Simultaneous changes of spatial memory and spine density after intrahippocampal administration of fibrillar abeta1-42 to the rat brain.

Borbely, E [Borbély, Emőke (neurobiológia), author]; Horvath, J [Horváth, János (Neurobiológia), author]; Furdan, S [Furdan, Szabina (neurobiológia), author] MTA-SE NAP B Research Group for Cellular and Ne... (USZ / TTIK / BTCS / ÉSZIT); Bozso, Z [Bozsó, Zsolt (Peptid kémia), author] Department of Medical Chemistry (USZ / ÁOK); Penke, B [Penke, Botond (Neurodegeneráció,...), author] Department of Medical Chemistry (USZ / ÁOK); Fulop, L ✉ [Fülöp, Lívia (Neurodegeneratív ...), author] Department of Medical Chemistry (USZ / ÁOK)

English Scientific Article (Journal Article)
Published: BIOMED RESEARCH INTERNATIONAL 2314-6133 2314-6141 2014 Paper: 345305 , 9 p. 2014
  • SJR Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous): Q2
    Several animal models of Alzheimer's disease have been used in laboratory experiments. Intrahippocampal injection of fibrillar amyloid-beta (fAbeta) peptide represents one of the most frequently used models, mimicking Abeta deposits in the brain. In our experiment synthetic fAbeta1-42 peptide was administered to rat hippocampus. The effect of the Abeta peptide on spatial memory and dendritic spine density was studied. The fAbeta1-42-treated rats showed decreased spatial learning ability measured in Morris water maze (MWM). Simultaneously, fAbeta1-42 caused a significant reduction of the dendritic spine density in the rat hippocampus CA1 region. The decrease of learning ability and the loss of spine density were in good correlation. Our results prove that both methods (MWM and dendritic spine density measurement) are suitable for studying Abeta-triggered neurodegeneration processes.
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    2020-08-13 02:42