https://m2.mtmt.hu/ eng 2026-10-23 00:55 JournalArticle 2739698 APPROVED true Department of Neuroscience, Physiology and Pharmacology, University College London, London, WC1E 6BT, United Kingdom Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Cited By :94 Export Date: 13 June 2024 CODEN: NERNE Correspondence Address: Silver, R.A.; Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary; email: a.silver@ucl.ac.uk Funding details: Wellcome Trust, WT, 086699 Funding details: Seventh Framework Programme, FP7, 293681, 294667 Funding details: Biotechnology and Biological Sciences Research Council, BBSRC, F005490 Funding details: European Commission, EC, 238686, FP7-ITN-PEOPLE-2008, WT094513 Funding details: European Research Council, ERC, 095667 Funding details: Magyar Tudományos Akadémia, MTA, LP2012-29 Funding text 1: Support was provided to R.A.S. from the BBSRC (F005490), Wellcome Trust (086699), and his ERC Advanced Grant (294667) and Wellcome Trust Principal Research Fellowship (095667); to E.P. from the EU Marie Curie Initial Training Network CEREBNET (FP7-ITN-PEOPLE-2008; 238686); to Z.N. from the Wellcome Trust (WT094513), a Lendület Grant from the Hungarian Academy of Sciences (LP2012-29), and his ERC Advanced Grant; and to A.L. from a Janos Bolyai Scholarship of the Hungarian Academy of Sciences. We thank Laszlo Kocsis for help with analyzing glomeruli volume and D. Attwell, P. Dayan, M. van Rossum, C. Houghton, J. Rothman, A. Valera, and B. Marin for comments on the manuscript. We acknowledge use of the UCL Computer Science Cluster and Legion HPC Facility (Legion@UCL) and support services. 0 2017-08-21T08:32:23.000+0000 false 2739698 2026-10-16T19:29:39.855+0000 2024-01-04T10:44:29.175+0000 2014-09-23T15:19:54.000+0000 true 10000499 Nusser Zoltán /api/author/10000499 Author true 10000499 2025-03-17T08:33:19.569+0000 2025-03-17T08:33:19.569+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Billings, G Network Structure within the Cerebellar Input Layer Enables Lossless Sparse Encoding. true true /api/journal/3357 REVIEWED true false 3357 false 3357 true 0896-6273 1097-4199 Journal FOREIGN 83 4 960 974 960 15 2014 The synaptic connectivity within neuronal networks is thought to determine the information processing they perform, yet network structure-function relationships remain poorly understood. By combining quantitative anatomy of the cerebellar input layer and information theoretic analysis of network models, we investigated how synaptic connectivity affects information transmission and processing. Simplified binary models revealed that the synaptic connectivity within feedforward networks determines the trade-off between information transmission and sparse encoding. Networks with few synaptic connections per neuron and network-activity-dependent threshold were optimal for lossless sparse encoding over the widest range of input activities. Biologically detailed spiking network models with experimentally constrained synaptic conductances and inhibition confirmed our analytical predictions. Our results establish that the synaptic connectivity within the cerebellar input layer enables efficient lossless sparse encoding. Moreover, they provide a functional explanation for why granule cells have approximately four dendrites, a feature that has been evolutionarily conserved since the appearance of fish. 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<span class="author-name" >Piasini E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012931"><a href="/gui2/?type=authors&mode=browse&sel=10012931" target="_blank">Lorincz A (<span class="authorship-author-name">Lőrincz Andrea</span> <span class="authorAux-mtmt"> Neuroanatómia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000499"><a href="/gui2/?type=authors&mode=browse&sel=10000499" target="_blank">Nusser Z (<span class="authorship-author-name">Nusser Zoltán</span> <span class="authorAux-mtmt"> Celluláris idegélettan</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Silver RA ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2739698" target="_blank">Network Structure within the Cerebellar Input Layer Enables Lossless Sparse Encoding.</a></div> <div> <span class="journal-title">NEURON</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0896-6273">0896-6273</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1097-4199">1097-4199</a>)</span>: <span class="journal-volume">83</span> <span class="journal-issue">4</span> <span class="page"> pp 960-974 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1016/j.neuron.2014.07.020" target="_blank" href="https://doi.org/10.1016/j.neuron.2014.07.020"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000340479600021" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000340479600021"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84907598845" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84907598845"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="25123311" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25123311&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 112</span> | Independent citation: 102 | Self citation: 10 | Unknown citation: 0 | Number of citations in WoS: 103 | Number of citations in Scopus:&nbsp;105 | WoS/Scopus assigned:&nbsp;112 | Number of citations with DOI:&nbsp;111 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2739698&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2739698</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 2739698</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="funder"> European Commission(FP7-ITN-PEOPLE-2008), Wellcome Trust(086699) </div> <div class="lastModified">Last Modified: 2024.01.04. 11:44 Márta Turek (KOKI admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Neuroscience, Physiology and Pharmacology, University College London, London, WC1E 6BT, United Kingdom Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Cited By :94 Export Date: 13 June 2024 CODEN: NERNE Correspondence A...</pre> </div></div>