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None of the other authors have any financial affiliations or conflicts of interest to disclose. Dr De Rojas was supported by National Institutes of Health T32 predoctoral training grant T32-NS043126 and an American Academy of Neurology Medical Student Research Scholarship. Dr Hamilton was supported by the Robert Wood Johnson Foundation Harold Amos Medical Faculty Development Program. Dr Siegel was supported by grant 5R01DA023210-02 from the National Institutes of Health.\nPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States \n Department of Psychiatry, University of Pennsylvania, 125 S 31st St, Philadelphia, PA 19104, United States \n Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States \n Cited By :5 \n Export Date: 21 March 2020 \n CODEN: NRSRD \n Correspondence Address: Siegel, S.J.; Department of Psychiatry, University of Pennsylvania, 125 S 31st St, Philadelphia, PA 19104, United States; email: siegels@mail.med.upenn.edu\nPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States \n Department of Psychiatry, University of Pennsylvania, 125 S 31st St, Philadelphia, PA 19104, United States \n Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States \n Cited By :5 \n Export Date: 12 August 2020 \n CODEN: NRSRD \n Correspondence Address: Siegel, S.J.; Department of Psychiatry, University of Pennsylvania, 125 S 31st St, Philadelphia, PA 19104, United States; email: siegels@mail.med.upenn.edu\nPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States \n Department of Psychiatry, University of Pennsylvania, 125 S 31st St, Philadelphia, PA 19104, United States \n Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States \n Cited By :6 \n Export Date: 24 March 2021 \n CODEN: NRSRD \n Correspondence Address: Siegel, S.J.; Department of Psychiatry, 125 S 31st St, Philadelphia, PA 19104, United States; email: siegels@mail.med.upenn.edu \n Funding details: National Institute on Drug Abuse, NIDA, R01DA023210 \n Funding details: National Institute of Neurological Disorders and Stroke, NINDS, T32NS043126\nPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States \n Department of Psychiatry, University of Pennsylvania, 125 S 31st St, Philadelphia, PA 19104, United States \n Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States \n Cited By :6 \n Export Date: 28 March 2021 \n CODEN: NRSRD \n Correspondence Address: Siegel, S.J.; Department of Psychiatry, 125 S 31st St, Philadelphia, PA 19104, United States; email: siegels@mail.med.upenn.edu \n Funding details: National Institute on Drug Abuse, NIDA, R01DA023210 \n Funding details: National Institute of Neurological Disorders and Stroke, NINDS, T32NS043126\nFunding Agency and Grant Number: NuPathe; AbbottAbbott Laboratories; AstraZenecaAstraZeneca; AstellasAstellas Pharmaceuticals; National Institutes of Health T32 predoctoral training grantUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [T32-NS043126]; American Academy of Neurology Medical Student Research Scholarship; Robert Wood Johnson Foundation Harold Amos Medical Faculty Development ProgramRobert Wood Johnson Foundation (RWJF); National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [5R01DA023210-02]; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [T32NS043126] Funding Source: NIH RePORTER; NATIONAL INSTITUTE ON DRUG ABUSEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Drug Abuse (NIDA)European Commission [R01DA023210] Funding Source: NIH RePORTER\n Funding text: Dr Siegel has received research grants, consultation, and honoraria from NuPathe, Abbott, AstraZeneca, and Astellas that is unrelated to the content of this manuscript. 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