https://m2.mtmt.hu/ eng 2026-10-24 20:46 JournalArticle 2741026 APPROVED true 0 2017-05-25T06:23:06.000+0000 false 2741026 2026-10-16T19:32:05.502+0000 2022-12-03T15:41:34.722+0000 2014-09-24T16:41:55.000+0000 true 10006860 Madarász Emilia /api/author/10006860 Author true 10006860 2025-03-24T08:01:00.963+0000 2025-03-24T08:01:00.963+0000 2015-01-30T09:28:19.000+0000 true 10039736 xRadó Nikolett /api/admin/10039736 Admin true 10039736 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Hegyi, B Regulation of Mouse Microglia Activation and Effector Functions by Bone Marrow-Derived Mesenchymal Stem Cells. true true /api/journal/10001383 REVIEWED true false 10001383 false 10001383 true 1547-3287 1557-8534 Journal FOREIGN 23 21 2600 2612 2600 13 2014 Mesenchymal stems or stromal cells (MSCs) are rare multipotent cells with potent regenerative and immunomodulatory properties. Microglial cells (MGs) are specialized tissue macrophages of the central nervous system (CNS) that continuously survey their environment with highly motile extensions. Recently, several studies have shown that MSCs are capable of reprogramming microglia into an "M2-like" phenotype characterized by increased phagocytic activity and upregulated expression of anti-inflammatory mediators in vitro. However, the precise polarization states of microglia in the presence of MSCs under physiological or under inflammatory conditions remain largely unknown. In this study, we found that MSCs induce a mixed microglia phenotype defined as Arg1-high, CD86-high, CD206-high, IL-10-high, PGE2-high, MCP-1/CCL2-high, IL-1beta-moderate, NALP-3-low, and TNF-alpha-low cells. These MSC-elicited MGs have high phagocytic activity and antigen-presenting ability. Lipopolysaccharide is able to shape this microglia phenotype quantitatively, but not qualitatively in the presence of MSCs. 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ClassificationExternal 2720 /api/classificationexternal/2720 true 2720 true Q1 DIRECT true true /api/publication/2741026 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Hegyi B </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011503"><a href="/gui2/?type=authors&mode=browse&sel=10011503" target="_blank">Kornyei Z (<span class="authorship-author-name">Környei Zsuzsanna</span> <span class="authorAux-mtmt"> Neuroimmunológia; Idegi sejt- és fejlődésbiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Gene Technology and Developmental Neurobiology">DGTDN</span>/Laboratory of Neural Cell Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013609"><a href="/gui2/?type=authors&mode=browse&sel=10013609" target="_blank">Ferenczi S (<span class="authorship-author-name">Ferenczi Szilamér</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Molecular Neuroendocrinology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10049451"><a href="/gui2/?type=authors&mode=browse&sel=10049451" target="_blank">Fekete R (<span class="authorship-author-name">Fekete Rebeka</span> <span class="authorAux-mtmt"> idegtudomány</span>) </a> </span> <span class="author-affil">MTA Kísérleti Orvostudományi Kutatóintézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043361"><a href="/gui2/?type=authors&mode=browse&sel=10043361" target="_blank">Kudlik G (<span class="authorship-author-name">Kudlik Gyöngyi</span> <span class="authorAux-mtmt"> molekuláris sejtbiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009124"><a href="/gui2/?type=authors&mode=browse&sel=10009124" target="_blank">Kovacs KJ (<span class="authorship-author-name">Kovács Krisztina</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Molecular Neuroendocrinology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10006860"><a href="/gui2/?type=authors&mode=browse&sel=10006860" target="_blank">Madarasz E (<span class="authorship-author-name">Madarász Emilia</span> <span class="authorAux-mtmt"> Idegi sejtbiológia, sejtdifferenciáció</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Gene Technology and Developmental Neurobiology">DGTDN</span>/Laboratory of Neural Cell Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10004551"><a href="/gui2/?type=authors&mode=browse&sel=10004551" target="_blank">Uher F (<span class="authorship-author-name">Uher Ferenc</span> <span class="authorAux-mtmt"> Őssejtbiológia, immunológia</span>) </a> </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2741026" target="_blank">Regulation of Mouse Microglia Activation and Effector Functions by Bone Marrow-Derived Mesenchymal Stem Cells.</a></div> <div> <span class="journal-title">STEM CELLS AND DEVELOPMENT</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1547-3287">1547-3287</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1557-8534">1557-8534</a>)</span>: <span class="journal-volume">23</span> <span class="journal-issue">21</span> <span class="page"> pp 2600-2612 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Pay "> <a style="color:blue" title="10.1089/scd.2014.0088" target="_blank" href="https://doi.org/10.1089/scd.2014.0088"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="13139" target="_blank" href="https://real.mtak.hu/13139"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000343602900006" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000343602900006"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84913612974" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84913612974"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="24870815" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24870815&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="http://DOI 10.1089/scd.2014.0088" target="_blank" href="http://DOI 10.1089/scd.2014.0088"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Hematology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Developmental Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 42</span> | Independent citation: 39 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 39 | Number of citations in Scopus:&nbsp;39 | WoS/Scopus assigned:&nbsp;41 | Number of citations with DOI:&nbsp;42 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2741026&sort=publishedYear,desc&sort=title"> Number of cited publications: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2741026</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 2741026</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2022.12.03. 16:41 Márta Turek (KOKI admin 4) </div> </div></div>