https://m2.mtmt.hu/ hun 2026-09-23 01:38 JournalArticle 2789959 VALIDATED true Megjegyzés-24502089 CA PARADIGM-HF Investigators 0 2018-07-04T08:28:35.000+0000 false 2789959 2026-09-22T12:34:11.898+0000 2024-10-26T16:36:57.567+0000 2014-12-09T12:40:45.000+0000 true 10002691 Merkely Béla Péter /api/author/10002691 Author true 10002691 2025-01-31T18:49:28.319+0000 2025-01-31T18:49:28.319+0000 2022-11-24T21:09:46.235+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Packer, M Angiotensin Receptor Neprilysin Inhibition Compared With Enalapril on the Risk of Clinical Progression in Surviving Patients With Heart Failure. true true /api/journal/1023 REVIEWED true false 1023 false 1023 true 0009-7322 1524-4539 Journal FOREIGN 131 1 54 61 54 8 2015 BACKGROUND: -Clinical trials in heart failure have focused on the improvement in symptoms or decreases in the risk of death and other cardiovascular events. Little is known about the effect of drugs on the risk of clinical deterioration in surviving patients. METHODS AND RESULTS: -We compared the angiotensin-neprilysin inhibitor LCZ696 (400 mg daily) with the angiotensinconverting enzyme inhibitor enalapril (20 mg daily) in 8399 patients with heart failure and reduced ejection fraction in a double-blind trial. The analyses focused on prespecified measures of nonfatal clinical deterioration. In comparison with the enalapril group, fewer LCZ696-treated patients required intensification of medical treatment for heart failure (520 versus 604; hazard ratio, 0.84; 95% confidence interval, 0.74-0.94; P=0.003) or an emergency department visit for worsening heart failure (hazard ratio, 0.66; 95% confidence interval, 0.52-0.85; P=0.001). The patients in the LCZ696 group had 23% fewer hospitalizations for worsening heart failure (851 versus 1079; P<0.001) and were less likely to require intensive care (768 versus 879; 18% rate reduction, P=0.005), to receive intravenous positive inotropic agents (31% risk reduction, P<0.001), and to have implantation of a heart failure device or cardiac transplantation (22% risk reduction, P=0.07). The reduction in heart failure hospitalization with LCZ696 was evident within the first 30 days after randomization. Worsening of symptom scores in surviving patients was consistently more common in the enalapril group. LCZ696 led to an early and sustained reduction in biomarkers of myocardial wall stress and injury (N-terminal pro-Btype natriuretic peptide and troponin) versus enalapril. CONCLUSIONS: -Angiotensin-neprilysin inhibition prevents the clinical progression of surviving patients with heart failure more effectively than angiotensin-converting enzyme inhibition. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. 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Belgyógyászati Klinika és Kardiológiai ... 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Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Packer M ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely B (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; et al. (52) </div> <div class="autype autype-11"> Kollaborációs közreműködő: <span class="author-name" >Andrassy G </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10049457"><a href="/gui2/?type=authors&mode=browse&sel=10049457" target="_blank">Andreka P (<span class="authorship-author-name">Andréka Péter</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010124"><a href="/gui2/?type=authors&mode=browse&sel=10010124" target="_blank">Forster T (<span class="authorship-author-name">Forster Tamás</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/II. sz. Belgyógyászati Klinika és Kardiológiai Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032482"><a href="/gui2/?type=authors&mode=browse&sel=10032482" target="_blank">László Z (<span class="authorship-author-name">László Zoltán</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil">Szent János Kórház és Észak-budai Egyesített Kórházak</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely B (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015201"><a href="/gui2/?type=authors&mode=browse&sel=10015201" target="_blank">Nagy A (<span class="authorship-author-name">Nagy András</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054440"><a href="/gui2/?type=authors&mode=browse&sel=10054440" target="_blank">Nyolczas N (<span class="authorship-author-name">Nyolczas Noémi</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; et al. (31) </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">PARADIGM-HF Investigators and Coordinators</span> </div> <div><a target="_blank" href="/api/publication/2789959?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2789959" target="_blank">Angiotensin Receptor Neprilysin Inhibition Compared With Enalapril on the Risk of Clinical Progression in Surviving Patients With Heart Failure.</a></div> <div> <span class="journal-title">CIRCULATION</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0009-7322">0009-7322</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1524-4539">1524-4539</a>)</span>: <span class="journal-volume">131</span> <span class="journal-issue">1</span> <span class="page"> pp 54-61 </span> <span class="year">(2015)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1161/CIRCULATIONAHA.114.013748" target="_blank" href="https://doi.org/10.1161/CIRCULATIONAHA.114.013748"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000347299900017" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000347299900017"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84924243546" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84924243546"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="25403646" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25403646&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="24159" target="_blank" href="http://publicatio.bibl.u-szeged.hu/24159"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physiology (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 607</span> | Független: 517 | Függő: 90 | Nem jelölt: 0 | WoS jelölt: 547 | Scopus jelölt:&nbsp;554 | WoS/Scopus jelölt:&nbsp;590 | DOI jelölt:&nbsp;575 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2789959&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 2789959</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 2789959</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Utolsó módosítás: 2024.10.26. 18:36 Nagy András (Orvostudomány) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Megjegyzés-24502089 CA PARADIGM-HF Investigators</pre> </div></div>