Novel biocompatible polysaccharide-based self-healing hydrogel

Wei, Z; Yang, JH; Liu, ZQ; Xu, F; Zhou, JX; Zrínyi, M [Zrínyi, Miklós (Fizikai kémia, ko...), szerző] Biofizikai és Sugárbiológiai Intézet (SE / AOK / I); Osada, Y; Chen, YM

Angol nyelvű Szakcikk (Folyóiratcikk) Tudományos
Megjelent: ADVANCED FUNCTIONAL MATERIALS 1616-301X 1616-3028 25 (9) pp. 1352-1359 2015
  • SJR Scopus - Biomaterials: D1
  • Fizika
A novel biocompatible polysaccharide-based self-healing hydrogel, CEC-l-OSA-l-ADH hydrogel ("l" means "linked-by"), is developed by exploiting the dynamic reaction of N-carboxyethyl chitosan (CEC) and adipic acid dihydrazide (ADH) with oxidized sodium alginate (OSA). The self-healing ability, as demonstrated by rheological recovery, macroscopic observation, and beam-shaped strain compression measurement, is attributed to the coexistence of dynamic imine and acylhydrazone bonds in the hydrogel networks. The CEC-l-OSA-l-ADH hydrogel shows excellent self-healing ability under physiological conditions with a high healing efficiency (up to 95%) without need for any external stimuli. In addition, the CEC-l-OSA-l-ADH hydrogel exhibits good cytocompatibility and cell release as demonstrated by three-dimensional cell encapsulation. With these superior properties, the developed hydrogel holds great potential for applications in various biomedical fields, e.g., as cell or drug delivery carriers.
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2024-07-14 19:10