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1664-3224", "pIssn" : "1664-3224", "eIssn" : "1664-3224", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 10023324, "snippet" : true }, "volume" : "9", "internalId" : "272", "firstPageOrInternalIdForSort" : "272", "publishedYear" : 2018, "abstractText" : "Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mtb). In the lungs, macrophages and neutrophils are the first immune cells that have contact with the infecting mycobacteria. Neutrophils are phagocytic cells that kill microorganisms through several mechanisms, which include the lytic enzymes and antimicrobial peptides that are found in their lysosomes, and the production of reactive oxygen species. Neutrophils also release extracellular vesicles (EVs) (100-1,000 nm in diameter) to the extracellular milieu; these EVs consist of a lipid bilayer surrounding a hydrophilic core and participate in intercellular communication. We previously demonstrated that human neutrophils infected in vitro with Mtb H37Rv release EVs (EV-TB), but the effect of these EVs on other cells relevant for the control of Mtb infection, such as macrophages, has not been completely analyzed. In this study, we characterized the EVs produced by non-stimulated human neutrophils (EV-NS), and the EVs produced by neutrophils stimulated with an activator (PMA), a peptide derived from bacterial proteins (fMLF) or Mtb, and observed that the four EVs differed in their size. Ligands for toll-like receptor (TLR) 2/6 were detected in EV-TB, and these EVs favored a modest increase in the expression of the co-stimulatory molecules CD80, a higher expression of CD86, and the production of higher amounts of TNF-a and IL-6, and of lower amounts of TGF-β, in autologous human macrophages, compared with the other EVs. EV-TB reduced the amount of intracellular Mtb in macrophages, and increased superoxide anion production in these cells. TLR2/6 ligation and superoxide anion production are known inducers of autophagy; accordingly, we found that EV-TB induced higher expression of the autophagy-related marker LC3-II in macrophages, and the co-localization of LC3-II with Mtb inside infected macrophages. The intracellular mycobacterial load increased when autophagy was inhibited with wortmannin in these cells. In conclusion, our results demonstrate that neutrophils produce different EVs in response to diverse activators, and that EV-TB activate macrophages and promote the clearance of intracellular Mtb through early superoxide anion production and autophagy induction, which is a novel role for neutrophil-derived EVs in the immune response to Mtb. © 2018 Alvarez-Jiménez, Leyva-Paredes, García-Martínez, Vázquez-Flores, García-Paredes, Campillo-Navarro, Romo-Cruz, Rosales-García, Castañeda-Casimiro, González-Pozos, Hernández, Wong-Baeza, García-Pérez, Ortiz-Navarrete, Estrada-Parra, Serafín-López, Wong-Baeza, Chacón-Salinas and Estrada-García.", "keywords" : [ { "otype" : "Keyword", "mtid" : 509, "link" : "/api/keyword/509", "label" : "PHOSPHATIDYLSERINE", "published" : true, "oldId" : 509, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1699, "link" : "/api/keyword/1699", "label" : "ARTICLE", "published" : true, "oldId" : 1699, "snippet" : true }, { "otype" : "Keyword", "mtid" : 2197, 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E.B., Lyadova, I.V., Kondratieva, T.K., Majorov, K.B., Scheglov, I.V., Orlova, M.O., Neutrophil responses to Mycobacterium tuberculosis infection in genetically susceptible and resistant mice (2005) Infect Immun, 73 (3), pp. 1744-1753; \n\nEum, S.Y., Kong, J.H., Hong, M.S., Lee, Y.J., Kim, J.H., Hwang, S.H., Neutrophils are the predominant infected phagocytic cells in the airways of patients with active pulmonary TB (2010) Chest, 137 (1), pp. 122-128; \n\nJones, G.S., Amirault, H.J., Andersen, B.R., Killing of Mycobacterium tuberculosis by neutrophils: a nonoxidative process (1990) J Infect Dis, 162 (3), pp. 700-704; \n\nJena, P., Mohanty, S., Mohanty, T., Kallert, S., Morgelin, M., Lindstrom, T., Azurophil granule proteins constitute the major mycobactericidal proteins in human neutrophils and enhance the