https://m2.mtmt.hu/ eng 2026-10-24 07:56 JournalArticle 2772747 VALIDATED true Cited By :277 Export Date: 8 June 2023 CODEN: TPHSD Correspondence Address: Sperlágh, B.; Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary Chemicals/CAS: Purinergic P2X Receptor Antagonists; Receptors, Purinergic P2X7 Funding details: KTIA_13_NAP-A-III/1 Funding details: TÉT_10-1-2011-0050 Funding details: NN107234 Funding details: GZ 919 Funding details: Seventh Framework Programme, FP7, 294313 Funding details: European Research Council, ERC Funding details: Deutsche Forschungsgemeinschaft, DFG, IL 20/18-2, IL 20/21-1 Funding text 1: The authors are grateful to Ed Beamer for editing the manuscript. This work was supported by the Hungarian Research and Development Fund (grant number NN107234); Hungarian Office of Science and Technology (grant number TÉT_10-1-2011-0050), the Hungarian Brain Research Program [grant number KTIA_13_NAP-A-III/1], and the European Research Council [grant number 294313-SERRACO]. Further financial support was supplied by the Deutsche Forschungsgemeinschaft (IL 20/18-2; IL 20/21-1) and the Sino–German Centre for Research Promotion (GZ 919). 0 2016-07-18T07:45:07.000+0000 false 2772747 2026-10-19T05:51:52.597+0000 2023-02-03T08:28:09.555+0000 2014-11-13T10:14:21.000+0000 true 10008942 Sperlágh Beáta /api/author/10008942 Author true 10008942 2026-01-12T09:29:16.324+0000 2026-01-12T09:29:16.324+0000 2023-02-03T08:28:09.782+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 Admin 10066925 /api/admin/10066925 Nemec Évi true true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2024-10-17T16:20:19.023+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Sperlagh, B P2X7 receptor: an emerging target in central nervous system diseases. true true /api/journal/4322 REVIEWED true false 4322 false 4322 true 0165-6147 1873-3735 Journal FOREIGN 35 10 537 547 537 11 2014 The ATP-sensitive homomeric P2X7 receptor (P2X7R) has received particular attention as a potential drug target because of its widespread involvement in inflammatory diseases as a key regulatory element of the inflammasome complex. However, it has only recently become evident that P2X7Rs also play a pivotal role in central nervous system (CNS) pathology. There is an explosion of data indicating that genetic deletion and pharmacological blockade of P2X7Rs alter responsiveness in animal models of neurological disorders, such as stroke, neurotrauma, epilepsy, neuropathic pain, multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, and Huntington's disease. Moreover, recent studies suggest that P2X7Rs regulate the pathophysiology of psychiatric disorders, including mood disorders, implicating P2X7Rs as drug targets in a variety of CNS pathology. 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<span class="author-name" >Illes P </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2772747" target="_blank">P2X7 receptor: an emerging target in central nervous system diseases.</a></div> <div> <span class="journal-title">TRENDS IN PHARMACOLOGICAL SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0165-6147">0165-6147</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1873-3735">1873-3735</a>)</span>: <span class="journal-volume">35</span> <span class="journal-issue">10</span> <span class="page"> pp 537-547 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.tips.2014.08.002" target="_blank" href="https://doi.org/10.1016/j.tips.2014.08.002"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="18361" target="_blank" href="https://real.mtak.hu/18361"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000343353500006" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000343353500006"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84907899903" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84907899903"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="25223574" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25223574&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Toxicology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 354</span> | Independent citation: 304 | Self citation: 50 | Unknown citation: 0 | Number of citations in WoS: 337 | Number of citations in Scopus:&nbsp;343 | WoS/Scopus assigned:&nbsp;354 | Number of citations with DOI:&nbsp;351 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2772747&sort=publishedYear,desc&sort=title"> Number of cited publications: 14 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2772747</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 2772747</span> | Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="funder"> Hungarian Scientific Research Fund(NN107234), European Research Council(294313-SERRACO) </div> <div class="lastModified">Last Modified: 2023.02.03. 09:28 Rita Tichy (SE_KK_Admin5_TR, admin) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:20 Évi Nemec (MTMT Központi 3, admin) Gusztáv Ladányi (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Cited By :277 Export Date: 8 June 2023 CODEN: TPHSD Correspondence Address: Sperlágh, B.; Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of SciencesHungary Chemicals/CAS: Purinergic P2X Receptor Antagonists; Receptors, Purinergic P2X7 Funding...</pre> </div></div>