel=10036137" target="_blank">Brauswetter D (<span class="authorship-author-name">Brauswetter Diána</span> <span class="authorAux-mtmt"> patobiokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet">OVMBPI</span>/MTA-SE Patobiokémiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032339"><a href="/gui2/?type=authors&mode=browse&sel=10032339" target="_blank">Kiszner G (<span class="authorship-author-name">Kiszner Gergő</span> <span class="authorAux-mtmt"> Tumorbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/I. Sz. Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10007878"><a href="/gui2/?type=authors&mode=browse&sel=10007878" target="_blank">Krenacs T (<span class="authorship-author-name">Krenács Tibor</span> <span class="authorAux-mtmt"> Sejtbiológia, immunológia, pathológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/I. Sz. Patológiai és Kísérleti Rákkutató Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="II. Sz. Patológiai Intézet">IISZPI</span>/MTA-SE Molekuláris Onkológia Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054919"><a href="/gui2/?type=authors&mode=browse&sel=10054919" target="_blank">Csako L (<span class="authorship-author-name">Csákó László</span> <span class="authorAux-mtmt"> Fül-orr-gégészet</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10007417"><a href="/gui2/?type=authors&mode=browse&sel=10007417" target="_blank">Repassy G (<span class="authorship-author-name">Répássy Gábor</span> <span class="authorAux-mtmt"> Fül-orr-gégészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010129"><a href="/gui2/?type=authors&mode=browse&sel=10010129" target="_blank">Tamas L (<span class="authorship-author-name">Tamás László</span> <span class="authorAux-mtmt"> Fül-orr-gégészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2851040" target="_blank">Correlations Between Prognosis and Regional Biomarker Profiles in Head and Neck Squamous Cell Carcinomas</a></div> <div> <span class="journal-title">PATHOLOGY AND ONCOLOGY RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1219-4956">1219-4956</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1532-2807">1532-2807</a>)</span>: <span class="journal-volume">21</span> <span class="journal-issue">3</span> <span class="page"> pp 643-650 </span> <span class="year">(2015)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s12253-014-9869-4" target="_blank" href="https://doi.org/10.1007/s12253-014-9869-4"> DOI </a> </span> <span class="id identifier oa_CLOSED" title=" Zárt "> <a style="color:blue" title="2364" target="_blank" href="https://repo.lib.semmelweis.hu/handle/123456789/2364"> SE Repozitórium </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000355624700017" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000355624700017"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84939416453" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84939416453"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="25547827" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25547827&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pathology and Forensic Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 37</span> | Független: 32 | Függő: 5 | Nem jelölt: 0 | WoS jelölt: 32 | Scopus jelölt:&nbsp;32 | WoS/Scopus jelölt:&nbsp;35 | DOI jelölt:&nbsp;34 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2851040&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 2851040</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 2851040</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2021.08.25. 11:11 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Oto-Rhino-Laryngology, Jahn Ferenc South-Pest Hospital, 1st Köves Street, Budapest, 1204, Hungary Department of Oto-Rhino-Laryngology, Head-Neck Surgery, Semmelweis University, Budapest, Hungary MTA-SE Pathobiochemistry Research Group, Budapest, Hungary 1st Department of Pathology and Experimental Cancer Resea...</pre> </div></div>