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Export Date: 5 December 2023
CODEN: JMNEE
Correspondence Address: Abad, C.; INSERM U1234 PANTHER, 22 Boulevard Gambetta, France; email: catalina.abad-rabat@univ-rouen.fr
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Immunomodulatory Roles of PACAP and VIP: Lessons from Knockout Mice
Lessons from Knockout Mice.
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A bidirectional cross-talk is established between the nervous and immune systems through common mediators including neuropeptides, neurotransmitters, and cytokines. Among these, PACAP and VIP are two highly related neuropeptides widely distributed in the organism with purported immunomodulatory actions. Due to their well-known anti-inflammatory properties, administration of these peptides has proven to be beneficial in models of acute and chronic inflammatory diseases. Nevertheless, the relevance of the endogenous source of these peptides in the modulation of immune responses remains to be elucidated. The development of transgenic mice with specific deletions in the genes coding for these neuropeptides (Vip and Adcyap1) or for their G-protein-coupled receptors VPAC1, VPAC2, and PAC1 (Vipr1, Vipr2, Adcyap1r1) has allowed to address this question, underscoring the complexity of the immunoregulatory properties of PACAP and VIP. The goal of this review is to integrate the existing information on the immune phenotypes of mice deficient for PACAP, VIP, or their receptors, to provide a global view on the roles of these endogenous neuropeptides during immunological health and disease.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Abad, Catalina </span> <span class="author-type"> </span> ; <span class="author-name" > Tan, Yossan-Var </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;27617488" mtid="27617488" target="_blank">Immunomodulatory Roles of PACAP and VIP: Lessons from Knockout Mice<span class="subTitle">: Lessons from Knockout Mice.</span></a></div> <div class="pub-info"> <span class="journal-title">JOURNAL OF MOLECULAR NEUROSCIENCE</span> <span class="journal-volume">66</span> : <span class="journal-issue">1</span> <span class="page"> pp. 102-113. , 12 p. </span> <span class="year">(2018)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s12031-018-1150-y" target="_blank" href="https://doi.org/10.1007/s12031-018-1150-y"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000445191700012" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000445191700012"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85051415019" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85051415019"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="30105629" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30105629&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:27617488 </span> <span class="status-holder"><span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span></span> <span class="pub-core"> Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> </div> </div> </div><div class="JournalArticle Publication long-list">
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<img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png">
<div class="autype autype0"> <span class="author-name" >Abad Catalina
</span>
;
<span class="author-name" >Tan Yossan-Var
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</div>
<div class="title"><a href="/gui2/?mode=browse¶ms=publication;27617488" target="_blank">Immunomodulatory Roles of PACAP and VIP: Lessons from Knockout Mice : Lessons from Knockout Mice..</a></div> <div> <span class="journal-title">JOURNAL OF MOLECULAR NEUROSCIENCE</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0895-8696">0895-8696</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1559-1166">1559-1166</a>)</span>:
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Idézett közlemények száma: 8
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<div class="mtid"><span class="long-pub-mtid">Közlemény: 27617488</span>
| <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott
</span>
<span class="oldId">Régi azonosító: 17617488</span> |
Idéző
| <span class="type-subtype">Folyóiratcikk
( Szakcikk
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<div class="notDuplums"><a target="_blank" href="/api/publication/27617488/notduplums">37 Nem duplumnak jelölés</a>
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<div class="lastModified">Utolsó módosítás: 2023.11.21. 22:29 Pécsi Éva (MTMT Közp 3, admin)
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<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Cited By :45
Export Date: 5 December 2023
CODEN: JMNEE
Correspondence Address: Abad, C.; INSERM U1234 PANTHER, 22 Boulevard Gambetta, France; email: catalina.abad-rabat@univ-rouen.fr</pre>
</div></div>