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Invasion of trophoblast cell lines is inhibited by miR-93 via MMP-2
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Preeclampsia (PE) is a serious pregnancy-related syndrome, which is characterized by gestational hypertension and proteinuria. The microRNA-93 (miR-93) is upregulated in the maternal plasma of patients with PE. However, the functional role of miR-93 in PE remains unknown. Here, we identified that miR-93 inhibits trophoblastic invasion, which is correlated with PE development. In immortalized trophoblast cell lines, transwell assay showed that miR-93 mimics significantly inhibited the migration and invasion of immortalized trophoblast cells, whereas miR-93 inhibitors significantly promoted cell migration and invasion. Moreover, luciferase assays confirmed that miR-93 directly bound to the 3' untranslated region of matrix metalloproteinase-2 (MMP-2), and western blotting showed that miR-93 suppressed the expression of MMP-2 at the protein levels. This study indicated that miR-93 inhibits MMP-2 and reduces migration and invasion of immortalized trophoblast cells. Thus, miR-93 may represent a potential therapeutic target for PE intervention. (C) 2017 Elsevier Ltd. All rights reserved.
2017
(Rigó János (Szülészet-nőgyógyászat...); 2017.10.05. 14:25:16)
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Pan, Q </span> <span class="author-type"> </span> ; <span class="author-name" > Niu, H </span> <span class="author-type"> </span> ; <span class="author-name" > Cheng, L </span> <span class="author-type"> </span> ; <span class="author-name" > Li, X </span> <span class="author-type"> </span> ; <span class="author-name" > Zhang, Q </span> <span class="author-type"> </span> ; <span class="author-name" > Ning, Y </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;26853043" mtid="26853043" target="_blank">Invasion of trophoblast cell lines is inhibited by miR-93 via MMP-2</a></div> <div class="pub-info"> <span class="journal-title">PLACENTA</span> <span class="journal-volume">53</span> <span class="page"> pp. 48-53. , 6 p. </span> <span class="year">(2017)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1016/j.placenta.2017.03.008" target="_blank" href="https://doi.org/10.1016/j.placenta.2017.03.008"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="000402072400008" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000402072400008"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85016289094" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85016289094"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="28487020" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=28487020&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://doi.org/10.1016/j.placenta.2018.11.002" target="_blank" href="https://doi.org/10.1016/j.placenta.2018.11.002"> VISSZAVONT </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="deleted-record">Zárolt</span> <span class="short-pub-mtid"> Közlemény:26853043 </span> <span class="status-holder"><span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span></span> <span class="pub-core"> Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Nem besorolt jellegű</span> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="autype autype0"> <span class="author-name" >Pan Q
</span>
;
<span class="author-name" >Niu H
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;
<span class="author-name" >Cheng L
</span>
;
<span class="author-name" >Li X
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;
<span class="author-name" >Zhang Q
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;
<span class="author-name" >Ning Y
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;26853043" target="_blank">Invasion of trophoblast cell lines is inhibited by miR-93 via MMP-2</a></div> <div> <span class="journal-title">PLACENTA</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0143-4004">0143-4004</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1532-3102">1532-3102</a>)</span>:
<span class="journal-volume">53</span>
<span class="page">
pp 48-53
</span> <span class="year">(2017)</span>
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Idézett közlemények száma: 1
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<div class="mtid"><span class="long-pub-mtid">Közlemény: 26853043</span>
| <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott
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<span class="oldId">Régi azonosító: 16853043</span> |
Idéző
| <span class="type-subtype">Folyóiratcikk
( Szakcikk
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| <span class="pub-category">Nem besorolt jellegű</span>
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<div class="lastModified">Utolsó módosítás: 2023.10.19. 15:29 Kovács Marcell (MTMT Közp., admin)
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<div class="lockedBy">Ideiglenesen zárolva 2023.10.19. 15:30 Kovács Marcell (MTMT Közp., admin)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: RETRACTED / VISSZAVONT</pre>
</div></div>