https://m2.mtmt.hu/ eng 2026-10-25 14:05 JournalArticle 2759425 VALIDATED true Department of Forensic Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 43 Szigony St., Budapest, HU-1083, Hungary Department of Neuroscience, Faculty of Information Technology, Pázmány Péter Catholic University, Budapest, Hungary INSERM U862, Neurocentre Magendie, Bordeaux, France Department of Investigative Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom Cited By :36 Export Date: 28 January 2025 CODEN: NUNDA Chemicals/CAS: gonadorelin, 33515-09-2, 9034-40-6; neurokinin B, 86933-75-7; substance P, 33507-63-0; Gonadotropin-Releasing Hormone; Kisspeptins; Neurokinin B; Substance P Funding details: K100722, K112669, K83710 Funding details: Medical Research Council, MRC, G1000455 Funding details: Medical Research Council, MRC 0 2017-06-08T10:06:06.000+0000 false 2759425 2026-10-16T20:33:19.444+0000 2026-06-17T06:15:39.292+0000 2014-10-20T09:24:58.000+0000 true 10019567 Sifter Viktória /api/admin/10019567 Admin true 10019567 2026-08-18T07:13:57.379+0000 2026-08-18T07:13:57.379+0000 2024-12-06T17:36:22.040+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Borsay, BA Hypophysiotropic Gonadotropin-Releasing Hormone Projections are Exposed to Dense Plexuses of Kisspeptin, Neurokinin B and Substance P Immunoreactive Fibers in the Human: A Study on Tissues from Postmenopausal Women. true true /api/journal/3350 REVIEWED true false 3350 false 3350 true 0028-3835 1423-0194 Journal FOREIGN 100 2-3 141 152 141 12 2014 Neuronal populations that synthesize kisspeptin (KP), neurokinin B (NKB) and substance P (SP) in the hypothalamic infundibular nucleus of humans are partly overlapping. These cells are important upstream regulators of gonadotropin-releasing hormone (GnRH) neurosecretion. Homologous neurons in laboratory animals are thought to modulate episodic GnRH secretion primarily via influencing KP receptors on the hypophysiotropic fiber projections of GnRH neurons. To explore the structural basis of this putative axo-axonal communication in humans, we analyzed the anatomical relationship of KP-immunoreactive (IR), NKB-IR and SP-IR axon plexuses with hypophysiotropic GnRH fiber projections. Immunohistochemical studies were carried out on histological samples from postmenopausal women. The neuropeptide-IR axons innervated densely the portal capillary network in the postinfundibular eminence. Subsets of the fibers formed descending tracts in the infundibular stalk, some reaching the neurohypophysis. KP-IR, NKB-IR and SP-IR plexuses intermingled, and established occasional contacts, with hypophysiotropic GnRH fibers in the postinfundibular eminence and through their lengthy course while descending within the infundibular stalk. Triple-immunofluorescent studies also revealed considerable overlap between the KP, NKB and SP signals in individual fibers, providing evidence that these peptidergic projections arise from neurons of the mediobasal hypothalamus. These neuroanatomical observations indicate that the hypophysiotropic projections of human GnRH neurons in the postinfundibular eminence and the descending GnRH tract coursing through the infundibular stalk to the neurohypophysis are exposed to neurotransmitters/neuropeptides released by dense KP-IR, NKB-IR and SP-IR fiber plexuses. Localization and characterization of axonal neuropeptide receptors will be required to clarify the putative autocrine and paracrine interactions in these anatomical regions. (c) 2014 S. Karger AG, Basel. 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/api/publication/2759425 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10036859"><a href="/gui2/?type=authors&mode=browse&sel=10036859" target="_blank">Borsay BA (<span class="authorship-author-name">Borsay Beáta Ágnes</span> <span class="authorAux-mtmt"> igazságügyi orvostan</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020450"><a href="/gui2/?type=authors&mode=browse&sel=10020450" target="_blank">Skrapits K (<span class="authorship-author-name">Skrapits Katalin</span> <span class="authorAux-mtmt"> neuroendokrinológia/reproduktív neurobiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10036799"><a href="/gui2/?type=authors&mode=browse&sel=10036799" target="_blank">Herczeg L (<span class="authorship-author-name">Herczeg László</span> <span class="authorAux-mtmt"> igazságügyi orvostan</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ciofi P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bloom SR </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ghatei MA </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dhillo WS </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002755"><a href="/gui2/?type=authors&mode=browse&sel=10002755" target="_blank">Liposits Z (<span class="authorship-author-name">Liposits Zsolt</span> <span class="authorAux-mtmt"> Neurobiológia, neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Endocrine Neurobiology; <span title="Pázmány Péter Catholic University">PPCU</span>/Faculty of Information Technology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011472"><a href="/gui2/?type=authors&mode=browse&sel=10011472" target="_blank">Hrabovszky E ✉ (<span class="authorship-author-name">Hrabovszky Erik</span> <span class="authorAux-mtmt"> Reproduktív endokrinológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Endocrine Neurobiology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2759425" target="_blank">Hypophysiotropic Gonadotropin-Releasing Hormone Projections are Exposed to Dense Plexuses of Kisspeptin, Neurokinin B and Substance P Immunoreactive Fibers in the Human: A Study on Tissues from Postmenopausal Women.</a></div> <div> <span class="journal-title">NEUROENDOCRINOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-3835">0028-3835</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1423-0194">1423-0194</a>)</span>: <span class="journal-volume">100</span> <span class="journal-issue">2-3</span> <span class="page"> pp 141-152 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1159/000368362" target="_blank" href="https://doi.org/10.1159/000368362"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="21481" target="_blank" href="https://real.mtak.hu/21481"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000348622800006" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000348622800006"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84922407254" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84922407254"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="25247878" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25247878&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://karger.com/article/doi/10.1159/000368362" target="_blank" href="https://karger.com/article/doi/10.1159/000368362"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Endocrine and Autonomic Systems&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Endocrinology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 36</span> | Independent citation: 25 | Self citation: 11 | Unknown citation: 0 | Number of citations in WoS: 32 | Number of citations in Scopus:&nbsp;36 | WoS/Scopus assigned:&nbsp;36 | Number of citations with DOI:&nbsp;35 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2759425&sort=publishedYear,desc&sort=title"> Number of cited publications: 15 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2759425</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 2759425</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="funder"> (K100722) Funder: HSRF, National Science Foundation(K112669), National Science Foundation(K83710) </div> <div class="lastModified">Last Modified: 2026.06.17. 08:15 Zsolt Heronyányi (PTE ÁOK admin 5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Forensic Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 43 Szigony St., Budapest, HU-1083, Hungary Department of Neuroscience, Faculty of Information Technology, Pázmány Péter Catholic University, Budapes...</pre> </div></div>