https://m2.mtmt.hu/ eng 2026-10-24 16:06 JournalArticle 2721604 VALIDATED true Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Pázmány Péter Catholic University, H-1083 Budapest, Hungary Semmelweis University, H-1085 Budapest, Hungary Cited By :143 Export Date: 8 June 2023 CODEN: JNRSD Correspondence Address: Gulyás, A. I.; Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony utca 43, H-1083 Budapest, Hungary; email: gulyas@koki.hu Chemicals/CAS: 3 amino 2 (3 carboxypropyl) 6 (4 methoxyphenyl)pyridazinium bromide, 104104-50-9; 6 nitro 7 sulfamoylbenzo[f]quinoxaline 2,3 dione, 118876-58-7; parvalbumin, 56094-12-3, 83667-75-8; rhodopsin, 60383-01-9, 9009-81-8; tetrodotoxin, 4368-28-9, 4664-41-9; Agatoxins; Anesthetics, Local; Ank3 protein, mouse; Ankyrins; Calcium Channel Blockers; channelrhodopsin 2, mouse; Parvalbumins; Rhodopsin; Tetrodotoxin Funding details: Seventh Framework Programme, FP7, 294313 0 2018-02-05T08:18:07.000+0000 false 2721604 2026-10-22T08:19:23.022+0000 2025-12-27T15:52:56.740+0000 2014-08-26T12:15:34.000+0000 true 10009114 Gulyás Attila /api/author/10009114 Author true 10009114 2025-12-27T15:52:56.533+0000 2025-12-27T15:52:56.717+0000 true 521 Szuper Admin /api/admin/521 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Schlingloff, D Mechanisms of sharp wave initiation and ripple generation. true true /api/journal/2707 REVIEWED true false 2707 false 2707 true 0270-6474 1529-2401 Journal FOREIGN 34 34 11385 11398 11385 14 2014 Replay of neuronal activity during hippocampal sharp wave-ripples (SWRs) is essential in memory formation. To understand the mechanisms underlying the initiation of irregularly occurring SWRs and the generation of periodic ripples, we selectively manipulated different components of the CA3 network in mouse hippocampal slices. We recorded EPSCs and IPSCs to examine the buildup of neuronal activity preceding SWRs and analyzed the distribution of time intervals between subsequent SWR events. Our results suggest that SWRs are initiated through a combined refractory and stochastic mechanism. SWRs initiate when firing in a set of spontaneously active pyramidal cells triggers a gradual, exponential buildup of activity in the recurrent CA3 network. We showed that this tonic excitatory envelope drives reciprocally connected parvalbumin-positive basket cells, which start ripple-frequency spiking that is phase-locked through reciprocal inhibition. The synchronized GABAA receptor-mediated currents give rise to a major component of the ripple-frequency oscillation in the local field potential and organize the phase-locked spiking of pyramidal cells. Optogenetic stimulation of parvalbumin-positive cells evoked full SWRs and EPSC sequences in pyramidal cells. Even with excitation blocked, tonic driving of parvalbumin-positive cells evoked ripple oscillations. Conversely, optogenetic silencing of parvalbumin-positive cells interrupted the SWRs or inhibited their occurrence. Local drug applications and modeling experiments confirmed that the activity of parvalbumin-positive perisomatic inhibitory neurons is both necessary and sufficient for ripple-frequency current and rhythm generation. These interneurons are thus essential in organizing pyramidal cell activity not only during gamma oscillation, but, in a different configuration, during SWRs. true 2014 797941 true true true false true false GREEN GREEN 2026-10-22 true https://real.mtak.hu/14354 true 10050617 Nagy Sára /api/admin/10050617 Admin true 10050617 213 0 213 202 24 211 213 211 203 213 213 202 202 202 11 0 213 202 213 202 0 29 29 Folyóiratcikk Journal Article 24 209 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 2 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2015 0 11 10 11 10 2016 0 18 16 18 16 2017 0 17 15 17 15 2018 0 19 18 19 18 2019 0 21 21 21 21 2020 0 20 20 20 20 2021 0 11 11 11 11 2022 0 17 16 17 16 2023 0 20 20 20 20 2024 0 23 21 23 21 2025 0 19 17 19 17 2026 0 17 17 17 17 D1 true 10011500,10009114 false false false 2018-02-05T08:18:07.000+0000 2014-08-26T12:18:32.000+0000 Agykéreg Kutatócsoport (KOKI / CHO); Celluláris és Hálózat-neurobiológiai Osztály (KOKI); Doktori Iskola (SE); Információs Technológiai és Bionikai Kar (PPKE); Lendület Hálózat-Idegélettani Kutatócsoport (KOKI / CHO) 5 25 5 5 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 5441542 /api/authorship/5441542 1 0.2 true false Author 10053077 /api/author/10053077 Schlingloff Dániel true 10053077 true Schlingloff D true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20209746 true PersonAuthorship 5441543 /api/authorship/5441543 2 0.2 false false Author 10011500 /api/author/10011500 Káli Szabolcs true 10011500 true Kali S true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20209745 true PersonAuthorship 5441544 /api/authorship/5441544 3 0.2 false false Author 10000275 /api/author/10000275 Freund Tamás true 10000275 true Freund TF true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20209744 true PersonAuthorship 5441545 /api/authorship/5441545 4 0.2 false false Author 10010484 /api/author/10010484 Hájos Norbert true 10010484 true Hajos N