https://m2.mtmt.hu/ eng 2026-10-24 05:26 JournalArticle 2700206 APPROVED true 0 2016-08-25T10:32:27.000+0000 false 2700206 2026-10-16T17:26:58.803+0000 2025-12-11T10:31:19.113+0000 2014-06-24T11:48:18.000+0000 true 10010484 Hájos Norbert /api/author/10010484 Author true 10010484 2025-12-11T10:49:10.506+0000 2025-12-11T10:49:10.506+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szabo, GG Presynaptic Calcium Channel Inhibition Underlies CB1 Cannabinoid Receptor-Mediated Suppression of GABA Release true true /api/journal/2707 REVIEWED true false 2707 false 2707 true 0270-6474 1529-2401 Journal FOREIGN 34 23 7958 7963 7958 6 2014 CB1 cannabinoid receptors (CB1) are located at axon terminals and effectively control synaptic communication and thereby circuit operation widespread in the CNS. Although it is partially uncovered how CB1 activation leads to the reduction of synaptic excitation, the mechanisms of the decrease of GABA release upon activation of these cannabinoid receptors remain elusive. To determine the mechanisms underlying the suppression of synaptic transmission by CB1 at GABAergic synapses, we recorded unitary IPSCs (uIPSCs) at cholecystokinin-expressing interneuron-pyramidal cell connections and imaged presynaptic [Ca(2+)] transients in mouse hippocampal slices. Our results reveal a power function with an exponent of 2.2 between the amplitude of uIPSCs and intrabouton [Ca(2+)]. Altering CB1 function by either increasing endocannabinoid production or removing its tonic activity allowed us to demonstrate that CB1 controls GABA release by inhibiting Ca(2+) entry into presynaptic axon terminals via N-type (Cav2.2) Ca(2+) channels. These results provide evidence for modulation of intrabouton Ca(2+) influx into GABAergic axon terminals by CB1, leading to the effective suppression of synaptic inhibition. 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class="autype autype0"> <span class="author-name" mtid="10014206"><a href="/gui2/?type=authors&mode=browse&sel=10014206" target="_blank">Szabo GG (<span class="authorship-author-name">Szabó Gergely</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Lendület Hálózat-Idegélettani Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="194"><a href="/gui2/?type=authors&mode=browse&sel=194" target="_blank">Lenkey N<sup>*</sup> (<span class="authorship-author-name">Lenkey Nóra</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011496"><a href="/gui2/?type=authors&mode=browse&sel=10011496" target="_blank">Holderith N (<span class="authorship-author-name">Holderith Noémi</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10039582"><a href="/gui2/?type=authors&mode=browse&sel=10039582" target="_blank">Andrasi T (<span class="authorship-author-name">Andrási Tibor</span> <span class="authorAux-mtmt"> Elektrofiziológia</span>) </a> </span> <span class="author-affil">MTA Kísérleti Orvostudományi Kutatóintézet; <span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Lendület Hálózat-Idegélettani Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000499"><a href="/gui2/?type=authors&mode=browse&sel=10000499" target="_blank">Nusser Z<sup>**</sup> (<span class="authorship-author-name">Nusser Zoltán</span> <span class="authorAux-mtmt"> Celluláris idegélettan</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010484"><a href="/gui2/?type=authors&mode=browse&sel=10010484" target="_blank">Hajos N ✉ (<span class="authorship-author-name">Hájos Norbert</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="MTA Kísérleti Orvostudományi Kutatóintézet">IEMHAS</span>/<span title="Department of Cellular and Network Neurobiology">DCNN</span>/Lendület Hálózat-Idegélettani Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;2700206" target="_blank">Presynaptic Calcium Channel Inhibition Underlies CB1 Cannabinoid Receptor-Mediated Suppression of GABA Release</a></div> <div> <span class="journal-title">JOURNAL OF NEUROSCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0270-6474">0270-6474</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1529-2401">1529-2401</a>)</span>: <span class="journal-volume">34</span> <span class="journal-issue">23</span> <span class="page"> pp 7958-7963 </span> <span class="year">(2014)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Pay "> <a style="color:blue" title="10.1523/JNEUROSCI.0247-14.2014" target="_blank" href="https://doi.org/10.1523/JNEUROSCI.0247-14.2014"> DOI </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="21944" target="_blank" href="https://real.mtak.hu/21944"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000337630700022" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000337630700022"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="84901749087" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84901749087"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="24899717" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24899717&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 114</span> | Independent citation: 109 | Self citation: 5 | Unknown citation: 0 | Number of citations in WoS: 71 | Number of citations in Scopus:&nbsp;77 | WoS/Scopus assigned:&nbsp;79 | Number of citations with DOI:&nbsp;93 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;2700206&sort=publishedYear,desc&sort=title"> Number of cited publications: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 2700206</span> | <span class="status-data status-APPROVED"> Published </span> <span class="oldId">Old id: 2700206</span> | Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">MEDLINE</span> </div> <div class="funder"> Seventh Framework Programme(FP7, 293681) </div> <div class="notDuplums"><a target="_blank" href="/api/publication/2700206/notduplums">1 marked as not duplum</a> </div> <div class="lastModified">Last Modified: 2025.12.11. 11:31 András Balázs (MTMT Központ_, admin) </div> </div></div>