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Pharmaceutical, China \n Funding details: 201507004-002, 2015ZX09501004-002-004 \n Funding details: National Natural Science Foundation of China, NSFC, 81273604, 81320108029, 81573514 \n Funding details: Natural Science Foundation of Jiangsu Province, BK20151439 \n Funding details: Priority Academic Program Development of Jiangsu Higher Education Institutions, PAPD \n Funding text 1: This study was supported by the National Natural Science Foundation of China (grants 81273604, 81573514 to ZJ, 81320108029 to LZ); Natural Science Foundation of Jiangsu Province (BK20151439 to ZJ), Specific Fund for Public Interest Research of Traditional Chinese Medicine, Ministry of Finance (201507004-002 to LZ), National \"Major Scientific and Technological Special Project for Significant New Drugs Creation\" project (2015ZX09501004-002-004 to LZ), also this study was partially supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).", "unhandledTickets" : 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