killing of mycobacteria in macrophages (2012) PLoS One, 7 (12); \n\nRamos-Kichik, V., Mondragon-Flores, R., Mondragon-Castelan, M., Gonzalez-Pozos, S., Muniz-Hernandez, S., Rojas-Espinosa, O., Neutrophil extracellular traps are induced by Mycobacterium tuberculosis (2009) Tuberculosis (Edinb), 89 (1), pp. 29-37; \n\nMorel, C., Badell, E., Abadie, V., Robledo, M., Setterblad, N., Gluckman, J.C., Mycobacterium bovis BCG-infected neutrophils and dendritic cells cooperate to induce specific T cell responses in humans and mice (2008) Eur J Immunol, 38 (2), pp. 437-447; \n\nStein, J.M., Luzio, J.P., Ectocytosis caused by sublytic 452 autologous complement attack on human neutrophils (1991) The sorting of endogenous plasma-membrane proteins and lipids into shed vesicles. Biochem J, 274 (PART. 2), pp. 381-386; \n\nGasser, O., Hess, C., Miot, S., Deon, C., Sanchez, J.C., Schifferli, J.A., Characterisation and properties of ectosomes released by human polymorphonuclear neutrophils (2003) Exp Cell Res, 285 (2), pp. 243-257; \n\nNusse, O., Lindau, M., The dynamics of exocytosis in human neutrophils (1988) J Cell Biol, 107 (6 PART. 1), pp. 2117-2123; \n\nEken, C., Sadallah, S., Martin, P.J., Treves, S., Schifferli, J.A., Ectosomes of polymorphonuclear neutrophils activate multiple signaling pathways in macrophages (2013) Immunobiology, 218 (3), pp. 382-392; \n\nHess, C., Sadallah, S., Hefti, A., Landmann, R., Schifferli, J.A., Ectosomes released by human neutrophils are specialized functional units (1999) J Immunol, 163 (8), pp. 4564-4573; \n\nTimár, C.I., Lorincz, A.M., Csepanyi-Komi, R., Valyi-Nagy, A., Nagy, G., Buzas, E.I., Antibacterial effect of microvesicles released from human neutrophilic granulocytes (2013) Blood, 121 (3), pp. 510-518; \n\nGonzalez-Cano, P., Mondragon-Flores, R., Sanchez-Torres, L.E., Gonzalez-Pozos, S., Silva-Miranda, M., Monroy-Ostria, A., Mycobacterium tuberculosis H37Rv induces ectosome release in human polymorphonuclear neutrophils (2010) Tuberculosis (Edinb), 90 (2), pp. 125-134; \n\nAga, E., Katschinski, D.M., van Zandbergen, G., Laufs, H., Hansen, B., Muller, K., Inhibition of the spontaneous apoptosis of neutrophil granulocytes by the intracellular parasite Leishmania major (2002) J Immunol, 169 (2), pp. 898-905; \n\nSpittler, A., Set-Up of the CytoFLEX for Extracellular Vesicle Measurement (2016), http://molbiol.ru/forums/index.php?act=Attach&type=post&id=235071, Medical University of Vienna; Campillo-Navarro, M., Leyva-Paredes, K., Donis-Maturano, L., Gonzalez-Jimenez, M., Paredes-Vivas, Y., Cerbulo-Vazquez, A., Listeria monocytogenes induces mast cell extracellular traps (2017) Immunobiology, 222 (2), pp. 432-439; \n\nEken, C., Gasser, O., Zenhaeusern, G., Oehri, I., Hess, C., Schifferli, J.A., Polymorphonuclear neutrophil-derived ectosomes interfere with the maturation of monocyte-derived dendritic cells (2008) J Immunol, 180 (2), pp. 817-824; \n\nNomura, S., Tandon, N.N., Nakamura, T., Cone, J., Fukuhara, S., Kambayashi, J., High-shear-stress induced activation of platelets and microparticles enhances expression of cell adhesion molecules in THP-1 and endothelial cells (2001) Atherosclerosis, 158 (2), pp. 277-287; \n\nDalli, J., Montero-Melendez, T., Norling, L.V., Yin, X., Hinds, C., Haskard, D., Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties (2013) Mol Cell Proteomics, 12 (8), pp. 2205-2219; \n\nMarinho, F.A., de Paula, R.R., Mendes, A.C., de Almeida, L.A., Gomes, M.T., Carvalho, N.B., Toll-like receptor 6 senses Mycobacterium avium and is required for efficient control of mycobacterial infection (2013) Eur J Immunol, 43 (9), pp. 2373-2385; \n\nSieling, P.A., Chung, W., Duong, B.T., Godowski, P.J., Modlin, R.L., Toll-like receptor 2 ligands as adjuvants for human Th1 responses (2003) J Immunol, 170 (1), pp. 194-200; \n\nMacMicking, J.D., North, R.J., LaCourse, R., Mudgett, J.S., Shah, S.K., Nathan, C.F., Identification of nitric oxide synthase as a protective locus against tuberculosis (1997) Proc Natl Acad Sci U S A, 94 (10), pp. 5243-5248; \n\nLee, P.P., Chan, K.W., Jiang, L., Chen, T., Li, C., Lee, T.L., Susceptibility to mycobacterial infections in children