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Astrocyte–endothelial interactions at the blood–brain barrier (2006) Nat. Rev. Neurosci., 7, pp. 41-53; \n\nAbbott, N.J., Patabendige, A.A., Dolman, D.E., Yusof, S.R., Begley, D.J., Structure and function of the blood–brain barrier (2010) Neurobiol. Dis., 37, pp. 13-25; \n\nAbbott, N.J., Dynamics of CNS barriers: evolution, differentiation, and modulation (2005) Cell Mol. Neurobiol., 25, pp. 5-23; \n\nAustinat, M., Braeuninger, S., Pesquero, J.B., Brede, M., Bader, M., Stoll, G., Renné, T., Kleinschnitz, C., Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edema (2009) Stroke, 40, pp. 285-293; \n\nBraun, S., Gaza, N., Werdehausen, R., Hermanns, H., Bauer, I., Durieux, M.E., Hollmann, M.W., Stevens, M.F., Ketamine induces apoptosis via the mitochondrial pathway in human lymphocytes and neuronal cells (2010) Br. J. Anaesth., 105, pp. 347-354; \n\nBrown, R.C., Davis, T.P., Calcium modulation of adherens and tight junction function: a potential mechanism for blood-brain barrier disruption after stroke (2002) Stroke, 33, pp. 1706-1711; \n\nCampbell, L.L., Tyson, J.A., Stackpole, E.E., Hokenson, K.E., Sherrill, H., McKeon, J.E., Kim, S.A., Hall, A.C., Assessment of general anaesthetic cytotoxicity in murine cortical neurones in dissociated culture (2011) Toxicology, 283, pp. 1-7; \n\nChang, C.Y., Lui, T.N., Lin, J.W., Lin, Y.L., Hsing, C.H., Wang, J.J., Chen, R.M., Roles of microRNA-1 in hypoxia-induced apoptotic insults to neural cells (2016) Arch. Toxicol., 90, pp. 191-202; \n\nChang, H.C., Chen, T.L., Chen, R.M., Cytoskeleton interruption in human hepatoma HepG2 cells induced by ketamine occurs possibly through suppression of calcium mobilization and mitochondrial function (2009) Drug Metab. Dispos., 37, pp. 24-31; \n\nChen, R.M., Chen, T.L., Lin, Y.L., Chen, T.G., Tai, Y.T., Ketamine reduces nitric oxide biosynthesis in human umbilical vein endothelial cells by down-regulating endothelial nitric oxide synthase expression and intracellular calcium levels (2005) Crit. Care Med., 33, pp. 1044-1049; \n\nChen, T.G., Chen, T.L., Chang, H.C., Tai, Y.T., Cherng, Y.G., Chang, Y.T., Oxidized low-density lipoprotein induces apoptotic insults to mouse cerebral endothelial cells via a Bax-mitochondria-caspase protease pathway (2007) Toxicol. Appl. Pharmacol., 219, pp. 42-53; \n\nChen, J.T., Chen, T.G., Chang, Y.C., Chen, C.Y., Chen, R.M., Roles of NMDARs in maintenance of the mouse cerebrovascular endothelial cell-constructed tight junction barrier (2016) Toxicology, 339, pp. 40-50; \n\nCrone, C., Olesen, S.P., Electrical resistance of brain microvascular endothelium (1982) Brain Res., 241, pp. 49-55; \n\nDe Bock, M., Wang, N., Decrock, E., Bol, M., Gadicherla, A.K., Culot, M., Cecchelli, R., Leybaert, L., Endothelial calcium dynamics, connexin channels and blood-brain barrier function (2013) Prog. Neurobiol., 108, pp. 1-20; \n\nDolor, R.J., Hurwitz, L.M., Mirza, Z., Strauss, H.C., Whorton, A.R., Regulation of extracellular calcium entry in endothelial cells: role of intracellular calcium pool (1990) Am. J. Physiol., 262, pp. C171-C181; \n\nDomino, E.F., Zsigmond, E.K., Domino, L.E., Domino, K.E., Kothary, S.P., Domino, S.E., Plasma levels of ketamine and two of its metabolites in surgical patients using a gas chromatographic mass fragmentographic assay (1982) Anesth. Analg., 61, pp. 87-92; \n\nEaston, A.S., Abbott, N.J., Bradykinin increases permeability by calcium and 