https://m2.mtmt.hu/ eng 2026-10-25 12:44 JournalArticle 2715409 VALIDATED true Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Department of Forensic Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary INSERM U862, Neurocentre Magendie, Bordeaux, France Department of Investigative Medicine, Hammersmith Hospital, Imperial College London, London, United Kingdom Department of Neuroscience, Faculty of Information Technology, Pázmány Péter Catholic University, Budapest, Hungary Cited By :22 Export Date: 28 January 2025 CODEN: POLNC Chemicals/CAS: cocaine and amphetamine regulated transcript peptide, 213994-61-7; gonadorelin, 33515-09-2, 9034-40-6; neurokinin B, 86933-75-7; substance P, 33507-63-0; Agouti-Related Protein; cocaine- and amphetamine-regulated transcript protein; Gonadotropin-Releasing Hormone; KISS1 protein, human; Kisspeptins; Nerve Tissue Proteins; Neurokinin B; Substance P Funding details: Seventh Framework Programme, FP7, 245009 Funding details: Seventh Framework Programme, FP7 0 2015-06-09T22:20:04.000+0000 false 2715409 2026-10-16T18:05:32.192+0000 2025-03-27T14:01:20.577+0000 2014-08-05T13:06:46.000+0000 true 10002755 Liposits Zsolt /api/author/10002755 Author true 10002755 2026-08-18T07:13:55.324+0000 2026-08-18T07:13:55.324+0000 2024-12-06T17:35:31.023+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Skrapits, K Colocalization of cocaine- and amphetamine-regulated transcript with kisspeptin and neurokinin B in the human infundibular region. true true /api/journal/10007440 REVIEWED true false 10007440 false 10007440 true 1932-6203 Journal FOREIGN 9 8 e103977 e103977 2014 Kisspeptin (KP)- and neurokinin B (NKB)- synthesizing neurons of the hypothalamic arcuate nucleus play a pivotal role in the regulation of pulsatile gonadotropin-releasing hormone (GnRH) secretion. Unlike in rodents and sheep, the homologous KP and NKB neurons in the human infundibular region rarely express dynorphin- but often exhibit Substance P (SP) immunoreactivity, indicating remarkable species differences in the neurochemical phenotype of these neurons. In search for additional neuropeptides in human KP and NKB neurons, we carried out immunofluorescent studies on hypothalamic sections obtained from five postmenopausal women. Colocalization experiments provided evidence for the presence of cocaine- and amphetamine-regulated transcript (CART) in 47.9+/-6.6% of KP-immunoreactive (IR) and 30.0+/-4.9% of NKB-IR perikarya and in 17.0+/-2.3% of KP-IR and 6.2+/-2.0% of NKB-IR axon varicosities. All three neuropeptides were present in 33.3+/-4.9% of KP-IR and 28.2+/-4.6% of NKB-IR somata, respectively, whereas triple-labeling showed lower incidences in KP-IR (14.3+/-1.8%) and NKB-IR (5.9+/-2.0%) axon varicosities. CART-IR KP and NKB neurons established contacts with other peptidergic cells, including GnRH-IR neurons and also sent projections to the infundibular stalk. KP and NKB fibers with CART often contained SP as well, while being distinct from CART fibers co-containing the orexigenic peptide agouti-related protein. Presence of CART in human, but not rodent, KP and NKB neurons represents a new example of species differences in the neuropeptide repertoire of mediobasal hypothalamic KP and NKB neurons. Target cells, receptor sites and physiological significance of CART in the efferent communication of KP and NKB neurons in primates require clarification. true true 2014 783248 true true true false true false GOLD 2026-10-16 true https://doi.org/10.1371/journal.pone.0103977 23 0 23 12 10 23 23 21 23 23 23 12 12 12 11 0 23 12 23 12 0 9 9 Folyóiratcikk Journal Article 24 22 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2015 0 4 2 4 2 2016 0 2 1 2 1 2017 0 2 2 2 2 2018 0 2 1 2 1 2019 0 2 1 2 1 2020 0 1 0 1 0 2021 0 4 2 4 2 2022 0 4 2 4 2 2023 0 0 0 0 0 2024 0 1 1 1 1 2025 0 0 0 0 0 2026 0 1 0 1 0 D1 A false false false false 2014-11-03T14:50:11.000+0000 2014-08-05T13:50:11.000+0000 Endokrin Neurobiológiai Kutatócsoport (KOKI / ENO); Információs Technológiai és Bionikai Kar (PPKE) 5 22 2 9 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 5426828 /api/authorship/5426828 1 0.111 true false Author 10020450 /api/author/10020450 Skrapits Katalin true 10020450 true Skrapits K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20184967 true PersonAuthorship 5426829 /api/authorship/5426829 2 0.11111111 false false Author 10036859 /api/author/10036859 Borsay Beáta Ágnes true 10036859 true Borsay BA true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20184966 true PersonAuthorship 5426830 /api/authorship/5426830 3 0.11111111 false false Author 10036799 /api/author/10036799 Herczeg László true 10036799 true Herczeg L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20184965 true PersonAuthorship 5426831 /api/authorship/5426831 4 0.11111111 false false Ciofi P true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20184964 true PersonAuthorship 5426832 /api/authorship/5426832 5 0.11111111 false false Bloom SR true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20184963 true PersonAuthorship 5426833 /api/authorship/5426833 6 0.11111111 false false Ghatei MA true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20184962 true PersonAuthorship 5426834 /api/authorship/5426834 7 0.11111111 false false Dhillo WS true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20184961 true PersonAuthorship 5426835 /api/authorship/5426835 8 0.11111111 false false Author 10002755 /api/author/10002755 Liposits Zsolt true 10002755 true Liposits Z true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20184960 true PersonAuthorship 5426836 /api/authorship/5426836 9 0.111 false true true Author 10011472 /api/author/10011472 Hrabovszky Erik true 10011472 true Hrabovszky E true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 20184959 true PublicationIdentifier 879275 /api/publicationidentifier/879275 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1371/journal.pone.0103977 https://doi.org/10.1371/journal.pone.0103977 false 921042 true PublicationIdentifier 879277 /api/publicationidentifier/879277 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GREEN