https://m2.mtmt.hu/ eng 2026-10-25 20:45 JournalArticle 2792646 VALIDATED true Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, University of Gothenburg, Medicinaregatan 11, PO Box 434, Gothenburg, SE-405 30, Sweden Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Budapest, 1083, Hungary Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, SE-40530, Sweden Cambridge Institute for Medical Research, Medical Research Council, University of Cambridge, Cambridge, CB2 2XY, United Kingdom Cited By :75 Export Date: 28 January 2025 CODEN: ENDOA Correspondence Address: Skibicka, K.P.; Department of Physiology/Metabolic Physiology, Medicinaregatan 11, PO Box 434, Sweden Chemicals/CAS: calcitonin gene related peptide, 83652-28-2; exendin 4, 141732-76-5, 141758-74-9; glucagon like peptide 1, 89750-14-1; Glp1r protein, mouse; Glp1r protein, rat; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Receptors, Glucagon Funding details: WT084210/Z/07/Z, WT088357/Z/09/Z Funding details: Medical Research Council, MRC, MC_UU_12012/3 Funding details: Medical Research Council, MRC 0 2018-03-04T12:55:11.000+0000 false 2792646 2026-10-16T22:15:43.416+0000 2024-12-06T17:36:43.370+0000 2014-12-12T14:47:25.000+0000 true 10002755 Liposits Zsolt /api/author/10002755 Author true 10002755 2026-08-18T07:13:58.480+0000 2026-08-18T07:13:58.480+0000 2024-12-06T17:36:43.572+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Richard, JE GLP-1 receptor stimulation of the lateral parabrachial nucleus reduces food intake: neuroanatomical, electrophysiological, and behavioral evidence. true true /api/journal/1410 REVIEWED true false 1410 false 1410 true 0013-7227 1945-7170 Journal FOREIGN 155 11 4356 4367 4356 12 2014 The parabrachial nucleus (PBN) is a key nucleus for the regulation of feeding behavior. Inhibitory inputs from the hypothalamus to the PBN play a crucial role in the normal maintenance of feeding behavior, because their loss leads to starvation. Viscerosensory stimuli result in neuronal activation of the PBN. However, the origin and neurochemical identity of the excitatory neuronal input to the PBN remain largely unexplored. Here, we hypothesize that hindbrain glucagon-like peptide 1 (GLP-1) neurons provide excitatory inputs to the PBN, activation of which may lead to a reduction in feeding behavior. Our data, obtained from mice expressing the yellow fluorescent protein in GLP-1-producing neurons, revealed that hindbrain GLP-1-producing neurons project to the lateral PBN (lPBN). Stimulation of lPBN GLP-1 receptors (GLP-1Rs) reduced the intake of chow and palatable food and decreased body weight in rats. It also activated lPBN neurons, reflected by an increase in the number of c-Fos-positive cells in this region. Further support for an excitatory role of GLP-1 in the PBN is provided by electrophysiological studies showing a remarkable increase in firing of lPBN neurons after Exendin-4 application. We show that within the PBN, GLP-1R activation increased gene expression of 2 energy balance regulating peptides, calcitonin gene-related peptide (CGRP) and IL-6. Moreover, nearly 70% of the lPBN GLP-1 fibers innervated lPBN CGRP neurons. Direct intra-lPBN CGRP application resulted in anorexia. Collectively, our molecular, anatomical, electrophysiological, pharmacological, and behavioral data provide evidence for a functional role of the GLP-1R for feeding control in the PBN. Funding 1993733 /api/funding/1993733 false true Funding 1993734 /api/funding/1993734 false true true true 2014 780912 true true true false true false GREEN GREEN 2026-10-17 true https://real.mtak.hu/21472 true 10030885 Bálint Eszter /api/admin/10030885 Admin true 10030885 91 0 91 75 4 91 89 85 86 90 90 74 74 75 16 0 91 75 91 75 0 3 3 Folyóiratcikk Journal Article 24 87 Könyvrészlet Chapter in Book 25 3 Könyv Book 23 1 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2015 0 6 5 6 5 2016 0 9 6 9 6 2017 0 15 15 15 15 2018 0 7 7 7 7 2019 0 10 6 10 6 2020 0 7 6 7 6 2021 0 5 3 5 3 2022 0 6 4 6 4 2023 0 4 4 4 4 2024 0 5 4 5 4 2025 0 12 10 12 10 2026 0 5 5 5 5 D1 false false false false 2015-03-04T14:08:52.000+0000 2014-12-12T14:49:30.000+0000 Endokrin Neurobiológiai Kutatócsoport (KOKI / ENO) 2 16 1 10 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 5763674 /api/authorship/5763674 1 0.1 true false Richard JE true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20716085 true PersonAuthorship 5763675 /api/authorship/5763675 2 0.1 false false Author 10011497 /api/author/10011497 Farkas Imre true 10011497 true Farkas I true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20716084 true PersonAuthorship 5763676 /api/authorship/5763676 3 0.1 false false Anesten F true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20716083 true PersonAuthorship 5763677 /api/authorship/5763677 4 0.1 false false Anderberg RH true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20716082 true PersonAuthorship 5763678 /api/authorship/5763678 5 0.1 false false Dickson SL true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20716081 true PersonAuthorship 5763679 /api/authorship/5763679 6 0.1 false false Gribble FM true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20716080 true PersonAuthorship 5763680 /api/authorship/5763680 7 0.1 false false Reimann F true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20716079 true