{ "labelLang" : "hun", "responseDate" : "2024-03-28 15:19", "content" : { "otype" : "JournalArticle", "mtid" : 26178279, "status" : "ADMIN_APPROVED", "published" : true, "comment" : "Export Date: 7 January 2020 \n CODEN: ZYYZE \n Correspondence Address: Sun, H.-S.; Department of Physiology, University of TorontoCanada; email: hss.sun@utoronto.ca", "unhandledTickets" : 0, "oldTimestamp" : "2016-11-23T14:01:19.000+0000", "deleted" : false, "oldId" : 16178279, "lastRefresh" : "2023-05-16T17:49:47.308+0000", "lastModified" : "2020-01-07T21:34:14.225+0000", "created" : "2016-11-23T13:56:19.000+0000", "creator" : { "otype" : "Author", "mtid" : 10015499, "link" : "/api/author/10015499", "label" : "Csanády László (Biokémia)", "familyName" : "Csanády", "givenName" : "László", "published" : true, "oldId" : 10015499, "snippet" : true }, "lastDuplumSearch" : "2023-05-14T20:36:17.932+0000", "adminApproved" : "2020-01-07T21:34:14.238+0000", "adminApprover" : { "otype" : "Admin", "mtid" : 10015544, "link" : "/api/admin/10015544", "label" : "Csajbók Edit (SE_KK_Admin5_CSE, admin)", "familyName" : "Csajbók", "givenName" : "Edit", "published" : true, "oldId" : 10015544, "snippet" : true }, "core" : false, "citation" : true, "publicationPending" : false, "type" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "subType" : { "otype" : "SubType", "mtid" : 1134514, "link" : "/api/subtype/1134514", "label" : "Összefoglaló cikk (Folyóiratcikk)", "name" : "Összefoglaló cikk", "nameEng" : "Survey paper", "docType" : { "otype" : "PublicationType", "mtid" : 24, "link" : "/api/publicationtype/24", "label" : "Folyóiratcikk", "code" : 24, "otypeName" : "JournalArticle", "listPosition" : 1, "published" : true, "oldId" : 24, "snippet" : true }, "listPosition" : 102, "published" : true, "oldId" : 1134514, "snippet" : true }, "category" : { "otype" : "Category", "mtid" : 1, "link" : "/api/category/1", "label" : "Tudományos", "published" : true, "oldId" : 1, "snippet" : true }, "languages" : [ { "otype" : "Language", "mtid" : 10002, "link" : "/api/language/10002", "label" : "Angol", "name" : "Angol", "nameEng" : "English", "published" : true, "oldId" : 2, "snippet" : true } ], "firstAuthor" : "Li, F-Y", "authorships" : [ { "otype" : "PersonAuthorship", "mtid" : 60849721, "link" : "/api/authorship/60849721", "label" : "Li, F-Y", "listPosition" : 1, "share" : 0.0, "first" : true, "last" : false, "familyName" : "Li", "givenName" : "F-Y", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 124691166, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 60849722, "link" : "/api/authorship/60849722", "label" : "Wong, R", "listPosition" : 2, "share" : 0.0, "first" : false, "last" : false, "familyName" : "Wong", "givenName" : "R", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 124691165, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 60849723, "link" : "/api/authorship/60849723", "label" : "Turlova, E", "listPosition" : 3, "share" : 0.0, "first" : false, "last" : false, "familyName" : "Turlova", "givenName" : "E", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 124691164, "snippet" : true }, { "otype" : "PersonAuthorship", "mtid" : 60849724, "link" : "/api/authorship/60849724", "label" : "Sun, H-S", "listPosition" : 4, "share" : 