https://m2.mtmt.hu/ hun 2026-10-23 04:04 JournalArticle 2808988 ADMIN_APPROVED true 0 2017-02-24T09:40:58.000+0000 false 2808988 2026-10-16T23:12:47.891+0000 2023-05-25T19:36:34.344+0000 2015-01-11T11:48:18.000+0000 true 10001301 Herszényi László /api/author/10001301 Author true 10001301 2023-05-25T12:42:46.404+0000 2023-05-25T12:42:46.404+0000 2023-05-25T19:36:34.820+0000 true 10065569 Pécsi Éva /api/admin/10065569 Admin true Admin 10065569 /api/admin/10065569 Pécsi Éva true true 2023-04-19T12:08:56.941+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Dignass, A Once versus three times daily dosing of oral budesonide for active Crohn's disease: a double-blind, double-dummy, randomised trial true true /api/journal/10009629 REVIEWED true false 10009629 false 10009629 true 1873-9946 1876-4479 Journal FOREIGN 8 9 970 980 970 11 2014 BACKGROUND: Oral budesonide 9 mg/day represents first-line treatment of mild-to-moderately active ileocolonic Crohn's disease. However, there is no precise recommendation for budesonide dosing due to lack of comparative data. A once-daily (OD) 9 mg dose may improve adherence and thereby efficacy. METHODS: An eight-week, double-blind, double-dummy randomised trial compared budesonide 9 mg OD versus 3mg three-times daily (TID) in patients with mild-to-moderately active ileocolonic Crohn's disease. Primary endpoint was clinical remission defined as CDAI <150 at week 8 (last observation carried forward). RESULTS: The final intent-to-treat population comprised 471 patients (238 [9 mg OD], 233 [3 mg TID]). The confirmatory population for the primary endpoint analysis was the interim per protocol population (n=377; 188 [9 mg OD], 189 [3mg TID]), in which the primary endpoint was statistically non-inferior with budesonide 9 mg OD versus 3 mg TID. Clinical remission was achieved in 71.3% versus 75.1%, a difference of -3.9% (95% CI [-14.6%; 6.4%]; p=0.020 for non-inferiority). The mean (SD) time to remission was 21.9 (13.8) days versus 21.4 (14.6) days with budesonide 9 mg OD versus 3 mg TID, respectively. In a subpopulation of 122 patients with baseline SES-CD ulcer score >/=1, complete mucosal healing occurred in 32.8% (21/64) on 9 mg OD and 41.4% (24/58) on 3mg TID; deep remission (mucosal healing and clinical remission) was observed in 26.6% (17/64) and 32.8% (19/58) of patients, respectively. Treatment-emergent suspected adverse drug reactions were reported in 4.6% of 9 mg OD and 4.7% of 3 mg TID patients. CONCLUSIONS: Budesonide at the recommended dose of 9 mg/day can be administered OD without impaired efficacy and safety compared to 3mg TID dosing in mild-to-moderately active Crohn's disease. 2015 (Herszényi László (Belgyógyászat, gasztroe...); 2015.01.11. 12:46:08) true true true false true false NONE 2026-10-17 false true 10045364 Fi Tamás /api/admin/10045364 Admin true 10045364 38 0 38 37 1 38 37 30 36 38 38 37 37 37 1 0 38 37 38 37 0 1 1 Folyóiratcikk Journal Article 24 37 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák 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false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20953483 true PersonAuthorship 5891835 /api/authorship/5891835 4 0.07692308 false false Grigorieva GA true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20953482 true PersonAuthorship 5891836 /api/authorship/5891836 5 0.07692308 false false Tomsova E true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20953481 true PersonAuthorship 5891837 /api/authorship/5891837 6 0.077 false false Author 10008259 /api/author/10008259 Altorjay István true 10008259 true Altorjay I true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20953480 true PersonAuthorship 5891838 /api/authorship/5891838 7 0.07692308 false false Tuculanu D true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20953479 true PersonAuthorship 5891839 /api/authorship/5891839 8 0.07692308 false false Bunganic I true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20953478 true PersonAuthorship 5891840 /api/authorship/5891840 9 0.07692308 false false Pokrotnieks J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20953477 true PersonAuthorship 5891841 /api/authorship/5891841 10 0.07692308 false false Kupcinskas L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20953476 true PersonAuthorship 5891842 /api/authorship/5891842 11 0.07692308 false false Dilger K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20953475 true PersonAuthorship 5891843 /api/authorship/5891843 12 0.07692308 false false Greinwald R true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20953474 true PersonAuthorship 5891844 /api/authorship/5891844 