https://m2.mtmt.hu/ eng 2026-10-23 18:03 JournalArticle 2726660 APPROVED true Lendület Laboratory of Network Neurophysiology, Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Division of Medical Gene Technology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :23 Export Date: 28 January 2025 CODEN: HIPPE Correspondence Address: Hájos, N.; Institute of Experimental Medicine, Hungary Chemicals/CAS: Receptor, Cannabinoid, CB1 0 2018-03-04T14:08:14.000+0000 false 2726660 2026-10-21T10:21:17.757+0000 2024-09-09T11:08:18.241+0000 2014-09-02T08:03:03.000+0000 true 10023475 Papp Orsolya /api/author/10023475 Author true 10023475 2025-04-24T08:33:37.542+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szabo, GG Anatomically heterogeneous populations of CB cannabinoid receptor-expressing interneurons in the CA3 region of the hippocampus show homogeneous input-output characteristics. true true /api/journal/1780 REVIEWED true false 1780 false 1780 true 1050-9631 1098-1063 Journal FOREIGN 24 12 1506 1523 1506 18 2014 A subpopulation of GABAergic cells in cortical structures expresses CB1 cannabinoid receptors (CB1 ) on their axon terminals. To understand the function of these interneurons in information processing, it is necessary to uncover how they are embedded into neuronal circuits. Therefore, the proportion of GABAergic terminals expressing CB1 and the morphological and electrophysiological properties of CB1 -immunoreactive interneurons should be revealed. We investigated the ratio and the origin of CB1 -expressing inhibitory boutons in the CA3 region of the hippocampus. Using immunocytochemical techniques, we estimated that approximately 40% of GABAergic axon terminals in different layers of CA3 also expressed CB1 . To identify the inhibitory cell types expressing CB1 in this region, we recorded and intracellularly labeled interneurons in hippocampal slices. CB1 -expressing interneurons showed distinct axonal arborization, and were classified as basket cells, mossy-fiber-associated cells, dendritic-layer-innervating cells or perforant-path-associated cells. In each morphological category, a substantial variability in axonal projection was observed. In contrast to the diverse morphology, the active and passive membrane properties were found to be rather similar. Using paired recordings, we found that pyramidal cells displayed large and fast unitary postsynaptic currents in response to activating basket and mossy-fiber-associated cells, while they showed slower and smaller synaptic events in pairs originating from interneurons that innervate the dendritic layer, which may be due to dendritic filtering. In addition, CB1 activation significantly reduced the amplitude of the postsynaptic currents in each cell pair tested. Our data suggest that CB1 -expressing interneurons with different axonal projections have comparable physiological characteristics, contributing to a similar proportion of GABAergic inputs along the somato-dendritic axis of CA3 pyramidal cells. (c) 2014 Wiley Periodicals, Inc. 2014 817523 true true true false true false GREEN GREEN 2026-10-21 true https://real.mtak.hu/21992 true 10030885 Bálint Eszter /api/admin/10030885 Admin true 10030885 23 0 23 15 11 23 23 23 23 23 23 15 15 15 8 0 23 15 23 15 0 35 35 Folyóiratcikk Journal Article 24 23 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2015 0 3 2 3 2 2016 0 2 1 2 1 2017 0 6 2 6 2 2018 0 1 0 1 0 2019 0 0 0 0 0 2020 0 3 3 3 3 2021 0 4 4 4 4 2022 0 3 3 3 3 2023 0 1 0 1 0 Q1 false false false false 2015-03-15T09:44:49.000+0000 2014-12-15T09:44:49.000+0000 Lendület Hálózat-Idegélettani Kutatócsoport (KOKI / CHO); Molekuláris Biológiai és Genetikai Kutatócsoport (MTAKOKI / GFO) 4 25 2 5 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 5459004 /api/authorship/5459004 1 0.2 true false Szabo GG true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20231661 true PersonAuthorship 5459005 /api/authorship/5459005 2 0.2 false false Author 10023475 /api/author/10023475 Papp Orsolya true 10023475 true Papp OI true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20231660 true PersonAuthorship 5459006 /api/authorship/5459006 3 0.2 false false Author 198 /api/author/198 Máté Zoltán true 198 true Mate Z true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20231659 true PersonAuthorship 5459007 /api/authorship/5459007 4 0.2 false false Author 10009842 /api/author/10009842 Szabó Gábor true 10009842 true Szabo G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20231658 true PersonAuthorship 5459008 /api/authorship/5459008 5 0.2 false true Author 10010484 /api/author/10010484 Hájos Norbert true 10010484 true Hajos N true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20231657 true PublicationIdentifier 885589 /api/publicationidentifier/885589 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true