0.0, "first" : false, "last" : true, "familyName" : "Sun", "givenName" : "H-S", "authorTyped" : true, "editorTyped" : false, "otherTyped" : false, "type" : { "otype" : "AuthorshipType", "mtid" : 1, "link" : "/api/authorshiptype/1", "label" : "Szerző", "code" : 0, "published" : true, "oldId" : 0, "snippet" : true }, "published" : false, "oldId" : 124691163, "snippet" : true } ], "title" : "Pathological role of transient receptor potential melastatin member 2 channel in neurodegenerative diseases and Alzheimer disease", "identifiers" : [ { "otype" : "PublicationIdentifier", "mtid" : 11710772, "link" : "/api/publicationidentifier/11710772", "label" : "DOI: 10.3867/j.issn.1000-3002.2016.06.005", "source" : { "otype" : "PlainSource", "mtid" : 6, "link" : "/api/publicationsource/6", "label" : "DOI", "type" : { "otype" : "PublicationSourceType", "mtid" : 10001, "link" : "/api/publicationsourcetype/10001", "label" : "DOI", "mayHaveOa" : true, "published" : true, "snippet" : true }, "name" : "DOI", "nameEng" : "DOI", "linkPattern" : "https://doi.org/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 6, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "10.3867/j.issn.1000-3002.2016.06.005", "realUrl" : "https://doi.org/10.3867/j.issn.1000-3002.2016.06.005", "published" : false, "oldId" : 13637980, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 14751631, "link" : "/api/publicationidentifier/14751631", "label" : "Wos-CSCD (Chinese): 5744735", "source" : { "otype" : "PlainSource", "mtid" : 61, "link" : "/api/publicationsource/61", "label" : "Wos-CSCD (Chinese)", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Wos-CSCD (Chinese)", "nameEng" : "Wos-CSCD (Chinese)", "linkPattern" : "https://www.webofscience.com/wos/cscd/full-record/@@@", "publiclyVisible" : true, "published" : true, "oldId" : 61, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "5744735", "realUrl" : "https://www.webofscience.com/wos/cscd/full-record/5744735", "published" : false, "oldId" : 17378216, "snippet" : true }, { "otype" : "PublicationIdentifier", "mtid" : 11710771, "link" : "/api/publicationidentifier/11710771", "label" : "Scopus: 84986612652", "source" : { "otype" : "PlainSource", "mtid" : 3, "link" : "/api/publicationsource/3", "label" : "Scopus", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Scopus", "linkPattern" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@", "publiclyVisible" : true, "published" : true, "oldId" : 3, "snippet" : true }, "validState" : "IDENTICAL", "idValue" : "84986612652", "realUrl" : "http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84986612652", "published" : false, "oldId" : 13637979, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 10031624, "link" : "/api/journal/10031624", "label" : "CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY / ZHONG GUO YAO LI XUE YU DU LI XUE ZA ZHI 1000-3002", "pIssn" : "1000-3002", "reviewType" : "REVIEWED", "noIF" : true, "sciIndexed" : false, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 10031624, "snippet" : true }, "volume" : "30", "issue" : "6", "firstPage" : "656", "lastPage" : "666", "firstPageOrInternalIdForSort" : "656", "pageLength" : 11, "publishedYear" : 2016, "digital" : null, "printed" : null, "sourceYear" : 2016, "packet" : "552721", "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : null, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2023-05-16", "oaFree" : false, "citationCount" : 0, "citationCountUnpublished" : 0, "citationCountWoOther" : 0, "independentCitCountWoOther" : 0, "doiCitationCount" : 0, "wosCitationCount" : 0, "scopusCitationCount" : 0, "independentCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 0, "independentCitingPubCount" : 0, "unhandledCitingPubCount" : 0, "citedPubCount" : 3, "citedCount" : 3, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10955477, "link" : "/api/sjrrating/10955477", "label" : "sjr:Q4 (2016) Scopus - Pharmacology CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY / ZHONG GUO YAO LI XUE YU DU LI XUE ZA ZHI 1000-3002", "listPos" : 298, "rankValue" : 1.0, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 3004, "link" : "/api/classificationexternal/3004", "label" : "Scopus - Pharmacology", "published" : true, "oldId" : 3004, "snippet" : true }, "ranking" : "Q4", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q4", "referenceList" : "Simon, F., Varela, D., Cabello-Verrugio, C., Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans [J] (2013) Cell Signal, 25 (7), pp. 1614-1624; \n\nIrie, S., Furukawa, T., TRPM1 [J] (2014) Handb Exp Pharmacol, 222, pp. 387-402; \n\nHofmann, T., Schaefer, M., Schultz, G., Gudermann, T., Transient receptor potential channels as molecular substrates of receptor-mediated cation entry [J] (2000) J Mol Med (Berl), 78 (1), pp. 14-25; \n\nMinke, B., The history of the drosophila TRP channel: The birth of a new channel superfamily [J] (2010) J Neurogenet, 24 (4), pp. 216-233; \n\nNilius, B., Flockerzi, V., Mammalian transient receptor potential (TRP) cation channels. Preface [J] (2014) Handb Exp Pharmacol, 223, pp. V-VI; \n\nMontell, C., Rubin, G.M., Molecular characterization of the drosophila TRP locus: A putative integral membrane protein required for phototransduction [J] (1989) Neuron, 2 (4), pp. 1313-1323; \n\nHuang, C.L., The transient receptor potential super- family of ion channels [J] (2004) J Am Soc Nephrol, 15 (7), pp. 1690-1699; \n\nBouron, A., Kiselyov, K., Oberwinkler, J., Permeation, regulation and control of expression of TRP channels by trace metal ions [J] (2015) Pflugers Arch, 467 (6), pp. 1143-1164; \n\nGees, M., Colsoul, B., Nilius, B., The role of transient receptor potential cation channels in Ca2+ signaling [J] (2010) Cold Spring Harb Perspect Biol, 2 (10), p. a003962; \n\nClapham, D.E., Runnels, L.W., Strubing, C., The TRP ion channel family [J] (2001) Nat Rev Neurosci, 2 (6), pp. 387-396; \n\nBenemei, S., De Cesaris, F., Fusi, C., Rossi, E., Lupi, C., Geppetti, P., TRPAI and other TRP channels in mi- graine [J] (2013) J Headache Pain, 14, p. 71; \n\nPan, Z., Yang, H., Reinach, P.S., Transient receptor potential (TRP) gene superfamily encoding cation channels [J] (2011) Hum Genomics, 5 (2), pp. 108-116; \n\nHellmich, U.A., Gaudet, R., Structural biology of TRP channels [J] (2014) Handb Exp Pharmacol, 223, pp. 963-990; \n\nLi, M., Yu, Y., Yang, J., Structural biology of TRP channels [J] (2011) Adv Exp Med Biol, 704, pp. 1-23; \n\nMorelli, M.B., Amantini, C., Liberati, S., Santoni, M., Nabissi, M., TRP channels: New potential therapeutic approaches in CNS neuropathies [J] (2013) CNS Neurol Disord Drug Targets, 12 (2), pp. 274-293; \n\nZheng, J., Molecular