https://m2.mtmt.hu/ eng 2026-10-23 19:36 JournalArticle 2739695 APPROVED true Inhibitory Transmission Team, IBENS, CNRS UMR UMR8197, INSERM U1024, Ecole Normale Supérieure, Paris, 75005, France Cerebellum Group, IBENS, CNRS UMR UMR8197, INSERM U1024, Ecole Normale Supérieure, Paris, 75005, France Institut des Neurosciences Cellulaires et Intégratives, CNRS UPR 3212, Strasbourg, 67000, France Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine of the Hungarian Academy of Sciences, Budapest, 1083, Hungary Imaging Facility, IBENS, CNRS UMR 8197, INSERM U1024, Ecole Normale Supérieure, Paris, 75005, France Department of Neurophysiology, Graduate School of Medicine, University of Tokyo, Tokyo, 113-0033, Japan Center for Transdisciplinary Research, Niigata University, Niigata, 950-2181, Japan Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata, 951-8585, Japan Cited By :41 Export Date: 11 April 2023 CODEN: NERNE Correspondence Address: Dieudonné, S.; Inhibitory Transmission Team, France Chemicals/CAS: Kv Channel-Interacting Proteins Funding details: 21220006, 21300118, 25000015 Funding details: Wellcome Trust, WT, ANR-10-LABX-54 MEMO LIFE, ANR-11-IDEX-001-02-PSL, WT094513 Funding details: Seventh Framework Programme, FP7, 293681 Funding details: European Research Council, ERC Funding details: Human Frontier Science Program, HFSP, P60/2003 Funding details: Agence Nationale de la Recherche, ANR, 06-BLAN-0178, 11-BSV4-010 INNET Funding details: Institut National de la Santé et de la Recherche Médicale, Inserm Funding details: Ministry of Education, Culture, Sports, Science and Technology, MEXT Funding details: Centre National de la Recherche Scientifique, CNRS Funding details: Fédération pour la Recherche sur le Cerveau, FRC Funding text 1: We thank T. Schneider and J. Hescheler (CMMC, University of Cologne) for providing the Cav2.3 KO mouse line. We are grateful to B. Barbour for comments on the manuscript. This work was supported by CNRS, INSERM, French Ministère de la Recherche, French Agence Nationale de la Recherche (06-BLAN-0178; 11-BSV4-010 INNET), HFSP (P60/2003), and FRC/Rotary (Espoir en Tête 2010). The work was also supported partly by Grants-in-Aid for Scientific Research (21220006 and 25000015 to M.K., 21300118 to K.S.) and Strategic Research Program for Brain Sciences (project D) from the Ministry of Education, Culture, Sports, Science and Technology, Japan. Y.O. received fellowships from FRM and Région Ile de France. The work of Z.N. is supported by a European Research Council Advanced Grant and a Wellcome Trust Project Grant (WT094513). This work has received support under the program Investissements d’Avenir from the French Government and implemented by the ANR (ANR-10-LABX-54 MEMO LIFE, ANR-11-IDEX-001-02-PSL) to IBENS. 0 2017-08-21T08:41:42.000+0000 false 2739695 2026-10-16T19:29:29.207+0000 2023-04-05T08:27:28.177+0000 2014-09-23T15:19:44.000+0000 true 10000499 Nusser Zoltán /api/author/10000499 Author true 10000499 2025-03-24T11:31:36.068+0000 2025-03-24T11:31:36.068+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Otsu, Y Activity-Dependent Gating of Calcium Spikes by A-type K+ Channels Controls Climbing Fiber Signaling in Purkinje Cell Dendrites. true true /api/journal/3357 REVIEWED true false 3357 false 3357 true 0896-6273 1097-4199 Journal FOREIGN 84 1 137 151 137 15 2014 In cerebellar Purkinje cell dendrites, heterosynaptic calcium signaling induced by the proximal climbing fiber (CF) input controls plasticity at distal parallel fiber (PF) synapses. The substrate and regulation of this long-range dendritic calcium signaling are poorly understood. Using high-speed calcium imaging, we examine the role of active dendritic conductances. Under basal conditions, CF stimulation evokes T-type calcium signaling displaying sharp proximodistal decrement. Combined mGluR1 receptor activation and depolarization, two activity-dependent signals, unlock P/Q calcium spikes initiation and propagation, mediating efficient CF signaling at distal sites. These spikes are initiated in proximal smooth dendrites, independently from somatic sodium action potentials, and evoke high-frequency bursts of all-or-none fast-rising calcium transients in PF spines. Gradual calcium spike burst unlocking arises from increasing inactivation of mGluR1-modulated low-threshold A-type potassium channels located in distal dendrites. Evidence for graded activity-dependent CF calcium signaling at PF synapses refines current views on cerebellar supervised learning rules. 