true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20209743 true PersonAuthorship 5441546 /api/authorship/5441546 5 0.2 false true Author 10009114 /api/author/10009114 Gulyás Attila true 10009114 true Gulyas AI true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20209742 true PublicationIdentifier 882731 /api/publicationidentifier/882731 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1523/JNEUROSCI.0867-14.2014 https://doi.org/10.1523/JNEUROSCI.0867-14.2014 false 932732 true PublicationIdentifier 882733 /api/publicationidentifier/882733 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GREEN true NO 14354 https://real.mtak.hu/14354 false 934223 true PublicationIdentifier 882729 /api/publicationidentifier/882729 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000341312600022 https://www.webofscience.com/wos/woscc/full-record/000341312600022 false 1034297 true PublicationIdentifier 882730 /api/publicationidentifier/882730 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84906057270 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84906057270 false 1457387 true PublicationIdentifier 882732 /api/publicationidentifier/882732 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false IDENTICAL 25143618 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25143618&dopt=Abstract false 932733 true Classification 12125 /api/classification/12125 true true SjrRating 11097833 /api/sjrrating/11097833 11 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2801 /api/classificationexternal/2801 true 2801 true D1 DIRECT true true /api/publication/2721604 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10053077"><a href="/gui2/?type=authors&mode=browse&sel=10053077" target="_blank">Schlingloff D (<span class="authorship-author-name">Schlingloff Dániel</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/Department of Cellular and Network Neurobiology; <span title="Semmelweis University">SU</span>/School of Ph. D. Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011500"><a href="/gui2/?type=authors&mode=browse&sel=10011500" target="_blank">Kali S (<span class="authorship-author-name">Káli Szabolcs</span> <span class="authorAux-mtmt"> Elméleti neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cerebral Cortex Research; <span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000275"><a href="/gui2/?type=authors&mode=browse&sel=10000275" target="_blank">Freund TF (<span class="authorship-author-name">Freund Tamás</span> <span class="authorAux-mtmt"> Neurobiológia, idegtudomány</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cerebral Cortex Research; <span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010484"><a href="/gui2/?type=authors&mode=browse&sel=10010484" target="_blank">Hajos N (<span class="authorship-author-name">Hájos Norbert</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Lendület Hálózat-Idegélettani Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009114"><a href="/gui2/?type=authors&mode=browse&sel=10009114" target="_blank">Gulyas AI (<span class="authorship-author-name">Gulyás Attila</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cerebral Cortex Research</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2721604" target="_blank">Mechanisms of sharp wave initiation and ripple generation.</a></div> <div> <span class="journal-title">JOURNAL OF NEUROSCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0270-6474">0270-6474</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1529-2401">1529-2401</a>)</span>: <span class="journal-volume">34</span> <span class="journal-issue">34</span> <span class="page"> pp 11385-11398 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1523/JNEUROSCI.0867-14.2014" target="_blank" href="https://doi.org/10.1523/JNEUROSCI.0867-14.2014"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="14354" target="_blank" href="https://real.mtak.hu/14354"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000341312600022" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000341312600022"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84906057270" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84906057270"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="25143618" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25143618&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 213</span> | Independent citation: 202 | Self citation: 11 | Unknown citation: 0 | Number of citations in WoS: 211 | Number of citations in Scopus:&nbsp;203 | WoS/Scopus assigned:&nbsp;213 | Number of citations with DOI:&nbsp;213 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2721604&sort=publishedYear,desc&sort=title"> Number of cited publications: 29 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2721604</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 2721604</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2025.12.27. 16:52 Admin Szuper (admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1083 Budapest, Hungary Pázmány Péter Catholic University, H-1083 Budapest, Hungary Semmelweis University, H-1085 Budapest, Hungary Cited By :143 Export Date: 8 June 2023 CODEN: JNRSD C...</pre> </div></div>