mechanism of TRP channels [J] (2013) Compr Physiol, 3 (1), pp. 221-242; \n\nUchida, K., Dezaki, K., Damdindorj, B., Inada, H., Shiuchi, T., Mori, Y., Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice [J] (2011) Diabetes, 60 (1), pp. 119-126; \n\nOberwinkler, J., Philipp, S.E., TRPM3 [J] (2007) Handb Exp Pharmacol, 179, pp. 253-267; \n\nVriens, J., Owsianik, G., Hofmann, T., Philipp, S.E., Stab, J., Chen, X., TRPM3 is a nociceptor channel involved in the detection of noxious heat [J] (2011) Neuron, 70 (3), pp. 482-494; \n\nOberwinkler, J., Philipp, S.E., TRPM3 [J] (2014) Handb Exp Pharmacol, 222, pp. 427-459; \n\nQuallo, T., Vastani, N., Horridge, E., Gentry, C., Parra, A., Moss, S., TRPM8 is a neuronal osmosen- sor that regulates eye blinking in mice [J] (2015) Nat Commun, 6, p. 7150; \n\nYee, N.S., Roles of TRPM8 ion channels in cancer: Proliferation, survival, and invasion [J] (2015) Cancers, 7 (4), pp. 2134-2146. , Basel; \n\nCheng, H., Beck, A., Launay, P., Gross, S.A., Stokes, A.J., Kinet, J.P., TRPM4 controls insulin secretion in pancreatic beta cells [J] (2007) Cell Calcium, 41 (1), pp. 51-61; \n\nRoper, S.D., TRPs in taste and chemesthesis [J] (2014) Handb Exp Pharmacol, 223, pp. 827-871; \n\nVan Der Wijst, J., Bindels, R.J., Hoenderop, J.G., Mg2+ homeostasis: The balancing act of TRPM6 [J] (2014) Curr Opin Nephrol Hypertens, 23 (4), pp. 361-369; \n\nSun, H.S., Jackson, M.F., Martin, L.J., Jansen, K., Teves, L., Cui, H., Suppression of hippocam- pal TRPM7 protein prevents delayed neuronal death in brain ischemia [J] (2009) Nat Neurosci, 12 (10), pp. 1300-1307; \n\nChen, W., Xu, B., Xiao, A., Liu, L., Fang, X., Liu, R., TRPM7 inhibitor carvacrol protects brain from neonatal hypoxic-ischemic injury [J] (2015) Mol Brain, 8, p. 11; \n\nTurlova, E., Bae, C.Y., Deurloo, M., Chen, W., Barszczyk, A., Horgen, F.D., TRPM7 regulates axonal outgrowth and maturation of primary hippocampal neurons [J] (2016) Mol Neurobiol, 53 (1), pp. 595-610; \n\nXie, Y.F., Macdonald, J.F., Jackson, M.F., TRPM2, Calcium and neurodegenerative diseases [J] (2010) Int J Physiol Pathophysiol Pharmacol, 2 (2), pp. 95-103; \n\nMaqbool, M., Mobashir, M., Hoda, N., Pivotal role of glycogen synthase kinase-3: A therapeutic target for Alzheimer's disease [J] (2016) Eur J Med Chem, 107, pp. 63-81; \n\nSumoza-Toledo, A., Penner, R., TRPM2: A multifunctional ion channel for calcium signalling [J] (2011) J Physiol, 589, pp. 1515-1525; \n\nBelrose, J.C., Xie, Y.F., Gierszewski, L.J., MacDonald, J.F., Jackson, M.F., Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons [J] (2012) Mol Brain, 5, p. 11; \n\nRempe, D.A., Takano, T., Nedergaard, M., TR(l)Pping towards treatment for ischemia [J] (2009) Nat Neurosci, 12 (10), pp. 1215-1216; \n\nToth, B., Lordanov, I., Csanady, L., Putative chanzyme activity of TRPM2 cation channel is unrelated to pore gating [J] (2014) Proc Natl Acad Sci USA, 111 (47), pp. 16949-16954; \n\nUemura, T., Kudoh, J., Noda, S., Kanba, S., Shimizu, N., Characterization of human and mouse TRPM2 genes: Identification of a novel N-Terminal truncated protein specifically expressed in human striatum [J] (2005) Biochem Biophys Res Commun, 328 (4), pp. 1232-1243; \n\nGelderblom, M., Melzer, N., Schattling, B., Gob, E., Hicking, G., Arunachalam, P., Transient