with X-linked chronic granulomatous disease: a review of 17 patients living in a region endemic for tuberculosis (2008) Pediatr Infect Dis J, 27 (3), pp. 224-230; \n\nShin, D.M., Yuk, J.M., Lee, H.M., Lee, S.H., Son, J.W., Harding, C.V., Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling (2010) Cell Microbiol, 12 (11), pp. 1648-1665; \n\nVural, A., Kehrl, J.H., Autophagy in macrophages: impacting inflammation and bacterial infection (2014) Scientifica (Cairo), 2014, p. 825463; \n\nGutierrez, M.G., Master, S.S., Singh, S.B., Taylor, G.A., Colombo, M.I., Deretic, V., Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages (2004) Cell, 119 (6), pp. 753-766; \n\nBlommaart, E.F., Krause, U., Schellens, J.P., Vreeling-Sindelarova, H., Meijer, A.J., The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes (1997) Eur J Biochem, 243 (1-2), pp. 240-246; \n\nJung, C.H., Jun, C.B., Ro, S.H., Kim, Y.M., Otto, N.M., Cao, J., ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery (2009) Mol Biol Cell, 20 (7), pp. 1992-2003; \n\nScott, R.E., Maercklein, P.B., Plasma membrane vesiculation in 3T3 and SV3T3 cells II. Factors affecting the process of vesiculation (1979) J Cell Sci, 35, pp. 245-252; \n\nFujimi, S., Ogura, H., Tanaka, H., Koh, T., Hosotsubo, H., Nakamori, Y., Increased production of leukocyte microparticles with enhanced expression of adhesion molecules from activated polymorphonuclear leukocytes in severely injured patients (2003) J Trauma, 54 (1), pp. 114-119. , discussion 9-20; \n\nMeans, T.K., Jones, B.W., Schromm, A.B., Shurtleff, B.A., Smith, J.A., Keane, J., Differential effects of a toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses (2001) J Immunol, 166 (6), pp. 4074-4082; \n\nJones, B.W., Means, T.K., Heldwein, K.A., Keen, M.A., Hill, P.J., Belisle, J.T., Different toll-like receptor agonists induce distinct macrophage responses (2001) J Leukoc Biol, 69 (6), pp. 1036-1044; \n\nThoma-Uszynski, S., Stenger, S., Takeuchi, O., Ochoa, M.T., Engele, M., Sieling, P.A., Induction of direct antimicrobial activity through mammalian toll-like receptors (2001) Science, 291 (5508), pp. 1544-1547; \n\nBhatnagar, S., Shinagawa, K., Castellino, F.J., Schorey, J.S., Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo (2007) Blood, 110 (9), pp. 3234-3244; \n\nGiri, P.K., Kruh, N.A., Dobos, K.M., Schorey, J.S., Proteomic analysis identifies highly antigenic proteins in exosomes from M (2010) tuberculosis-infected and culture filtrate protein-treated macrophages. Proteomics, 10 (17), pp. 3190-3202; \n\nSingh, P.P., Li, L., Schorey, J.S., Exosomal RNA from Mycobacterium tuberculosis-infected cells is functional in recipient macrophages (2015) Traffic, 16 (6), pp. 555-571; \n\nDuarte, T.A., Noronha-Dutra, A.A., Nery, J.S., Ribeiro, S.B., Pitanga, T.N., Lapa, E.S.J.R., Mycobacterium tuberculosis-induced neutrophil ectosomes decrease macrophage activation (2012) Tuberculosis (Edinb), 92 (3), pp. 218-225; \n\nSanjuan, M.A., Dillon, C.P., Tait, S.W., Moshiach, S., Dorsey, F., Connell, S., Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis (2007) Nature, 450 (7173), pp. 1253-1257; \n\nHarris, J., Hartman, M., Roche, C., Zeng, S.G., O'Shea, A., Sharp, F.A., Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation (2011) J Biol Chem, 11, pp. 9587-9597; \n\nKumar, R., Halder, P., Sahu, S.K., Kumar, M., Kumari, M., Jana, K., Identification of a novel role of ESAT-6-dependent miR-155 induction during infection of macrophages with Mycobacterium tuberculosis (2012) Cell Microbiol, 14 (10), pp. 1620-1631; \n\nOuimet, M., Koster, S., Sakowski, E., Ramkhelawon, B., van Solingen, C., Oldebeken, S., Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism (2016) Nat Immunol, 17 (6), pp. 677-686", "hasCitationDuplums" : false, "userChangeableUntil" : "2019-01-31T22:59:00.000+0000", "publishDate" : "2018-03-07T13:58:05.000+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 9, "ownerInstituteCount" : 32, "directInstituteCount" : 0, "authorCount" : 19, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/27200117", "label" : "Alvarez-Jiménez VD et al. 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