PAY false IDENTICAL 10.1002/hipo.22330 https://doi.org/10.1002/hipo.22330 false 942388 true PublicationIdentifier 885591 /api/publicationidentifier/885591 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GREEN true NO 21992 https://real.mtak.hu/21992 false 1077095 true PublicationIdentifier 885587 /api/publicationidentifier/885587 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000345336600010 https://www.webofscience.com/wos/woscc/full-record/000345336600010 false 1553309 true PublicationIdentifier 885588 /api/publicationidentifier/885588 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84911001628 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84911001628 false 1734099 true PublicationIdentifier 885590 /api/publicationidentifier/885590 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 25044969 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25044969&dopt=Abstract false 942389 true Classification 12125 /api/classification/12125 true true SjrRating 11068079 /api/sjrrating/11068079 9 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2805 /api/classificationexternal/2805 true 2805 true Q1 DIRECT true true /api/publication/2726660 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Szabo GG </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023475"><a href="/gui2/?type=authors&mode=browse&sel=10023475" target="_blank">Papp OI (<span class="authorship-author-name">Papp Orsolya</span> <span class="authorAux-mtmt"> Idegélettan</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Lendület Hálózat-Idegélettani Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="198"><a href="/gui2/?type=authors&mode=browse&sel=198" target="_blank">Mate Z (<span class="authorship-author-name">Máté Zoltán</span> <span class="authorAux-mtmt"> Molekuláris biológia, genetika</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Gene Technology and Developmental Neurobiology">DGTDN</span>/Laboratory of Molecular Biology and Genetics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009842"><a href="/gui2/?type=authors&mode=browse&sel=10009842" target="_blank">Szabo G (<span class="authorship-author-name">Szabó Gábor</span> <span class="authorAux-mtmt"> Molekuláris és sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Gene Technology and Developmental Neurobiology">DGTDN</span>/Laboratory of Molecular Biology and Genetics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010484"><a href="/gui2/?type=authors&mode=browse&sel=10010484" target="_blank">Hajos N (<span class="authorship-author-name">Hájos Norbert</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Lendület Hálózat-Idegélettani Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2726660" target="_blank">Anatomically heterogeneous populations of CB cannabinoid receptor-expressing interneurons in the CA3 region of the hippocampus show homogeneous input-output characteristics.</a></div> <div> <span class="journal-title">HIPPOCAMPUS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1050-9631">1050-9631</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1098-1063">1098-1063</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">12</span> <span class="page"> pp 1506-1523 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Pay "> <a style="color:blue" title="10.1002/hipo.22330" target="_blank" href="https://doi.org/10.1002/hipo.22330"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="21992" target="_blank" href="https://real.mtak.hu/21992"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000345336600010" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000345336600010"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84911001628" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84911001628"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="25044969" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25044969&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cognitive Neuroscience&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 23</span> | Independent citation: 15 | Self citation: 8 | Unknown citation: 0 | Number of citations in WoS: 23 | Number of citations in Scopus:&nbsp;23 | WoS/Scopus assigned:&nbsp;23 | Number of citations with DOI:&nbsp;23 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2726660&sort=publishedYear,desc&sort=title"> Number of cited publications: 35 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2726660</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 2726660</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2024.09.09. 13:08 Annamária Boros (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Lendület Laboratory of Network Neurophysiology, Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Division of Medical Gene Technology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Cited By :23 Export D...</pre> </div></div>