receptor potential melastatin subfamily member 2 cation channel regulates detrimental immune cell invasion in ischemic stroke [J] (2014) Stroke, 45 (11), pp. 3395-3402; \n\nTong, Q., Zhang, W., Conrad, K., Mostoller, K., Cheung, J.Y., Peterson, B.Z., Regulation of the transient receptor potential channel TRPM2 by the Ca2+ sensor calmodulin [J] (2006) J Biol Chem, 281 (14), pp. 9076-9085; \n\nSano, Y., Inamura, K., Miyake, A., Mochizuki, S., Yokoi, H., Matsushime, H., Immunocyte Ca2+ influx system mediated by LTRPC2[J] (2001) Science, 293 (5533), pp. 1327-1330; \n\nMcHugh, D., Flemming, R., Xu, S.Z., Perraud, A.L., Beech, D.J., Critical intracellular Ca2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation [J] (2003) J Biol Chem, 278 (13), pp. 11002-11006; \n\nKheradpezhouh, E., Ma, L., Morphett, A., Barritt, G.J., Rychkov, G.Y., TRPM2 channels mediate acetaminophen-induced liver damage [J] (2014) Proc Natl Acad Sci USA, 111 (8), pp. 3176-3181; \n\nKolisek, M., Beck, A., Fleig, A., Penner, R., Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels [J] (2005) Mol Cell, 18 (1), pp. 61-69; \n\nYamamoto, S., Shimizu, S., Mori, Y., Involvement of TRPM2 channel in amplification of reactive oxygen species-induced signaling and chronic inflammation [J] (2009) Nihon Yakurigaku Zasshi, 134 (3), pp. 122-126; \n\nYamamoto, S., Wajima, T., Hara, Y., Nishida, M., Mori, Y., Transient receptor potential channels in Alzheimer's disease [J] (2007) Biochim Biophys Acta, 1772 (8), pp. 958-967; \n\nOstapchenko, V.G., Chen, M., Guzman, M.S., Xie, Y.F., Lavine, N., Fan, J., The transient receptor potential melastatin 2 (TRPM2) channel contributes to (3-Amyloid oligomer-related neurotoxicity and [57] memory impairment [J] (2015) J Neurosci, 35 (45), pp. 15157-15169; \n\nWang, J., Jackson, M.F., Xie, Y.F., Glia and TRPM2 channels in plasticity of central nervous system and Alzheimer' s diseases [J] (2016) Neural Plast, p. 1680905; \n\nMattson, M.P., Cheng, B., Davis, D., Bryant, K., Lieberburg, I., Rydel, R.E., Beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity [J] (1992) J Neurosci, 12 (2), pp. 376-389; \n\nO'Brien, R.J., Wong, P.C., Amyloid precursor protein processing and Alzheimer's disease [J] (2011) Annu Rev Neurosci, 34 (1), pp. 185-204; \n\nNunan, J., Small, D.H., Regulation of APP cleavage by alpha-, beta-And gamma-secretases [J] (2000) FEBS Lett, 483 (1), pp. 6-10; \n\nIrvine, G.B., El-Agnaf, O.M., Shankar, G.M., Walsh, D.M., Protein aggregation in the brain: The molecular basis for Alzheimer's and Parkinson's diseases [J] (2008) Mol Med, 14 (7-8), pp. 451-464; \n\nLemere, C.A., Masliah, E., Can Alzheimer disease be prevented by amyloid-beta immunotherapy? [J] (2010) Nat Rev Neurol, 6 (2), pp. 108-119; \n\nMosconi, L., Berti, V., Glodzik, L., Pupi, A., De Santi, S., De Leon, M.J., Pre-clinical detection of Alzheimer's disease using FDG-PET, with or without amyloid imaging [J] (2010) J Alzheimers Dis, 20 (3), pp. 843-854; \n\nUttara, B., Singh, A.V., Zamboni, P., Mahajan, R.T., Oxidative stress and neurodegenerative diseases: A review of upstream and downstream antioxidant therapeutic options [J] (2009) Curr Neuropharma-col, 7 (1), pp. 65-74; \n\nGebicki, J.M., Oxidative stress, free radicals and protein peroxides [J] (2016) Arch Biochem Biophys, 