https://m2.mtmt.hu/ eng 2026-05-02 14:46 JournalArticle 2744859 VALIDATED true 0 2015-12-17T12:35:20.000+0000 false 2744859 2026-03-04T11:25:43.426+0000 2024-11-25T13:27:42.352+0000 2014-09-29T05:39:31.000+0000 true 10009548 Acsády László /api/author/10009548 Author true 10009548 2025-03-22T18:42:01.908+0000 2025-03-22T18:42:01.908+0000 2024-11-25T13:27:42.594+0000 true 10003134 Wolf György /api/admin/10003134 Admin true 10003134 Admin 10003134 /api/admin/10003134 Wolf György true 10003134 true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2024-10-17T16:42:14.442+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Matyas, F The fear circuit of the mouse forebrain: connections between the mediodorsal thalamus, frontal cortices and basolateral amygdala. true true /api/journal/1510 REVIEWED true false 1510 false 1510 true 0953-816X 1460-9568 Journal FOREIGN 39 11 1810 1823 1810 14 2014 A large forebrain circuit, including the thalamus, amygdala and frontal cortical regions, is responsible for the establishment and extinction of fear-related memories. Understanding interactions among these three regions is critical to deciphering the basic mechanisms of fear. With the advancement of molecular and optogenetics techniques, the mouse has become the main species used to study fear-related behaviours. However, the basic connectivity pattern of the forebrain circuits involved in processing fear has not been described in this species. In this study we mapped the connectivity between three key nodes of the circuit, i.e. the basolateral nucleus of the amygdala (BLA), the mediodorsal nucleus of the thalamus (MD) and the medial prefrontal cortex, which were shown to have closed triangular connectivity in rats. In contrast to rat, we found no evidence for this closed loop in mouse. There was no major input from the BLA to the MD and little overlap between medial prefrontal regions connected with both the BLA and MD. The common nodes in the frontal cortex, which displayed reciprocal connection with both the BLA and MD were the agranular insular cortex and the border zone of the cingulate and secondary motor cortex. In addition, the BLA can indirectly affect the MD via the orbital cortex. We attribute the difference between our results and earlier rat studies to methodological problems rather than to genuine species difference. Our data demonstrate that the BLA and MD communicate via cortical sectors, the roles in fear-related behaviour of which have not been extensively studied. In general, our study provides the morphological framework for studies of murine fear-related behaviours. 2014 659392 true true true false true false GREEN GREEN 2026-03-04 true http://real.mtak.hu/22018 74 0 74 67 4 74 73 72 73 74 74 67 67 67 7 0 74 67 74 67 0 4 4 Folyóiratcikk Journal Article 24 71 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 1 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2015 0 5 5 5 5 2016 0 3 3 3 3 2017 0 9 9 9 9 2018 0 12 12 12 12 2019 0 10 8 10 8 2020 0 10 9 10 9 2021 0 12 12 12 12 2022 0 4 2 4 2 2023 0 4 3 4 3 2024 0 2 2 2 2 2025 0 3 2 3 2 Q1 false 163 false false false 2015-10-26T13:29:56.000+0000 2014-09-29T05:41:16.000+0000 Thalamus Kutatócsoport (HRN KOKI) 2 22 1 4 0 true 10003134 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 5493269 /api/authorship/5493269 1 0.25 true false Author 163 /api/author/163 Mátyás Ferenc true 163 true Matyas F true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20308370 true PersonAuthorship 5493270 /api/authorship/5493270 2 0.25 false false Lee J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20308369 true PersonAuthorship 5493271 /api/authorship/5493271 3 0.25 false false Shin HS true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20308368 true PersonAuthorship 5493272 /api/authorship/5493272 4 0.25 false true Author 10009548 /api/author/10009548 Acsády László true 10009548 true Acsady L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20308367 true PublicationIdentifier 895853 /api/publicationidentifier/895853 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true PAY false IDENTICAL 10.1111/ejn.12610 https://doi.org/10.1111/ejn.12610 false 959646 true PublicationIdentifier 895855 /api/publicationidentifier/895855 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL http://real.mtak.hu/@@@ true true 36 true GREEN true NO 22018 http://real.mtak.hu/22018 false 1078687 true PublicationIdentifier 895851 /api/publicationidentifier/895851 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000337540800010 https://www.webofscience.com/wos/woscc/full-record/000337540800010 false 1165839 true PublicationIdentifier 895852 /api/publicationidentifier/895852 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84901659753 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84901659753 false 1233951 true PublicationIdentifier 895854 /api/publicationidentifier/895854 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false NO 24819022 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24819022&dopt=Abstract false 959647 true Classification 12125 /api/classification/12125 true true SjrRating 11097849 /api/sjrrating/11097849 27 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2801 /api/classificationexternal/2801 true 2801 true Q1 DIRECT true true /api/publication/2744859 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="163"><a href="/gui2/?type=authors&mode=browse&sel=163" target="_blank">Matyas F (<span class="authorship-author-name">Mátyás Ferenc</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Thalamus Research</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lee J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Shin HS </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009548"><a href="/gui2/?type=authors&mode=browse&sel=10009548" target="_blank">Acsady L (<span class="authorship-author-name">Acsády László</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Thalamus Research</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2744859" target="_blank">The fear circuit of the mouse forebrain: connections between the mediodorsal thalamus, frontal cortices and basolateral amygdala.</a></div> <div> <span class="journal-title">EUROPEAN JOURNAL OF NEUROSCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0953-816X">0953-816X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1460-9568">1460-9568</a>)</span>: <span class="journal-volume">39</span> <span class="journal-issue">11</span> <span class="page"> pp 1810-1823 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Pay "> <a style="color:blue" title="10.1111/ejn.12610" target="_blank" href="https://doi.org/10.1111/ejn.12610"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="22018" target="_blank" href="http://real.mtak.hu/22018"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000337540800010" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000337540800010"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84901659753" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84901659753"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="24819022" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24819022&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 74</span> | Independent citation: 67 | Self citation: 7 | Unknown citation: 0 | Number of citations in WoS: 72 | Number of citations in Scopus:&nbsp;73 | WoS/Scopus assigned:&nbsp;74 | Number of citations with DOI:&nbsp;73 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2744859&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2744859</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 2744859</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2024.11.25. 14:27 György Wolf (MTMT Központi admin) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:42 György Wolf (MTMT Központi admin) Gusztáv Ladányi (MTMT API user, admin) </div> </div></div>