true NO 14097 https://real.mtak.hu/14097 false 921698 true PublicationIdentifier 879273 /api/publicationidentifier/879273 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true false IDENTICAL 000339819800113 https://www.webofscience.com/wos/woscc/full-record/000339819800113 false 973929 true PublicationIdentifier 879274 /api/publicationidentifier/879274 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true false IDENTICAL 84905483124 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84905483124 false 973928 true PublicationIdentifier 879276 /api/publicationidentifier/879276 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true false NO 25084101 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25084101&dopt=Abstract false 921043 true Classification 10545 /api/classification/10545 true true Classification 12713 /api/classification/12713 true true Classification 12548 /api/classification/12548 true true Classification 10799 /api/classification/10799 true true Classification 12215 /api/classification/12215 true true MtaRating 10486385 /api/mtarating/10486385 RatingType 10023 /api/ratingtype/10023 PedTB Institute 14107 /api/institute/14107 0 false true false Pedagógiai Tudományos Bizottság Pedagógiai Tudományos Bizottság true 14107 true true true A true true MtaRating 519076 /api/mtarating/519076 RatingType 10007 /api/ratingtype/10007 SZTB Institute 14102 /api/institute/14102 0 false true false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true A nemzetközi true 19076 true MtaRating 11551131 /api/mtarating/11551131 RatingType 10010 /api/ratingtype/10010 RegTB Institute 14100 /api/institute/14100 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true B nemzetközi false true SjrRating 11058740 /api/sjrrating/11058740 24 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1101 /api/classificationexternal/1101 true 1101 true D1 DIRECT true true /api/publication/2715409 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10020450"><a href="/gui2/?type=authors&mode=browse&sel=10020450" target="_blank">Skrapits K (<span class="authorship-author-name">Skrapits Katalin</span> <span class="authorAux-mtmt"> neuroendokrinológia/reproduktív neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Endocrine Neurobiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10036859"><a href="/gui2/?type=authors&mode=browse&sel=10036859" target="_blank">Borsay BA (<span class="authorship-author-name">Borsay Beáta Ágnes</span> <span class="authorAux-mtmt"> igazságügyi orvostan</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10036799"><a href="/gui2/?type=authors&mode=browse&sel=10036799" target="_blank">Herczeg L (<span class="authorship-author-name">Herczeg László</span> <span class="authorAux-mtmt"> igazságügyi orvostan</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ciofi P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bloom SR </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ghatei MA </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dhillo WS </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002755"><a href="/gui2/?type=authors&mode=browse&sel=10002755" target="_blank">Liposits Z (<span class="authorship-author-name">Liposits Zsolt</span> <span class="authorAux-mtmt"> Neurobiológia, neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Endocrine Neurobiology; <span title="Pázmány Péter Catholic University">PPCU</span>/Információs Technológiai és Bionikai Kar</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011472"><a href="/gui2/?type=authors&mode=browse&sel=10011472" target="_blank">Hrabovszky E ✉ (<span class="authorship-author-name">Hrabovszky Erik</span> <span class="authorAux-mtmt"> Reproduktív endokrinológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Endocrine Neurobiology">DEN</span>/Laboratory of Endocrine Neurobiology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2715409" target="_blank">Colocalization of cocaine- and amphetamine-regulated transcript with kisspeptin and neurokinin B in the human infundibular region.</a></div> <div> <span class="journal-title">PLOS ONE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1932-6203">1932-6203</a>)</span>: <span class="journal-volume">9</span> <span class="journal-issue">8</span> <span class="page"> Paper e103977. </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1371/journal.pone.0103977" target="_blank" href="https://doi.org/10.1371/journal.pone.0103977"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="14097" target="_blank" href="https://real.mtak.hu/14097"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000339819800113" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000339819800113"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84905483124" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84905483124"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="25084101" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25084101&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Agricultural and Biological Sciences (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Pedagógiai Tudományos Bizottság HASSPHSII PedTB [1901-]&nbsp;&nbsp;&nbsp;A</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 23</span> | Independent citation: 12 | Self citation: 11 | Unknown citation: 0 | Number of citations in WoS: 21 | Number of citations in Scopus:&nbsp;23 | WoS/Scopus assigned:&nbsp;23 | Number of citations with DOI:&nbsp;23 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2715409&sort=publishedYear,desc&sort=title"> Number of cited publications: 9 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2715409</span> | <span class="status-data status-VALIDATED"> Validated </span> <span class="oldId">Old id: 2715409</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="lastModified">Last Modified: 2025.03.27. 15:01 Gusztáv Ladányi (MTMT API user, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Department of Forensic Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary INSERM U862, Neurocentre Magendie, Bordeaux, France Department of Investigative Medicine, Hammersmith Hosp...</pre> </div></div>