595, pp. 33-39; \n\nBuelow, B., Song, Y., Scharenberg, A.M., The poly- (ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes [J] (2008) J Biol Chem, 283 (36), pp. 24571-24583; \n\nStarkus, J., Beck, A., Fleig, A., Penner, R., Regulation of TRPM2 by extra-And intracellular calcium [J] (2007) J Gen Physiol, 130 (4), pp. 427-440; \n\nCsanady, L., Torocsik, B., Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate [J] (2009) J Gen Physiol, 133 (2), pp. 189-203; \n\nLange, I., Penner, R., Fleig, A., Beck, A., Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils [J] (2008) Cell Calcium, 44 (6), pp. 604-615; \n\nZhang, Y., Qin, W., Zhang, L., Wu, X., Du, N., Hu, Y., MicroRNA-26a prevents endothelial cell apoptosis by directly targeting TRPC6 in the setting of atherosclerosis [J] (2015) Sci Rep, 5, p. 9401; \n\nTimothy, S.K., Teng, S., Stolier, A.J., Bolton, J.S., Fuhrman, G.M., Postmastectomy radiation in patients with four or more positive nodes [J] (2002) Am Surg, 68 (6), pp. 539-544; \n\nMattson, M.P., Duan, W., Apoptotic biochemical cascades in synaptic compartments: Roles in adaptive plasticity and neurodegenerative disorders [J] (1999) J Neurosci Res, 58 (1), pp. 152-166; \n\nKraft, R., Grimm, C., Grosse, K., Hoffmann, A., Sauerbruch, S., Kettenmann, H., Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia [J] (2004) Am J Physiol Cell Physiol, 286 (1), pp. C129-C137; \n\nHara, Y., Wakamori, M., Ishii, M., Maeno, E., Nishida, M., Yoshida, T., LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death [J] (2002) Mol Cell, 9 (1), pp. 163-173; \n\nTakahashi, N., Kozai, D., Kobayashi, R., Ebert, M., Mori, Y., Roles of TRPM2 in oxidative stress [J] (2011) Cell Calcium, 50 (3), pp. 279-287. , (SI); \n\nKnowles, H., Li, Y., Perraud, A.L., The TRPM2 ion channel, an oxidative stress and metabolic sensor regulating innate immunity and inflammation [J] (2013) Immunol Res, 55 (1-3), pp. 241-248; \n\nMiyake, T., Shirakawa, H., Kusano, A., Sakimoto, S., Konno, M., Nakagawa, T., TRPM2 contributes to LPS/IFNy-induced production of nitric oxide via the p38/JNK pathway in microglia [J] (2014) Biochem Biophys Res Commun, 444 (2), pp. 212-217; \n\nZhong, Z., Zhai, Y., Liang, S., Mori, Y., Han, R., Sutterwala, F.S., TRPM2 links oxidative stress to NLRP3 inflammasome activation [J] (2013) Nat Commun, 4, p. 1611; \n\nHaraguchi, K., Kawamoto, A., Isami, K., Maeda, S., Kusano, A., Asakura, K., TRPM2 contributes to inflammatory and neuropathic pain through the aggravation of pronociceptive inflammatory responses in mice [J] (2012) J Neurosci, 32 (11), pp. 3931-3941; \n\nIsami, K., Haraguchi, K., So, K., Asakura, K., Shirakawa, H., Mori, Y., Involvement of TRPM2 in peripheral nerve injury-induced infiltration of peripheral immune cells into the spinal cord in mouse neuropathic pain model [J] (2013) Plos One, 8 (7), p. e66410; \n\nSo, K., Haraguchi, K., Asakura, K., Isami, K., Sakimoto, S., Shirakawa, H., Involvement of TRPM2 in a wide range of inflammatory and neuropathic pain mouse models [J] (2015) J Pharmacol Sci, 127 (3), pp. 237-243; \n\nFonfria, E., Marshall, I.C., Boyfield, I., Skaper, S.D., Hughes, J.P., Owen, D.E., Amyloid beta-peptide (1-42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures [J] (2005) J Neurochem, 95 (3), pp. 