https://m2.mtmt.hu/ eng 2026-10-24 17:03 JournalArticle 2729280 VALIDATED true Cited By :31 Export Date: 8 June 2023 CODEN: JHPOA Correspondence Address: Sperlágh, B.; Laboratory of Molecular Pharmacology, Budapest, Szigony u., 43, Hungary; email: sperlagh@koki.hu Chemicals/CAS: glyceryl trinitrate, 55-63-0, 80738-44-9 Funding details: TÉT_10-1-2011-0050 Funding details: NN107234 Funding details: Seventh Framework Programme, FP7, 294313 Funding details: European Research Council, ERC Funding text 1: The authors are grateful to Ágnes Kittel and Rómeó D. Andó in their help in setting up the experimental procedures, for Ed Beamer for editing the manuscript and for Bence Koványi for technical assistance. This work was supported by the Hungarian Research and Development Fund [grant number NN107234]; Hungarian Office of Science and Technology [grant number TÉT_10-1-2011-0050] and the European Research Council [grant number 294313-SERRACO]. 0 2018-03-01T07:59:02.000+0000 false 2729280 2026-10-16T18:58:31.814+0000 2023-02-02T14:05:03.773+0000 2014-09-09T11:04:26.000+0000 true 10008942 Sperlágh Beáta /api/author/10008942 Author true 10008942 2026-01-12T09:29:15.303+0000 2026-01-12T09:29:15.303+0000 2023-02-02T14:05:04.070+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 Admin 10066925 /api/admin/10066925 Nemec Évi true true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true 2024-10-17T16:20:19.023+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Goloncser, F Effect of genetic deletion and pharmacological antagonism of P2X7 receptors in a mouse animal model of migraine true true /api/journal/10009637 REVIEWED true false 10009637 false 10009637 true 1129-2369 1129-2377 Journal FOREIGN 15 24 24 8 2014 BACKGROUND: Purine receptors participate in peripheral and central sensitization and are associated with migraine headache. We investigated the role of P2X7 receptor (P2X7) in a nitroglycerin (NTG)-induced mouse model of migraine. METHODS: Intraperitoneal NTG injection (15 mg/kg) triggered thermal hyperalgesia in the hindpaws of wild-type C57BL/6J mice, followed by the induction of c-fos in upper cervical spinal cord and trigeminal nucleus caudalis. The effect of genetic deletion of P2X7 and the selective P2X7 antagonist Brilliant Blue G (BBG) were examined on hyperalgesia and c-fos induction. RESULTS: NTG decreased the paw withdrawal threshold in both wild-type and P2X7 knockout mice. Nevertheless, subacute BBG treatment (50 mg/kg/day i.p.) completely prevented the effect of NTG in wild-type, but not in knockout mice. Whereas P2X7 deficiency differentially affected the expression of c-fos, the average number of fos-immuno-reactive neurons in trigeminal nucleus caudalis, but not in upper cervical spinal cord was lower in BBG-treated wild-type mice after NTG treatment. CONCLUSIONS: Our results show that P2X7 receptors might participate in the pathogenesis of migraine, although upregulation of other P2X receptors probably compensate for the loss of its action in knockout mice. The data also suggest the therapeutic potential of P2X7 antagonists for the treatment of migraine. true true 2014 725102 true true true false true false GOLD 2026-10-16 true https://doi.org/10.1186/1129-2377-15-24 true 10030885 Bálint Eszter /api/admin/10030885 Admin true 10030885 39 0 39 37 4 37 39 37 37 39 39 37 37 37 2 0 39 37 39 37 0 8 8 Folyóiratcikk Journal Article 24 37 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2014 0 1 0 1 0 2015 0 2 2 2 2 2016 0 4 4 4 4 2017 0 5 5 5 5 2018 0 4 4 4 4 2019 0 3 3 3 3 2020 0 3 3 3 3 2021 0 7 6 7 6 2022 0 3 3 3 3 2023 0 3 3 3 3 2024 0 2 2 2 2 2025 0 1 1 1 1 2026 0 1 1 1 1 Q1 false 10052098 false false false 2014-12-08T12:30:05.000+0000 2014-09-09T11:30:05.000+0000 Doktori Iskola (SE); Molekuláris Farmakológia Kutatócsoport (KOKI / GYO) 2 14 2 2 0 true 10066925 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 5464183 /api/authorship/5464183 1 0.5 true false Author 10052098 /api/author/10052098 Gölöncsér Flóra true 10052098 true Goloncser F true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20241308 true PersonAuthorship 5464184 /api/authorship/5464184 2 0.5 false true true Author 10008942 /api/author/10008942 Sperlágh Beáta true 10008942 true Sperlagh