https://m2.mtmt.hu/ eng 2026-10-24 17:03 JournalArticle 2739699 APPROVED true Cited By :35 Export Date: 6 April 2023 CODEN: EJONE Correspondence Address: Nusser, Z.; Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony Street 43, Budapest, Hungary; email: nusser@koki.hu Chemicals/CAS: G Protein-Coupled Inwardly-Rectifying Potassium Channels; Kv1.1 Potassium Channel; Shab Potassium Channels Funding details: Seventh Framework Programme, FP7, 293681 0 2017-08-21T08:37:41.000+0000 false 2739699 2026-10-16T19:29:48.280+0000 2022-12-03T19:59:25.904+0000 2014-09-23T15:19:57.000+0000 true 10000499 Nusser Zoltán /api/author/10000499 Author true 10000499 2025-03-24T11:31:36.243+0000 2025-03-24T11:31:36.243+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kirizs, T Distinct axo-somato-dendritic distributions of three potassium channels in CA1 hippocampal pyramidal cells. true true /api/journal/1510 REVIEWED true false 1510 false 1510 true 0953-816X 1460-9568 Journal FOREIGN 39 11 1771 1783 1771 13 2014 Potassium channels comprise the most diverse family of ion channels and play critical roles in a large variety of physiological and pathological processes. In addition to their molecular diversity, variations in their distributions and densities on the axo-somato-dendritic surface of neurons are key parameters in determining their functional impact. Despite extensive electrophysiological and anatomical investigations, the exact location and densities of most K(+) channels in small subcellular compartments are still unknown. Here we aimed at providing a quantitative surface map of two delayed-rectifier (Kv1.1 and Kv2.1) and one G-protein-gated inwardly rectifying (Kir3.2) K(+) channel subunits on hippocampal CA1 pyramidal cells (PCs). Freeze-fracture replica immunogold labelling was employed to determine the relative densities of these K(+) channel subunits in 18 axo-somato-dendritic compartments. Significant densities of the Kv1.1 subunit were detected on axon initial segments (AISs) and axon terminals, with an approximately eight-fold lower density in the latter compartment. The Kv2.1 subunit was found in somatic, proximal dendritic and AIS plasma membranes at approximately the same densities. This subunit has a non-uniform plasma membrane distribution; Kv2.1 clusters are frequently adjacent to, but never overlap with, GABAergic synapses. A quasi-linear increase in the Kir3.2 subunit density along the dendrites of PCs was detected, showing no significant difference between apical dendritic shafts, oblique dendrites or dendritic spines at the same distance from the soma. Our results demonstrate that each subunit has a unique cell-surface distribution pattern, and predict their differential involvement in synaptic integration and output generation at distinct subcellular compartments. true true 2014 803179 true true true false true false GOLD 2026-10-16 true https://doi.org/10.1111/ejn.12526 true 10039736 xRadó Nikolett /api/admin/10039736 Admin true 10039736 42 0 42 38 4 41 42 41 41 42 42 38 38 38 4 0 42 38 42 38 0 6 6 Folyóiratcikk Journal Article 24 39 Könyvrészlet Chapter in Book 25 3 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2014 0 1 1 1 1 2015 0 5 4 5 4 2016 0 7 6 7 6 2017 0 7 6 7 6 2018 0 4 4 4 4 2019 0 3 2 3 2 2020 0 1 1 1 1 2021 0 2 2 2 2 2022 0 4 4 4 4 2023 0 1 1 1 1 2024 0 3 3 3 3 2025 0 3 3 3 3 2026 0 1 1 1 1 Q1 false false false false 2015-02-01T13:48:56.000+0000 2014-11-03T13:48:56.000+0000 Celluláris Idegélettani Kutatócsoport (HRN KOKI) 4 13 1 4 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 5484560 /api/authorship/5484560 1 0.25 true false Author 10055040 /api/author/10055040 Kirizs Tekla true 10055040 true Kirizs T true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20289482 true PersonAuthorship 5484561 /api/authorship/5484561 2 0.25 false false Author 210 /api/author/210 Kerti-Szigeti Katalin true 210 true Kerti-Szigeti K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20289481 true PersonAuthorship 5484562 /api/authorship/5484562 3 0.25 false false Author 10012931 /api/author/10012931 Lőrincz Andrea true 10012931 true Lorincz A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20289480 true PersonAuthorship 5484563 /api/authorship/5484563 4 0.25 false true true Author 10000499 /api/author/10000499 Nusser Zoltán true 10000499 true Nusser Z true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20289479 true PublicationIdentifier 893021 /api/publicationidentifier/893021 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1111/ejn.12526 https://doi.org/10.1111/ejn.12526 false 954601 true PublicationIdentifier 893019 /api/publicationidentifier/893019 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000337540800007 https://www.webofscience.com/wos/woscc/full-record/000337540800007 false 1165832 true PublicationIdentifier 893020 /api/publicationidentifier/893020 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84901696881 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84901696881 false 1622102 true PublicationIdentifier 893022 /api/publicationidentifier/893022 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false NO 24606584 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24606584&dopt=Abstract false 954602 true Classification 12125 /api/classification/12125 true true SjrRating 11097849 /api/sjrrating/11097849 27 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2801 /api/classificationexternal/2801 true 2801 true Q1 DIRECT true true /api/publication/2739699 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10055040"><a href="/gui2/?type=authors&mode=browse&sel=10055040" target="_blank">Kirizs T (<span class="authorship-author-name">Kirizs Tekla</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="210"><a href="/gui2/?type=authors&mode=browse&sel=210" target="_blank">Kerti-Szigeti K (<span class="authorship-author-name">Kerti-Szigeti Katalin</span> <span class="authorAux-mtmt"> Celluláris idegélettan</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012931"><a href="/gui2/?type=authors&mode=browse&sel=10012931" target="_blank">Lorincz A (<span class="authorship-author-name">Lőrincz Andrea</span> <span class="authorAux-mtmt"> Neuroanatómia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000499"><a href="/gui2/?type=authors&mode=browse&sel=10000499" target="_blank">Nusser Z ✉ (<span class="authorship-author-name">Nusser Zoltán</span> <span class="authorAux-mtmt"> Celluláris idegélettan</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cellular Neurophysiology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2739699" target="_blank">Distinct axo-somato-dendritic distributions of three potassium channels in CA1 hippocampal pyramidal cells.</a></div> <div> <span class="journal-title">EUROPEAN JOURNAL OF NEUROSCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0953-816X">0953-816X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1460-9568">1460-9568</a>)</span>: <span class="journal-volume">39</span> <span class="journal-issue">11</span> <span class="page"> pp 1771-1783 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1111/ejn.12526" target="_blank" href="https://doi.org/10.1111/ejn.12526"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000337540800007" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000337540800007"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84901696881" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84901696881"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="24606584" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24606584&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 42</span> | Independent citation: 38 | Self citation: 4 | Unknown citation: 0 | Number of citations in WoS: 41 | Number of citations in Scopus:&nbsp;41 | WoS/Scopus assigned:&nbsp;42 | Number of citations with DOI:&nbsp;42 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2739699&sort=publishedYear,desc&sort=title"> Number of cited publications: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2739699</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 2739699</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2022.12.03. 20:59 Márta Turek (KOKI admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Cited By :35 Export Date: 6 April 2023 CODEN: EJONE Correspondence Address: Nusser, Z.; Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony Street 43, Budapest, Hungary; email: nusser@koki.hu Chemicals/CAS: G Protein-Coupled Inwardly-Rect...</pre> </div></div>