Peptides containing β-amino acid patterns: Challenges and successes in medicinal chemistry

Cabrele, C; Martinek, TA [Martinek, Tamás (Gyógyszerkémia), szerző] MTA-SZTE Lendület Peptidfoldamer Kutatócsoport (SZTE / GYTK / GYKI); Reiser, O; Berlicki, Ł ✉

Angol nyelvű Tudományos Összefoglaló cikk (Folyóiratcikk)
Megjelent: JOURNAL OF MEDICINAL CHEMISTRY 0022-2623 1520-4804 57 (23) pp. 9718-9739 2014
  • SJR Scopus - Drug Discovery: D1
    The construction of bioactive peptides using β-amino acid-containing sequence patterns is a very promising strategy to obtain analogues that exhibit properties of high interest for medicinal chemistry applications. β-Amino acids have been shown to modulate the conformation, dynamics, and proteolytic susceptibility of native peptides. They can be either combined with α-amino acids by following specific patterns, which results in backbone architectures with well-defined orientations of the side chain functional groups, or assembled in de novo-designed bioactive β- or α,β-peptidic sequences. Such peptides display various biological functions, including antimicrobial activity, inhibition of protein-protein interactions, agonism/antagonism of GPCR ligands, and anti-angiogenic activity.
    Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
    2021-04-13 22:41