B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20241307 true PublicationIdentifier 887219 /api/publicationidentifier/887219 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1186/1129-2377-15-24 https://doi.org/10.1186/1129-2377-15-24 false 944960 true PublicationIdentifier 887217 /api/publicationidentifier/887217 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000336227100001 https://www.webofscience.com/wos/woscc/full-record/000336227100001 false 1165820 true PublicationIdentifier 887218 /api/publicationidentifier/887218 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84907885567 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84907885567 false 1402543 true PublicationIdentifier 887220 /api/publicationidentifier/887220 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 24885962 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24885962&dopt=Abstract false 944961 true Classification 12125 /api/classification/12125 true true Classification 12548 /api/classification/12548 true true Classification 12215 /api/classification/12215 true true SjrRating 11059661 /api/sjrrating/11059661 19 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2703 /api/classificationexternal/2703 true 2703 true Q1 DIRECT true true /api/publication/2729280 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10052098"><a href="/gui2/?type=authors&mode=browse&sel=10052098" target="_blank">Goloncser F (<span class="authorship-author-name">Gölöncsér Flóra</span> <span class="authorAux-mtmt"> idegtudományok</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Molecular Pharmacology; <span title="Semmelweis University">SU</span>/School of Ph. D. Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008942"><a href="/gui2/?type=authors&mode=browse&sel=10008942" target="_blank">Sperlagh B ✉ (<span class="authorship-author-name">Sperlágh Beáta</span> <span class="authorAux-mtmt"> Neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Pharmacology">DP</span>/Laboratory of Molecular Pharmacology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2729280" target="_blank">Effect of genetic deletion and pharmacological antagonism of P2X7 receptors in a mouse animal model of migraine</a></div> <div> <span class="journal-title">JOURNAL OF HEADACHE AND PAIN</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1129-2369">1129-2369</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1129-2377">1129-2377</a>)</span>: <span class="journal-volume">15</span> <span class="page"> Paper 24. 8 p. </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1186/1129-2377-15-24" target="_blank" href="https://doi.org/10.1186/1129-2377-15-24"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000336227100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000336227100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84907885567" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84907885567"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="24885962" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24885962&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Anesthesiology and Pain Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Neurology (clinical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 39</span> | Independent citation: 37 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 37 | Number of citations in Scopus:&nbsp;37 | WoS/Scopus assigned:&nbsp;39 | Number of citations with DOI:&nbsp;39 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2729280&sort=publishedYear,desc&sort=title"> Number of cited publications: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2729280</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 2729280</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2023.02.02. 15:05 Rita Tichy (SE_KK_Admin5_TR, admin) </div> <div class="lockedBy">Centrally managed 2024.10.17. 18:20 Évi Nemec (MTMT Központi 3, admin) Gusztáv Ladányi (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Cited By :31 Export Date: 8 June 2023 CODEN: JHPOA Correspondence Address: Sperlágh, B.; Laboratory of Molecular Pharmacology, Budapest, Szigony u., 43, Hungary; email: sperlagh@koki.hu Chemicals/CAS: glyceryl trinitrate, 55-63-0, 80738-44-9 Funding details: TÉT_10-1-2011-0050...</pre> </div></div>