5- lipoxygenase in the ECV304/C6 cell culture model of the blood–brain barrier (2002) Brain Res., 953, pp. 157-169; \n\nEngelhardt, B., Development of the blood–brain barrier (2003) Cell Tissue Res., 314, pp. 119-129; \n\nFang, H.W., Kao, W.Y., Lin, P.I., Chang, G.W., Hung, Y.J., Chen, R.M., Effects of polypropylene carbonate/poly(D,L-lactic) acid/tricalcium phosphate elastic composites on improving osteoblast maturation (2015) Ann. Biomed. Eng., 43 (8), pp. 1999-2009; \n\nFrancel, P.C., Bradykinin and neuronal injury (1992) J. Neurotrauma., 9, pp. S27-S45; \n\nFrancis, M., Waldrup, J., Qian, X., Taylor, M.S., Automated analysis of dynamic Ca2+ signals in image sequences (2014) J. Vis. Exp., 88; \n\nGardner, A.E., Dannemiller, F.J., Dean, D., Intracranial cerebrospinal fluid pressure in man during ketamine anesthesia (1972) Anesth. Analg., 51, pp. 741-745; \n\nGolias, C.H., Charalabopoulos, A., Stagikas, D., Charalabopoulos, K., Batistatou, A., The kinin system-bradykinin: biological effects and clinical implications. Multiple role of the kinin system-bradykinin (2007) Hippokratia, 11, pp. 124-128; \n\nGröger, M., Lebesgue, D., Pruneau, D., Relton, J., Kim, S.W., Nussberger, J., Plesnila, N., Release of bradykinin and expression of kinin B2 receptors in the brain: role for cell death and brain edema formation after focal cerebral ischemia in mice (2005) J. Cereb. Blood Flow Metab., 25, pp. 978-989; \n\nHall, J.M., Bradykinin receptors (1997) Gen. Pharmacol., 28, pp. 1-6; \n\nHimmelseher, S., Durieux, M.E., Revising a dogma: ketamine for patients with neurological injury? (2005) Anesth. Analg., 101, pp. 524-534; \n\nHowl, J., Payne, S.J., Bradykinin receptors as a therapeutic target (2003) Expert Opin. Ther. Targets, 7, pp. 277-285; \n\nHuber, J.D., Egleton, R.D., Davis, T.P., Molecular physiology and pathophysiology of tight junctions in the blood–brain barrier (2001) Trends Neurosci., 24, pp. 719-725; \n\nHudetz, J.A., Pagel, P.S., Neuroprotection by ketamine: a review of the experimental and clinical evidence (2010) J. Cardiothorac. Vasc. Anesth., 24, pp. 131-142; \n\nKudoh, A., Matsuki, A., Ketamine inhibits inositol 1,4,5-trisphosphate production depending on the extracellular Ca2+ concentration in neonatal rat cardiomyocytes (1999) Anesth. Analg., 89, pp. 1417-1422; \n\nKuwahara, M., Role of [Ca2+]i and F-actin on mesothelial barrier function (2014) Front. Physiol., 30 (5), p. 232; \n\nLeeb-Lundberg, L.M., Marceau, F., Müller- Esterl, W., Pettibone, D.J., Zuraw, B.L., International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences (2005) Pharmacol. Rev., 57, pp. 27-77; \n\nLin, Y.L., Chang, H.C., Chen, T.L., Chang, J.H., Chiu, W.T., Lin, J.W., Resveratrol protects against oxidized LDL-induced breakage of the blood-brain barrier by lessening disruption of tight junctions and apoptotic insults to mouse cerebrovascular endothelial cells (2010) J. Nutr., 140, pp. 2187-2192; \n\nLiu, L.B., Liu, X.B., Ma, J., Liu, Y.H., Li, Z.Q., Ma, T., Zhao, X.H., Xue, Y.X., Bradykinin increased the permeability of BTB via NOS/NO/ZONAB-mediating down-regulation of claudin-5 and occludin (2015) Biochem. Biophys. Res. Commun., 464, pp. 118-125; \n\nMa, T., Liu, L., Wang, P., Xue, Y., Evidence for involvement of ROCK signaling in bradykinin-induced increase in murine blood-tumor barrier permeability (2012) J. Neurooncol., 106, pp. 291-301; \n\nMorgan-Boyd, R., Stewart, J.M., Vavrek, R.J., Hassid, A., Effects of bradykinin and