https://m2.mtmt.hu/ eng 2026-10-23 19:35 JournalArticle 2803475 VALIDATED true Funding Agency and Grant Number: Hungarian Academy of Sciences Lendulet [LP2012-23]; National Office for Research and Technology [OMFB-01678/2009]; European Research Council Advanced Grant [ERC-2011-ADG-294313 (SERRACO)] Funding text: This work was supported by a fellowship of the Hungarian Academy of Sciences Lendulet, LP2012-23 to N.H. and the National Office for Research and Technology OMFB-01678/2009. V.K.V. was supported by European Research Council Advanced Grant ERC-2011-ADG-294313 (SERRACO). We thank Peter Somogyi and Tamas F. Freund for their helpful comments on the manuscript; Hannah Monyer and Gabor Szabo for providing PV-EGFP mice; Karri Lamsa for advice with perforated patch recordings; Szabolcs Kali for help with analysis; Zsofia Huszar, Erzsebet Gregori and Eva Krizsan for excellent technical assistance; and Laszlo Barna, the Nikon Microscopy Center at the Institute of Experimental Medicine, Nikon Austria GmbH, and Auro-Science Consulting, Ltd, for providing microscopy support. 0 2018-06-07T09:13:48.000+0000 false 2803475 2026-10-16T22:46:24.718+0000 2026-01-27T08:48:02.820+0000 2015-01-06T07:25:29.000+0000 true 10018814 Veres Judit /api/author/10018814 Author true 10018814 2026-01-27T08:48:04.233+0000 2026-01-27T08:48:04.233+0000 2025-06-30T08:34:16.162+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Veres, JM Strategically Positioned Inhibitory Synapses of Axo-axonic Cells Potently Control Principal Neuron Spiking in the Basolateral Amygdala true true /api/journal/2707 REVIEWED true false 2707 false 2707 true 0270-6474 1529-2401 Journal FOREIGN 34 49 16194 16206 16194 13 2014 Axo-axonic cells (AACs) in cortical regions selectively innervate the axon initial segments (AISs) of principal cells (PCs), where the action potentials are generated. These GABAergic interneurons can alter the activity of PCs, but how the efficacy of spike control correlates with the number of output synapses remains unclear. Moreover, the relationship between the spatial distribution of GABAergic synapses and the action potential initiation site along the AISs is not well defined. Using paired recordings obtained in the mouse basolateral amygdala, we found that AACs powerfully inhibited or delayed the timing of PC spiking by 30 ms, if AAC output preceded PC spiking with no more than 80 ms. By correlating the number of synapses and the probability of spiking, we revealed that larger numbers of presynaptic AAC boutons giving rise to larger postsynaptic responses provided more effective inhibition of PC spiking. At least 10-12 AAC synapses, which could originate from 2-3 AACs on average, were necessary to veto the PC firing under our recording conditions. Furthermore, we determined that the threshold for the action potential generation along PC axons is the lowest between 20 and 40 mum from soma, which axonal segment received the highest density of GABAergic inputs. Single AACs preferentially innervated this narrow portion of the AIS where action potentials were generated with the highest likelihood, regardless of the number of synapses forming a given connection. Our results uncovered a fine organization of AAC innervation maximizing their inhibitory efficacy by strategically positioning synapses along the AISs. 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left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10018814"><a href="/gui2/?type=authors&mode=browse&sel=10018814" target="_blank">Veres JM (<span class="authorship-author-name">Veres Judit</span> <span class="authorAux-mtmt"> Idegélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of Ph. D. Studies; <span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Lendület Hálózat-Idegélettani Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061927"><a href="/gui2/?type=authors&mode=browse&sel=10061927" target="_blank">Nagy GA (<span class="authorship-author-name">Nagy Attila Gergő</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Lendület Hálózat-Idegélettani Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024264"><a href="/gui2/?type=authors&mode=browse&sel=10024264" target="_blank">Vereczki VK (<span class="authorship-author-name">Vereczki Viktória</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Lendület Hálózat-Idegélettani Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10039582"><a href="/gui2/?type=authors&mode=browse&sel=10039582" target="_blank">Andrási T (<span class="authorship-author-name">Andrási Tibor</span> <span class="authorAux-mtmt"> Elektrofiziológia</span>) </a> </span> <span class="author-affil">MTA Kísérleti Orvostudományi Kutatóintézet; <span title="Semmelweis University">SU</span>/School of Ph. D. Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010484"><a href="/gui2/?type=authors&mode=browse&sel=10010484" target="_blank">Hájos N ✉ (<span class="authorship-author-name">Hájos Norbert</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Lendület Hálózat-Idegélettani Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2803475" target="_blank">Strategically Positioned Inhibitory Synapses of Axo-axonic Cells Potently Control Principal Neuron Spiking in the Basolateral Amygdala</a></div> <div> <span class="journal-title">JOURNAL OF NEUROSCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0270-6474">0270-6474</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1529-2401">1529-2401</a>)</span>: <span class="journal-volume">34</span> <span class="journal-issue">49</span> <span class="page"> pp 16194-16206 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1523/JNEUROSCI.2232-14.2014" target="_blank" href="https://doi.org/10.1523/JNEUROSCI.2232-14.2014"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="20115" target="_blank" href="https://real.mtak.hu/20115"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000346147100004" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000346147100004"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84914689728" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84914689728"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="25471561" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25471561&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 63</span> | Independent citation: 53 | Self citation: 10 | Unknown citation: 0 | Number of citations in WoS: 62 | Number of citations in Scopus:&nbsp;58 | WoS/Scopus assigned:&nbsp;63 | Number of citations with DOI:&nbsp;63 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2803475&sort=publishedYear,desc&sort=title"> Number of cited publications: 20 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2803475</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 2803475</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="funder"> Momentum Programme of the Hungarian Academy of Sciences(Lendület, LP2012-23), Nemzeti Kutatási és Technológiai Hivatal(OMFB-01678/2009) </div> <div class="notDuplums"><a target="_blank" href="/api/publication/2803475/notduplums">1 marked as not duplum</a> </div> <div class="lastModified">Last Modified: 2026.01.27. 09:48 Tamás Pirmann (OOI admin4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: Hungarian Academy of Sciences Lendulet [LP2012-23]; National Office for Research and Technology [OMFB-01678/2009]; European Research Council Advanced Grant [ERC-2011-ADG-294313 (SERRACO)] Funding text: This work was supported by a fellowship of the Hungarian Academy of Sciences Lendulet, LP2012-23 to N.H. and the National Office for Research and Tech...</pre> </div></div>