PersonAuthorship 5763681 /api/authorship/5763681 8 0.1 false false Jansson JO true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20716078 true PersonAuthorship 5763682 /api/authorship/5763682 9 0.1 false false Author 10002755 /api/author/10002755 Liposits Zsolt true 10002755 true Liposits Z true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20716077 true PersonAuthorship 5763683 /api/authorship/5763683 10 0.1 false true true Skibicka KP true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20716076 true PublicationIdentifier 923380 /api/publicationidentifier/923380 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1210/en.2014-1248 https://doi.org/10.1210/en.2014-1248 false 1014339 true PublicationIdentifier 923382 /api/publicationidentifier/923382 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GREEN true NO 21472 https://real.mtak.hu/21472 false 1069013 true PublicationIdentifier 923378 /api/publicationidentifier/923378 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000343422800025 https://www.webofscience.com/wos/woscc/full-record/000343422800025 false 1165842 true PublicationIdentifier 923379 /api/publicationidentifier/923379 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84908032915 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84908032915 false 1734089 true PublicationIdentifier 923381 /api/publicationidentifier/923381 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 25116706 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25116706&dopt=Abstract false 1014340 true Classification 12125 /api/classification/12125 true true Classification 10545 /api/classification/10545 true true Classification 12347 /api/classification/12347 true true Classification 12215 /api/classification/12215 true true Classification 12124 /api/classification/12124 true true SjrRating 11077254 /api/sjrrating/11077254 11 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1310 /api/classificationexternal/1310 true 1310 true D1 DIRECT true true /api/publication/2792646 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Richard JE </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011497"><a href="/gui2/?type=authors&mode=browse&sel=10011497" target="_blank">Farkas I (<span class="authorship-author-name">Farkas Imre</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Endocrine Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Anesten F </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Anderberg RH </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dickson SL </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gribble FM </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Reimann F </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jansson JO </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002755"><a href="/gui2/?type=authors&mode=browse&sel=10002755" target="_blank">Liposits Z (<span class="authorship-author-name">Liposits Zsolt</span> <span class="authorAux-mtmt"> Neurobiológia, neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Endocrine Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Skibicka KP ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2792646" target="_blank">GLP-1 receptor stimulation of the lateral parabrachial nucleus reduces food intake: neuroanatomical, electrophysiological, and behavioral evidence.</a></div> <div> <span class="journal-title">ENDOCRINOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0013-7227">0013-7227</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1945-7170">1945-7170</a>)</span>: <span class="journal-volume">155</span> <span class="journal-issue">11</span> <span class="page"> pp 4356-4367 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1210/en.2014-1248" target="_blank" href="https://doi.org/10.1210/en.2014-1248"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="21472" target="_blank" href="https://real.mtak.hu/21472"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000343422800025" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000343422800025"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84908032915" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84908032915"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="25116706" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25116706&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 91</span> | Independent citation: 75 | Self citation: 16 | Unknown citation: 0 | Number of citations in WoS: 85 | Number of citations in Scopus:&nbsp;86 | WoS/Scopus assigned:&nbsp;90 | Number of citations with DOI:&nbsp;89 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2792646&sort=publishedYear,desc&sort=title"> Number of cited publications: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2792646</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 2792646</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="funder"> Wellcome Trust(WT084210/Z/07/Z), Wellcome Trust(WT088357/Z/09/Z) </div> <div class="lastModified">Last Modified: 2024.12.06. 18:36 Róbert Milánkovics (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, University of Gothenburg, Medicinaregatan 11, PO Box 434, Gothenburg, SE-405 30, Sweden Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Budapest, 1083, Hungary Department of Physiology/Endocrinology, Institute of Neuroscience and Phys...</pre> </div></div>