13 0.07692308 false true Mueller R true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20953473 true PersonAuthorship 5891846 /api/authorship/5891846 14 0.05882353 false false Author 1405456 /api/author/1405456 Tulassay Zsolt true 1405456 true Tulassay Z false false true AuthorshipType 12 /api/authorshiptype/12 -11 true -11 true false 20953665 true OrgAuthorship 5891845 /api/authorship/5891845 15 0.0 false false false true false false AuthorshipType 30 /api/authorshiptype/30 -29 true -29 true false 21401221 true PersonAuthorship 5891847 /api/authorship/5891847 15 0.05882353 false false Author 10001301 /api/author/10001301 Herszényi László true 10001301 true Herszényi L false false true AuthorshipType 12 /api/authorshiptype/12 -11 true -11 true false 20953664 true PersonAuthorship 5891848 /api/authorship/5891848 16 0.05882353 false false Author 10015656 /api/author/10015656 Juhász Márk true 10015656 true Juhász M false false true AuthorshipType 12 /api/authorshiptype/12 -11 true -11 true false 20953663 true PersonAuthorship 5891849 /api/authorship/5891849 17 0.05882353 false false Author 10015669 /api/author/10015669 Miheller Pál true 10015669 true Miheller P false false true AuthorshipType 12 /api/authorshiptype/12 -11 true -11 true false 20953662 true PersonAuthorship 5891850 /api/authorship/5891850 18 0.05882353 false false Author 10023605 /api/author/10023605 Mihály Emese true 10023605 true Mihály E false false true AuthorshipType 12 /api/authorshiptype/12 -11 true -11 true false 20953661 true PersonAuthorship 5891852 /api/authorship/5891852 19 0.05882353 false false Author 10039339 /api/author/10039339 Palatka Károly true 10039339 true Palatka K false false true AuthorshipType 12 /api/authorshiptype/12 -11 true -11 true false 20953659 true PersonAuthorship 5891853 /api/authorship/5891853 20 0.05882353 false false Kacska S false false true AuthorshipType 12 /api/authorshiptype/12 -11 true -11 true false 20953658 true PersonAuthorship 5891854 /api/authorship/5891854 21 0.05882353 false false Demeter P false false true AuthorshipType 12 /api/authorshiptype/12 -11 true -11 true false 20953657 true PersonAuthorship 5891855 /api/authorship/5891855 22 0.05882353 false false Penyige J false false true AuthorshipType 12 /api/authorshiptype/12 -11 true -11 true false 20953656 true PersonAuthorship 5891856 /api/authorship/5891856 23 0.05882353 false false Sike R false false true AuthorshipType 12 /api/authorshiptype/12 -11 true -11 true false 20953655 true PersonAuthorship 5891857 /api/authorship/5891857 24 0.05882353 false false Author 10048687 /api/author/10048687 Mester Gábor true 10048687 true Mester G false false true AuthorshipType 12 /api/authorshiptype/12 -11 true -11 true false 20953654 true PersonAuthorship 5891858 /api/authorship/5891858 25 0.05882353 false false Balogh M false false true AuthorshipType 12 /api/authorshiptype/12 -11 true -11 true false 20953653 true PersonAuthorship 5891859 /api/authorship/5891859 26 0.059 false false Author 10003584 /api/author/10003584 Rácz István true 10003584 true Rácz I false false true AuthorshipType 12 /api/authorshiptype/12 -11 true -11 true false 20953652 true PersonAuthorship 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24534142&dopt=Abstract false 1031384 true Classification 12548 /api/classification/12548 true true Classification 12215 /api/classification/12215 true true SjrRating 11092762 /api/sjrrating/11092762 241 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true D1 DIRECT true true /api/publication/2808988 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Dignass A ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Stoynov S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dorofeyev AE </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Grigorieva GA </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tomsova E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008259"><a href="/gui2/?type=authors&mode=browse&sel=10008259" target="_blank">Altorjay I (<span class="authorship-author-name">Altorjay István</span> <span class="authorAux-mtmt"> Belgyógyászat, gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Klinikai Központ">KK</span>/<span title="Belgyógyászati Klinika">BelgyKL</span>/B épület</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tuculanu D </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bunganic I </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pokrotnieks J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kupcinskas L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dilger K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Greinwald R </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mueller R </span> </div> <div class="autype autype-11"> Kollaborációs közreműködő: <span class="author-name" mtid="1405456"><a href="/gui2/?type=authors&mode=browse&sel=1405456" target="_blank">Tulassay Z (<span class="authorship-author-name">Tulassay Zsolt</span> <span class="authorAux-mtmt"> belgyógyászat, gastroenterologia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001301"><a href="/gui2/?type=authors&mode=browse&sel=10001301" target="_blank">Herszényi L (<span class="authorship-author-name">Herszényi László</span> <span class="authorAux-mtmt"> Belgyógyászat, gasztroenterológia, klinikai onk...