PACAP and its receptors in cranial arteries and mast cells

Jansen-Olesen, Inger; Hougaard, Pedersen Sara

Angol nyelvű Tudományos Összefoglaló cikk (Folyóiratcikk)
Megjelent: JOURNAL OF HEADACHE AND PAIN 1129-2369 1129-2377 19 (1) Paper: 16 , 11 p. 2018
  • SJR Scopus - Anesthesiology and Pain Medicine: Q1
Azonosítók
Szakterületek:
    Background: In migraineurs pituitary adenylate cyclase activating peptide1-38 (PACAP1-38) is a potent migraine provoking substance and the accompanying long lasting flushing suggests degranulation of mast cells. Infusion of the closely related vasoactive intestinal peptide (VIP) either induces headache or flushing. This implicates the pituitary adenylate cyclase activating peptide type I receptor (PAC1) to be involved in the pathophysiology of PACAP1-38 provoked headaches. Here we review studies characterizing the effects of mainly PACAP but also of VIP on cerebral and meningeal arteries and mast cells.
    Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSLMásolásNyomtatás
    2020-09-27 13:19