715-723; \n\nHill, K., McNulty, S., Randall, A.D., Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole [J] (2004) Naunyn Schmiedebergs Arch Pharmacol, 370 (4), pp. 227-237; \n\nUllrich, N.D., Voets, T., Prenen, J., Vennekens, R., Talavera, K., Droogmans, G., Comparison of functional properties of the Ca2+-Activated cation channels TRPM4 and TRPM5 from mice [J] (2005) Cell Calcium, 37 (3), pp. 267-278; \n\nKraft, R., Harteneck, C., The mammalian melastatin-related transient receptor potential cation channels: An overview [J] (2005) Pflugers Arch, 451 (1), pp. 204-211; \n\nInoue, R., Okada, T., Onoue, H., Hara, Y., Shimizu, S., Naitoh, S., The transient receptor potential protein homologue TRP6 is the essential component of vascular alphal-Adrenoceptor-Activated Ca2+-permeable cation channel [J] (2001) Circ Res, 88 (3), pp. 325-332; \n\nEisfeld, J., Luckhoff, A., TRPM2 [M] (2007) Transient Receptor Potential (TRP) Channels, pp. 237-252. , Rosenthal W, ed. Springer Berlin Heidelberg; \n\nMaruyama, T., Kanaji, T., Nakade, S., Kanno, T., Mikoshiba, K., 2APB, 2-Aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins (1, 4, 5)P3-induced Ca2+ release[J] (1997) J Biochem, 122 (3), pp. 498-505; \n\nTogashi, K., Inada, H., Tominaga, M., Inhibition of the transient receptor potential cation channel TRPM2 by 2-Aminoethoxydiphenyl borate (2-APB) [J] (2008) Br J Pharmacol, 153 (6), pp. 1324-1330; \n\nHalaszovich, C.R., Zitt, C., Jungling, E., Luckhoff, A., Inhibition of TRP3 channels by lanthanides. Block from the cytosolic side of the plasma membrane [J] (2000) J Biol Chem, 275 (48), pp. 37423-37428; \n\nTousova, K., Vyklicky, L., Susankova, K., Benedikt, J., Vlachova, V., Gadolinium activates and sensitizes the vanilloid receptor TRPV1 through the external protonation sites [J] (2005) Mol Cell Neurosci, 30 (2), pp. 207-217; \n\nZeng, B., Chen, G.L., Xu, S.Z., Divalent copper is a potent extracellular blocker for TRPM2 channel [J] (2012) Biochem Biophys Res Commun, 424 (2), pp. 279-284; \n\nShimizu, S., Yonezawa, R., Hagiwara, T., Yoshida, T., Takahashi, N., Hamano, S., Inhibitory effects of AG490 on H202-induced TRPM2-mediated Ca2+ entry [J] (2014) Eur J Pharmacol, 742, pp. 22-30; \n\nNaziroglu, M., Luckhoff, A., A calcium influx pathway regulated separately by oxidative stress and ADP- ribose in TRPM2 channels: Single channel events [J] (2008) Neurochem Res, 33 (7), pp. 1256-1262; \n\nRosenbaum, T., Activators of TRPM2: Getting it right [J] (2015) J Gen Physiol, 145 (6), pp. 485-487; \n\nToth, B., Lordanov, I., Csanady, L., Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP- ribose-2'-phosphate [J] (2015) J Gen Physiol, 145 (5), pp. 419-430", "hasCitationDuplums" : false, "userChangeableUntil" : "2016-11-23T14:01:19.000+0000", "publishDate" : "2016-11-23T14:00:59.000+0000", "directInstitutesForSort" : "", "ownerAuthorCount" : 4, "ownerInstituteCount" : 19, "directInstituteCount" : 0, "authorCount" : 4, "contributorCount" : 0, "hasQualityFactor" : false, "link" : "/api/publication/26178279", "label" : "Li F-Y et al. Pathological role of transient receptor potential melastatin member 2 channel in neurodegenerative diseases and Alzheimer disease. (2016) CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY / ZHONG GUO YAO LI XUE YU DU LI XUE ZA ZHI 1000-3002 30 6 656-666", "template" : "