angiotensin II on intracellular Ca2+ dynamics in endothelial cells (1987) Am. J. Physiol., 253, pp. C588-C598; \n\nNakagawa, T., Hirakata, H., Sato, M., Nakamura, K., Hatano, Y., Nakamura, T., Fukuda, K., Ketamine suppresses platelet aggregation possibly by suppressed inositol triphosphate formation and subsequent suppression of cytosolic calcium increase (2002) Anesthesiology, 96, pp. 1147-1152; \n\nOgawa, K., Tanaka, S., Murray, P.A., Inhibitory effects of etomidate and ketamine on endothelium-dependent relaxation in canine pulmonary artery (2001) Anesthesiology, 94, pp. 668-677; \n\nStamatovic, S.M., Keep, R.F., Andjelkovic, A.V., Brain endothelial cell–cell junctions: how to open the blood–brain barrier (2008) Curr. Neuropharmacol., 6, pp. 179-192; \n\nSugibayashi, K., Onuki, Y., Takayama, K., Displacement of tight junction proteins from detergent- resistant membrane domains by treatment with sodium caprate (2009) Eur. J. Pharm. Sci., 36, pp. 246-253; \n\nSung, C.P., Arleth, A.J., Shikano, K., Berkowitz, B.A., Characterization and function of bradykinin receptors in vascular endothelial cells (1988) J. Pharmacol. Exp. Ther., 247, pp. 8-13; \n\nTilly, B.C., van Paridon, P.A., Verlaan, I., Wirtz, K.W., de Laat, S.W., Moolenaar, W.H., Inositol phosphate metabolism in bradykinin-stimulated human A431 carcinoma cells. Relationship to calcium signalling (1987) Biochem. J., 244, pp. 129-135; \n\nTsukamoto, T., Nigam, S.K., Tight junction proteins form large complexes and associate with the cytoskeleton in an ATP depletion model for reversible junction assembly (1997) J. Biol. Chem., 272, pp. 16133-16139; \n\nUnterberg, A., Baethmann, A., Lanksch, W., Prevention and treatment of secondary brain damage. Clinical aspects (1991) Chest, 100, pp. 200S-202S; \n\nWang, Y.B., Peng, C., Liu, Y.H., Low dose of bradykinin selectively increases intracellular calcium in glioma cells (2007) J. Neurol. Sci., 258, pp. 44-51; \n\nWeiss, N., Miller, F., Cazaubon, S., Couraud, P.O., The blood-brain barrier in brain homeostasis and neurological diseases (2009) Biochim. Biophys. Acta, 1788, pp. 842-857; \n\nWilhelm, I., Farkas, A.E., Nagyoszi, P., Váró, G., Bálint, Z., Végh, G.A., Couraud, P.O., Krizbai, I.A., Regulation of cerebral endothelial cell morphology by extracellular calcium (2007) Phys. Med. Biol., 52, pp. 6261-6274; \n\nWu, G.J., Wang, W., Lin, Y.L., Liu, S.H., Chen, R.M., Oxidative stress-induced apoptotic insults to rat osteoblasts are attenuated by nitric oxide pretreatment via GATA-5-involved regulation of Bcl-XL gene expression and protein translocation (2016) Arch. Toxicol., 90, pp. 905-916; \n\nYano, K., Higashida, H., Hattori, H., Nozawa, Y., Bradykinin-induced transient accumulation of inositol trisphosphate in neuron-like cell line NG108–15 cells (1985) FEBS Lett., 181, pp. 403-406; \n\nZhou, L., Yang, B., Wang, Y., Zhang, H.L., Chen, R.W., Wang, Y.B., Bradykinin regulates the expression of claudin-5 in brain microvascular endothelial cells via calcium-induced calcium release (2014) J. Neurosci. Res., 92, pp. 597-606", "hasCitationDuplums" : false, "userChangeableUntil" : "2017-03-07T08:44:31.000+0000", "publishDate" : "2016-12-07T08:44:31.000+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 7, "ownerInstituteCount" : 11, "directInstituteCount" : 0, "authorCount" : 6, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/26249348", "label" : "Chen J-T et al. 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