Concentrated Ambient PM2.5-Induced Inflammation and Endothelial Dysfunction in a Murine Model of Neural IKK2 Deficiency

Chen, Minjie; Qin, Xiaobo; Qiu, Lianglin; Chen, Sufang; Zhou, Huifen; Xu, Yanyi; Hu, Ziying; Zhang, Yuhao; Cao, Qi; Ying, Zhekang

Angol nyelvű Tudományos Szakcikk (Folyóiratcikk)
Megjelent: ENVIRONMENTAL HEALTH PERSPECTIVES 0091-6765 126 (2) Paper: UNSP 027003 , 10 p. 2018
  • SJR Scopus - Health, Toxicology and Mutagenesis: D1
    BACKGROUND: Exposure to ambient fine particulate matter (PM2.5) is associated with cardiovascular mortality, but underlying pathophysiologic mechanisms are not fully understood. Hypothalamic inflammation, characterized by the activation of Inhibitor kappaB kinase 2/Nuclear factor kappaB (IKK2/NF-kappa B) signaling pathway, may play an important role in the pathogenesis of cardiovascular diseases. We recently demonstrated that hypothalamic inflammation is increased in mice exposed to concentrated ambient PM2.5 (CAP).
    Hivatkozás stílusok: IEEEACMAPAChicagoHarvardCSL
    2020-03-28 10:47