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4 0.09090909 false false Isope P true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20289454 true PersonAuthorship 5484545 /api/authorship/5484545 5 0.09090909 false false Kollo M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20289453 true PersonAuthorship 5484546 /api/authorship/5484546 6 0.09090909 false false Author 10000499 /api/author/10000499 Nusser Zoltán true 10000499 true Nusser Z true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20289452 true PersonAuthorship 5484547 /api/authorship/5484547 7 0.09090909 false false Mathieu B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20289451 true PersonAuthorship 5484548 /api/authorship/5484548 8 0.09090909 false false Kano M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20289450 true PersonAuthorship 5484549 /api/authorship/5484549 9 0.09090909 false false Tsujita M true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20289449 true PersonAuthorship 5484550 /api/authorship/5484550 10 0.09090909 false false Sakimura K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20289448 true PersonAuthorship 5484551 /api/authorship/5484551 11 0.091 false true true Dieudonne S true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20289447 true PublicationIdentifier 893011 /api/publicationidentifier/893011 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD false IDENTICAL 10.1016/j.neuron.2014.08.035 https://doi.org/10.1016/j.neuron.2014.08.035 false 954589 true PublicationIdentifier 893009 /api/publicationidentifier/893009 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 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/api/classification/12125 true true SjrRating 11097826 /api/sjrrating/11097826 4 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2801 /api/classificationexternal/2801 true 2801 true D1 DIRECT true true /api/publication/2739695 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Otsu Y </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Marcaggi P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Feltz A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Isope P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kollo M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000499"><a href="/gui2/?type=authors&mode=browse&sel=10000499" target="_blank">Nusser Z (<span class="authorship-author-name">Nusser Zoltán</span> <span class="authorAux-mtmt"> Celluláris idegélettan</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mathieu B </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kano M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tsujita M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sakimura K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dieudonne S ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2739695" target="_blank">Activity-Dependent Gating of Calcium Spikes by A-type K+ Channels Controls Climbing Fiber Signaling in Purkinje Cell Dendrites.</a></div> <div> <span class="journal-title">NEURON</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0896-6273">0896-6273</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1097-4199">1097-4199</a>)</span>: <span class="journal-volume">84</span> <span class="journal-issue">1</span> <span class="page"> pp 137-151 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1016/j.neuron.2014.08.035" target="_blank" href="https://doi.org/10.1016/j.neuron.2014.08.035"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000342502800016" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000342502800016"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84907994501" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84907994501"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="25220810" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25220810&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 55</span> | Independent citation: 44 | Self citation: 11 | Unknown citation: 0 | Number of citations in WoS: 51 | Number of citations in Scopus:&nbsp;52 | WoS/Scopus assigned:&nbsp;55 | Number of citations with DOI:&nbsp;55 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2739695&sort=publishedYear,desc&sort=title"> Number of cited publications: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2739695</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 2739695</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="funder"> Wellcome Trust(ANR-10-LABX-54 MEMO LIFE), Human Frontier Science Program(P60/2003) </div> <div class="lastModified">Last Modified: 2023.04.05. 10:27 Márta Turek (KOKI admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Inhibitory Transmission Team, IBENS, CNRS UMR UMR8197, INSERM U1024, Ecole Normale Supérieure, Paris, 75005, France Cerebellum Group, IBENS, CNRS UMR UMR8197, INSERM U1024, Ecole Normale Supérieure, Paris, 75005, France Institut des Neurosciences Cellulaires et Intégratives, CNRS UPR 3212, Strasbourg, 67000, France Laborato...</pre> </div></div>