</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015656"><a href="/gui2/?type=authors&mode=browse&sel=10015656" target="_blank">Juhász M (<span class="authorship-author-name">Juhász Márk</span> <span class="authorAux-mtmt"> belgyógyászat, gastroenterológia,molekuláris él...</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015669"><a href="/gui2/?type=authors&mode=browse&sel=10015669" target="_blank">Miheller P (<span class="authorship-author-name">Miheller Pál</span> <span class="authorAux-mtmt"> belgyógyászat, gasztroenterologia, molekuláris ...</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023605"><a href="/gui2/?type=authors&mode=browse&sel=10023605" target="_blank">Mihály E (<span class="authorship-author-name">Mihály Emese</span> <span class="authorAux-mtmt"> belgyógyászat, gastroenterologia, klinikai farm...</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10039339"><a href="/gui2/?type=authors&mode=browse&sel=10039339" target="_blank">Palatka K (<span class="authorship-author-name">Palatka Károly</span> <span class="authorAux-mtmt"> gastroenterológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kacska S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Demeter P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Penyige J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sike R </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048687"><a href="/gui2/?type=authors&mode=browse&sel=10048687" target="_blank">Mester G (<span class="authorship-author-name">Mester Gábor</span> <span class="authorAux-mtmt"> Belgyógyászat-Gasztroenterológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Balogh M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003584"><a href="/gui2/?type=authors&mode=browse&sel=10003584" target="_blank">Rácz I (<span class="authorship-author-name">Rácz István</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szabó A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Karasz T </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Csöndes M </span> </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">International Budenofalk Study Group</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2808988" target="_blank">Once versus three times daily dosing of oral budesonide for active Crohn's disease: a double-blind, double-dummy, randomised trial</a></div> <div> <span class="journal-title">JOURNAL OF CROHNS & COLITIS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1873-9946">1873-9946</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1876-4479">1876-4479</a>)</span>: <span class="journal-volume">8</span> <span class="journal-issue">9</span> <span class="page"> pp 970-980 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.crohns.2014.01.021" target="_blank" href="https://doi.org/10.1016/j.crohns.2014.01.021"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000342264900008" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000342264900008"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84906792062" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84906792062"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="24534142" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24534142&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Gastroenterology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 38</span> | Független: 37 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 30 | Scopus jelölt:&nbsp;36 | WoS/Scopus jelölt:&nbsp;38 | DOI jelölt:&nbsp;37 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2808988&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 2808988</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> <span class="oldId">Régi azonosító: 2808988</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2023.05.25. 21:36 Pécsi Éva (MTMT Közp 2,3, admin) </div> <div class="lockedBy">Központi kezelésű 2023.04.19. 14:08 Pécsi Éva (MTMT Közp 2,3, admin) </div> </div></div>